INT40006

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Context Info
Confidence 0.53
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.59
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (DNASE1) extracellular region (DNASE1) nucleus (DNASE1)
Anatomy Link Frequency
liver 2
DNASE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 96.16 Very High Very High Very High
Paracetamol 166 95.84 Very High Very High Very High
qutenza 3 50.00 Quite Low
alcohol 2 37.64 Quite Low
Analgesic 1 12.52 Low Low
anesthesia 12 12.40 Low Low
Pain 4 8.76 Low Low
cINOD 3 7.68 Low Low
Inflammation 15 6.28 Low Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 8 99.92 Very High Very High Very High
Pancreatic Cancer 5 97.40 Very High Very High Very High
Death 77 96.88 Very High Very High Very High
Apoptosis 199 96.44 Very High Very High Very High
Pancreatitis 4 96.16 Very High Very High Very High
Disease 7 93.96 High High
Stress 14 93.56 High High
Rupture 1 91.84 High High
Pressure And Volume Under Development 5 90.88 High High
Toxicity 31 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of inhibitor of caspase activated DNase (ICAD) was reduced with the lapse of time.
Positive_regulation (activated) of DNase
1) Confidence 0.53 Published 2005 Journal Zhonghua Zhong Liu Za Zhi Section Body Doc Link 16188123 Disease Relevance 0.16 Pain Relevance 0
Increased DNase and RNase values were found not only in a notable proportion of pancreatic cancer, but also in chronic pancreatitis and extra-pancreatic diseases.
Positive_regulation (Increased) of DNase associated with pancreatitis, pancreatic cancer and chronic pancreatitis
2) Confidence 0.06 Published 1985 Journal Tumori Section Abstract Doc Link 4082285 Disease Relevance 0.90 Pain Relevance 0.26
Nagata also showed that, the DNA ladder nuclease (now known as caspase activated DNase or CAD) pre-exists in living cells as an inactive complex with an inhibitor subunit.
Positive_regulation (activated) of DNase associated with coronary artery disease
3) Confidence 0.06 Published 2006 Journal J Carcinog Section Body Doc Link PMC1705806 Disease Relevance 1.31 Pain Relevance 0
The obtained DNase activation seems to be associated with the programmed destruction of the genome and cell death.
Positive_regulation (activation) of DNase associated with death
4) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.10 Pain Relevance 0
Some of them, including specific caspase3-activated DNase (CAD), are active upon release of the specific inhibitor ICAD [27,28].
Positive_regulation (caspase3-activated) of DNase associated with coronary artery disease
5) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.32 Pain Relevance 0
The activity of liver alkaline DNase increased and that of acid DNase decreased after in vivo treatment with either SNP or peroxynitrite (Table 2).
Positive_regulation (increased) of DNase in liver
6) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.25 Pain Relevance 0
Alkaline DNase activation seems to be associated with the programmed destruction of the genome, leading to the fragmentation of damaged DNA sites.
Positive_regulation (activation) of DNase
7) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Abstract Doc Link PMC516785 Disease Relevance 0.12 Pain Relevance 0
The activity of liver alkaline DNase increased and that of acid DNase decreased after in vivo treatment with either SNP or peroxynitrite.
Positive_regulation (increased) of DNase in liver
8) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Abstract Doc Link PMC516785 Disease Relevance 0.24 Pain Relevance 0
In vivo administrated SNP and peroxynitrite increase the activity of alkaline DNase.
Positive_regulation (increase) of DNase
9) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.09 Pain Relevance 0
These factors also activate caspases and, subsequently, caspase-activated DNase [15].
Positive_regulation (activated) of DNase
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 1.11 Pain Relevance 0.39

General Comments

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