INT40006

Context Info Confidence 0.53 First Reported 1985 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 4.59 Pain Relevance 0.65

nuclear envelope (DNASE1) extracellular region (DNASE1) nucleus (DNASE1)

Anatomy Link Frequency liver 2 DNASE1 (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 3 96.16 Paracetamol 166 95.84 qutenza 3 50.00 alcohol 2 37.64 Analgesic 1 12.52 anesthesia 12 12.40 Pain 4 8.76 cINOD 3 7.68 Inflammation 15 6.28 imagery 3 5.00

Disease Link Frequency Relevance Heat Coronary Artery Disease 8 99.92 Pancreatic Cancer 5 97.40 Death 77 96.88 Apoptosis 199 96.44 Pancreatitis 4 96.16 Disease 7 93.96 Stress 14 93.56 Rupture 1 91.84 Pressure And Volume Under Development 5 90.88 Toxicity 31 90.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The expression of inhibitor of caspase activated DNase (ICAD) was reduced with the lapse of time.

Positive_regulation (activated) of DNase

1) Confidence 0.53 Published 2005 Journal Zhonghua Zhong Liu Za Zhi Section Body Doc Link 16188123 Disease Relevance 0.16 Pain Relevance 0

Increased DNase and RNase values were found not only in a notable proportion of pancreatic cancer, but also in chronic pancreatitis and extra-pancreatic diseases.

Positive_regulation (Increased) of DNase associated with pancreatitis, pancreatic cancer and chronic pancreatitis

2) Confidence 0.06 Published 1985 Journal Tumori Section Abstract Doc Link 4082285 Disease Relevance 0.90 Pain Relevance 0.26

Nagata also showed that, the DNA ladder nuclease (now known as caspase activated DNase or CAD) pre-exists in living cells as an inactive complex with an inhibitor subunit.

Positive_regulation (activated) of DNase associated with coronary artery disease

3) Confidence 0.06 Published 2006 Journal J Carcinog Section Body Doc Link PMC1705806 Disease Relevance 1.31 Pain Relevance 0

The obtained DNase activation seems to be associated with the programmed destruction of the genome and cell death.

Positive_regulation (activation) of DNase associated with death

4) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.10 Pain Relevance 0

Some of them, including specific caspase3-activated DNase (CAD), are active upon release of the specific inhibitor ICAD [27,28].

Positive_regulation (caspase3-activated) of DNase associated with coronary artery disease

5) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.32 Pain Relevance 0

The activity of liver alkaline DNase increased and that of acid DNase decreased after in vivo treatment with either SNP or peroxynitrite (Table 2).

Positive_regulation (increased) of DNase in liver

6) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.25 Pain Relevance 0

Alkaline DNase activation seems to be associated with the programmed destruction of the genome, leading to the fragmentation of damaged DNA sites.

Positive_regulation (activation) of DNase

7) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Abstract Doc Link PMC516785 Disease Relevance 0.12 Pain Relevance 0

The activity of liver alkaline DNase increased and that of acid DNase decreased after in vivo treatment with either SNP or peroxynitrite.

Positive_regulation (increased) of DNase in liver

8) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Abstract Doc Link PMC516785 Disease Relevance 0.24 Pain Relevance 0

In vivo administrated SNP and peroxynitrite increase the activity of alkaline DNase.

Positive_regulation (increase) of DNase

9) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.09 Pain Relevance 0

These factors also activate caspases and, subsequently, caspase-activated DNase [15].

Positive_regulation (activated) of DNase

10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 1.11 Pain Relevance 0.39

General Comments

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