INT40007

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1985
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 4
Total Number 7
Disease Relevance 2.98
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (DNASE1) extracellular region (DNASE1) nucleus (DNASE1)
Anatomy Link Frequency
plasma 2
liver 1
blast cell 1
DNASE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 96.84 Very High Very High Very High
halothane 1 96.72 Very High Very High Very High
anesthesia 8 90.24 High High
Angina 1 53.48 Quite High
Inflammation 11 12.32 Low Low
iatrogenic 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Empyema 43 99.48 Very High Very High Very High
Apoptosis 75 99.36 Very High Very High Very High
Pancreatic Cancer 5 98.08 Very High Very High Very High
Suppuration 10 97.02 Very High Very High Very High
Pancreatitis 4 96.84 Very High Very High Very High
Stress 6 96.68 Very High Very High Very High
Liver Cancer 3 94.08 High High
Disease 9 93.56 High High
Adhesions 1 80.92 Quite High
Dyspnea 2 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently there has been an interest in intrapleural DNase as a possible candidate in combination with thrombolytic therapy to enhance pus drainage.44 In an animal model, the combination of recombinant tissue plasminogen activator (alteplase) and recombinant human deoxyribonnuclease (rhDNase) has been shown to be more effective in treating empyema than either agent used alone.45 Successful treatment of human empyema with intrapleural rhDNase given after intrapleural fibrinolytic therapy has been described in at least one case report.46
Regulation (effective) of DNase associated with suppuration and empyema
1) Confidence 0.44 Published 2010 Journal Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine Section Body Doc Link PMC2998927 Disease Relevance 0.98 Pain Relevance 0.05
The released DNase activities do not originate from dead cells and are not influenced by blast cell formation.
Neg (not) Regulation (influenced) of DNase in blast cell
2) Confidence 0.27 Published 1995 Journal Z. Naturforsch., C, J. Biosci. Section Abstract Doc Link 7546035 Disease Relevance 0 Pain Relevance 0.21
We inoculated human plasma with Adenovirus Type 17 and examined the effects of filtration, DNAse treatment and RNAse treatment on Adenovirus Type 17 DNA and on human ?
Spec (examined) Regulation (effects) of DNAse in plasma
3) Confidence 0.04 Published 2007 Journal Virol J Section Body Doc Link PMC1950496 Disease Relevance 0 Pain Relevance 0
On the basis of the pharmacological data supporting the critical role of NO and peroxynitrite in apoptosis, current research studies have evaluated the activity of alkaline and acid DNase during the administration of SNP or of peroxynitrite, as well as the changes in numerous susceptible parameters of nitrosative stress, including SH group oxidation, carbonyl group formation, lipid peroxidation and DNA modification.
Regulation (evaluated) of DNase associated with stress and apoptosis
4) Confidence 0.03 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.56 Pain Relevance 0
Increased DNase and RNase values were found not only in a notable proportion of pancreatic cancer, but also in chronic pancreatitis and extra-pancreatic diseases.
Regulation (values) of DNase associated with pancreatitis, pancreatic cancer and chronic pancreatitis
5) Confidence 0.03 Published 1985 Journal Tumori Section Abstract Doc Link 4082285 Disease Relevance 0.90 Pain Relevance 0.26
The effect on liver tissue alkaline and acid DNase activity together with the markers of tissue and plasma oxidative and nitrosative stress (lipid peroxidation, SH group content, carbonyl groups and nitrotyrosine formation) was investigated in plasma and liver tissue.
Spec (investigated) Regulation (effect) of DNase in plasma associated with stress
6) Confidence 0.02 Published 2004 Journal Comp Hepatol Section Abstract Doc Link PMC516785 Disease Relevance 0.27 Pain Relevance 0
The effect on liver tissue alkaline and acid DNase activity together with the markers of tissue and plasma oxidative and nitrosative stress (lipid peroxidation, SH group content, carbonyl groups and nitrotyrosine formation) was investigated in plasma and liver tissue.
Spec (investigated) Regulation (effect) of DNase in liver associated with stress
7) Confidence 0.01 Published 2004 Journal Comp Hepatol Section Abstract Doc Link PMC516785 Disease Relevance 0.27 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox