INT40023

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Context Info
Confidence 0.52
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.37
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Tcstv1) cellular_component (Tcstv1) biological_process (Tcstv1)
Anatomy Link Frequency
sensory neurons 1
myofibroblast cells 1
Tcstv1 (Mus musculus)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 12 98.68 Very High Very High Very High
diabetic neuropathy 7 88.16 High High
palliative 1 84.68 Quite High
Kinase C 1 81.88 Quite High
c fibre 1 66.84 Quite High
Spinal cord 14 63.64 Quite High
Sciatic nerve 12 59.88 Quite High
Peripheral nervous system 6 53.04 Quite High
Inflammation 5 47.56 Quite Low
qutenza 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Carpal Tunnel Syndrome 12 98.68 Very High Very High Very High
Neuropathic Pain 24 88.48 High High
Diabetic Neuropathy 7 88.16 High High
Prediabetic State 6 86.32 High High
Metabolic Syndrome 9 84.16 Quite High
Stress 13 81.00 Quite High
Cancer 1 78.12 Quite High
Malignant Neoplastic Disease 1 77.76 Quite High
Sarcoma 2 76.56 Quite High
Diabetes Mellitus 17 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regarding histological grading, significant difference between Stage I + II and III + IV could be detected in the survival rates (p less than 0.05).
Gene_expression (detected) of Stage I + II and III + IV
1) Confidence 0.52 Published 1985 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 4088186 Disease Relevance 0.31 Pain Relevance 0.08
Furthermore, histamine caused a 2.5-fold increase in the production of 12-hydroxyeicosatetraenoic acid, a metabolite of LO, in cultured sensory neurons.
Gene_expression (production) of LO in sensory neurons
2) Confidence 0.12 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17329430 Disease Relevance 0.20 Pain Relevance 0.07
B and activator protein-1 as well as cytosolic Ca++ accumulation (reviewed in [55]), that is, via upregulation of three factors essentially required for LO gene expression and activity [25, 26].
Gene_expression (expression) of LO gene
3) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2852597 Disease Relevance 0.95 Pain Relevance 0.23
The goal of the current study was to determine LO activity and the effects of TGF beta 1 on LO expression in the cells from patients with CTS.
Gene_expression (expression) of LO associated with carpal tunnel syndrome
4) Confidence 0.01 Published 2000 Journal J. Occup. Environ. Med. Section Abstract Doc Link 10874650 Disease Relevance 0.53 Pain Relevance 0.53
Lysyl oxidase (LO) is produced by myofibroblast cells in some tissues and can be influenced by transforming growth factor beta 1 (TGF beta 1).
Gene_expression (produced) of LO in myofibroblast cells
5) Confidence 0.01 Published 2000 Journal J. Occup. Environ. Med. Section Abstract Doc Link 10874650 Disease Relevance 0.38 Pain Relevance 0.38

General Comments

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