INT4003

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Context Info
Confidence 0.46
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 20.38
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHG3)
Anatomy Link Frequency
blood 4
spleen 4
bile duct 2
accessory cells 2
B lymphocytes 2
IGHG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 10 100.00 Very High Very High Very High
cytokine 80 99.98 Very High Very High Very High
fibrosis 184 99.70 Very High Very High Very High
Enkephalin 2 98.60 Very High Very High Very High
Bile 75 97.56 Very High Very High Very High
aspirin 44 96.72 Very High Very High Very High
opioid receptor 2 91.76 High High
Pain 53 88.20 High High
agonist 4 87.28 High High
Infliximab 39 86.40 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 34 99.92 Very High Very High Very High
Sclerosing Cholangitis 68 99.88 Very High Very High Very High
Sprains And Strains 41 99.84 Very High Very High Very High
Serum Sickness 13 99.80 Very High Very High Very High
Eosinophilia 10 99.80 Very High Very High Very High
Enteritis 6 99.74 Very High Very High Very High
Pancreatitis 685 99.70 Very High Very High Very High
Fibrosis 153 99.70 Very High Very High Very High
Thrombocytopenia 1 99.68 Very High Very High Very High
Fatty Liver 24 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 2001, many reports have shown that serum IgG4 levels specifically elevate in patients with autoimmune pancreatitis (AIP), suggesting its clinical usefulness in discrimination between AIP and pancreatic cancer.
Positive_regulation (elevate) of Gene_expression (levels) of IgG4 associated with pancreatic cancer and pancreatitis
1) Confidence 0.46 Published 2010 Journal Rinsho Byori Section Abstract Doc Link 20496768 Disease Relevance 0.70 Pain Relevance 0.08
In Western blots, sera from 92% of EE/PE patients demonstrated IgG and IgE antibodies to a component of ES antigen with a molecular weight of approximately 68 kD (Ac68), as did all sera from cases infected with human hookworms.
Positive_regulation (demonstrated) of Gene_expression (demonstrated) of IgG associated with enteritis and eosinophilia
2) Confidence 0.45 Published 1994 Journal Am. J. Trop. Med. Hyg. Section Abstract Doc Link 8304575 Disease Relevance 1.74 Pain Relevance 0.05
Classically, passive transfer of hyperimmune IgG to patients infected with P. falciparum has shown that antibodies play a crucial role in controlling blood stage parasitaemia [42,43].
Positive_regulation (transfer) of Gene_expression (transfer) of IgG in blood
3) Confidence 0.43 Published 2005 Journal Malar J Section Body Doc Link PMC548665 Disease Relevance 0.30 Pain Relevance 0
(i) It was dependent on serum IgG1 and IgG3 isotypes, which mediate antibody interactions with accessory cells via Fc?
Positive_regulation (on) of Gene_expression (isotypes) of IgG3 in accessory cells
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.14 Pain Relevance 0.04
25 (IgG subclasses) were added in duplicate and incubated at room temperature for 2 h.
Positive_regulation (incubated) of Gene_expression (subclasses) of IgG
5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764341 Disease Relevance 0.07 Pain Relevance 0
The transplacental transfer of morphine and morphine-3-glucuronide (M3G) was studied in five cases of suspected Rh-isoimmunization.
Positive_regulation (transfer) of Gene_expression (transfer) of M3G associated with morphine
6) Confidence 0.33 Published 1990 Journal J Perinat Med Section Abstract Doc Link 2262875 Disease Relevance 0 Pain Relevance 0.55
Although class switching appears to be influenced by intensity of antigen stimulation and the age of the individual, young children appear to be deficient in promoting IgG3 production (17).
Positive_regulation (promoting) of Gene_expression (production) of IgG3
7) Confidence 0.32 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.47 Pain Relevance 0
The protection afforded by passive transfer of IgG from African adults into infected Thai children identified the cooperation of IgG with blood monocytes as a main defense mechanism in human beings in an antibody dependent, cellular inhibitory fashion (ADCI).
Positive_regulation (transfer) of Gene_expression (transfer) of IgG in blood
8) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764341 Disease Relevance 0.62 Pain Relevance 0
Anti-merozoite IgG levels and clinical outcome for non-parasitized Ndiop inhabitants were correlated after bivariate analysis (P<0.001), but anti-merozoite IgG was no longer significant when age was included in the Poisson regression analysis for the multivariate model (P?
Positive_regulation (outcome) of Gene_expression (levels) of IgG
9) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.15 Pain Relevance 0
For the cytophilic IgG1 and IgG3, there was a marked increase in three to four year old children (Figure 2).
Positive_regulation (increase) of Gene_expression (cytophilic) of IgG3
10) Confidence 0.16 Published 2005 Journal Malar J Section Body Doc Link PMC1262760 Disease Relevance 0.08 Pain Relevance 0
Levels of IgG, which had an oligoclonal pattern, were elevated in the cerebrospinal fluid.
Positive_regulation (elevated) of Gene_expression (Levels) of IgG in cerebrospinal fluid
11) Confidence 0.08 Published 1988 Journal N. Engl. J. Med. Section Abstract Doc Link 3281011 Disease Relevance 1.06 Pain Relevance 0.13
The BAL data are novel and show that subcutaneous polysaccharide vaccination increases mucosal levels of IgG and IgA.
Positive_regulation (increases) of Gene_expression (levels) of IgG
12) Confidence 0.07 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 0.07 Pain Relevance 0
However, the sensitivity of elevated serum IgG4 levels is 63%–68% in other reports.15,16,49 Elevation of serum IgG4 levels has been reported in a patient with pancreatic cancer.50

