INT39999

Context Info Confidence 0.59 First Reported 1981 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 7 Total Number 8 Disease Relevance 3.27 Pain Relevance 0.69

hydrolase activity, acting on glycosyl bonds (Gla) extracellular region (Gla) Golgi apparatus (Gla) lysosome (Gla) cytoplasm (Gla)

Anatomy Link Frequency AGS 2 Gla (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 115 89.44 Substantia nigra 8 84.32 Ventral tegmentum 8 82.64 Serotonin 5 75.00 fluoxetine 1 74.88 midbrain 15 73.76 unmyelinated 2 72.16 Pain 3 65.04 monoamine 4 58.12 Inflammation 11 16.48

Disease Link Frequency Relevance Heat Alagille Syndrome 30 100.00 Stress 16 99.20 Targeted Disruption 12 94.68 Disease 12 87.20 Stomach Cancer 22 84.40 Syndrome 2 83.28 Anxiety Disorder 3 83.16 Epilepsy 2 75.00 Hypertrophy 3 64.64 Brain Tumor 1 57.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Results indicate that although reduced stress reactivity promotes exploration, this does not translate into an up-regulation of GLA, suggesting that the relationship between GLA and exploration is not mediated by stress reactivity.

Gene_expression (exploration) of GLA associated with stress

1) Confidence 0.59 Published 2007 Journal Behav. Neurosci. Section Abstract Doc Link 17907827 Disease Relevance 0.65 Pain Relevance 0

Moreover, the thermolabile isoenzyme A of alpha-D-galactosidase was almost completely absent.

Neg (absent) Gene_expression (absent) of alpha-D-galactosidase

2) Confidence 0.58 Published 1981 Journal Muscle Nerve Section Abstract Doc Link 6793867 Disease Relevance 0.24 Pain Relevance 0.13

However, CDP-treated mice did not exhibit facilitated acquisition of any of the learning tasks and expressed GLA comparable to controls.

Gene_expression (expressed) of GLA

3) Confidence 0.53 Published 2007 Journal Behav. Neurosci. Section Abstract Doc Link 17907827 Disease Relevance 0.67 Pain Relevance 0

These results suggest, first of all, that the inhibition of AGS produced by 6-MeO-THBC is a consequence of its combined MAO-A and 5-HT uptake inhibition properties.

Gene_expression (produced) of AGS in AGS associated with alagille syndrome

4) Confidence 0.48 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 4080761 Disease Relevance 0.91 Pain Relevance 0.17

Selected phage GLA.

Gene_expression (Selected) of GLA

5) Confidence 0.26 Published 2010 Journal Pharm Res Section Body Doc Link PMC2837178 Disease Relevance 0 Pain Relevance 0

Fig. 4Incubation of selected phage GLA, GYR, GTW and control phage YLR with hCMEC/D3 and HUVEC cells, recovery expressed as a percentage of the input.

Gene_expression (selected) of GLA

6) Confidence 0.26 Published 2010 Journal Pharm Res Section Body Doc Link PMC2837178 Disease Relevance 0 Pain Relevance 0

BSR-transfected AGS–GFP cells (Figure 6B), thus suggesting the existence of an NF-?

Gene_expression (transfected) of AGS in AGS associated with alagille syndrome

7) Confidence 0.05 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.48 Pain Relevance 0

In a previous report we first detected DAT-Cre mediated beta galactosidase expression in a conditional Rosa26LacZ reporter mice at embryonic day 17 [15], suggesting excision of Pten exon5 at around this developmental point.

Gene_expression (expression) of galactosidase

8) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.33 Pain Relevance 0.39

General Comments

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