Radiological findings

Positive_regulation (elevated) of Gene_expression (levels) of IgG4 associated with pancreatic cancer
13) Confidence 0.06 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.14 Pain Relevance 0.03
Some AIP patients show elevated serum IgG4 levels in spite of normal IgG levels.
Positive_regulation (elevated) of Gene_expression (levels) of IgG4 associated with pancreatitis
14) Confidence 0.06 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.32 Pain Relevance 0.03
Recently, a case of a 52-year-old man with retroperitoneal and mediastinal fibrosis who exhibited elevation of serum IgG4 levels in the absence of AIP was reported.14

Lymphadenopathy

Positive_regulation (elevation) of Gene_expression (levels) of IgG4 associated with fibrosis, lymphadenopathy and pancreatitis
15) Confidence 0.05 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.13 Pain Relevance 0.30
Physical examination revealed hepatosplenomegaly, in laboratory tests leukopenia, mild thrombocytopenia, elevated ESR, elevated serum levels of IgG, IgM, IgA, creatine kinase level and hypergammaglobulinaemia were found.
Positive_regulation (elevated) of Gene_expression (levels) of IgG associated with leukopenia and thrombocytopenia
16) Confidence 0.04 Published 2005 Journal Prz. Lek. Section Abstract Doc Link 16334539 Disease Relevance 1.05 Pain Relevance 0.12
An explanation for early IgG production would be the presence of unusually high presymptomatic viremia that provided an early antigen stimulus for antibody formation.
Positive_regulation (explanation) of Gene_expression (production) of IgG associated with viremia
17) Confidence 0.04 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2570846 Disease Relevance 0.16 Pain Relevance 0
Recently, three cases (in a 50-year-old woman, a 56-year-old man, and a 77-year-old man) of sclerosing cholangitis with elevated serum IgG4 levels and dense infiltration of IgG4-positive plasma cells in the bile duct wall but with no apparent pancreatic lesions compatible with AIP were reported.9 It is likely that these patients had an IgG4-related systemic disease with no clinical manifestations other than sclerosing cholangitis.


Positive_regulation (elevated) of Gene_expression (levels) of IgG4 in bile duct associated with bile, pancreatitis, sclerosing cholangitis and disease
18) Confidence 0.04 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.05 Pain Relevance 0.21
Previous studies by this laboratory indicated that beta-endorphin and methionine-enkephalin were potent inhibitors of Staphylococcus aureus, Cowen strain I (SAC)-induced IgG production by human B lymphocytes.
Positive_regulation (-induced) of Gene_expression (production) of IgG in B lymphocytes associated with enkephalin and sprains and strains
19) Confidence 0.03 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8642060 Disease Relevance 0.17 Pain Relevance 0.51
Patients switching from a Privigen study in PID (NCT00322556) were required to have had at least three documented serum IgG trough levels of ?
Positive_regulation (documented) of Gene_expression (levels) of IgG associated with immunodeficiency
20) Confidence 0.03 Published 2010 Journal J Clin Immunol Section Body Doc Link PMC2935975 Disease Relevance 1.28 Pain Relevance 0.20

General Comments

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