INT40034

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Context Info
Confidence 0.80
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.17
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
brain 1
Maoa (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 58 100.00 Very High Very High Very High
Nicotine 11 98.64 Very High Very High Very High
Clonidine 9 98.64 Very High Very High Very High
Serotonin 14 98.16 Very High Very High Very High
tricyclic antidepressant 2 96.40 Very High Very High Very High
Eae 25 92.72 High High
Dopamine 22 92.16 High High
agonist 17 91.52 High High
antidepressant 26 87.12 High High
midbrain 2 83.92 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 89 99.92 Very High Very High Very High
Disease 39 94.68 High High
Death 3 94.32 High High
Nicotine Addiction 3 87.16 High High
Targeted Disruption 2 86.16 High High
Tremor 1 85.72 High High
Movement Disorders 2 85.12 High High
Neurodegenerative Disease 6 78.80 Quite High
Stress 20 72.68 Quite High
Toxicity 2 67.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lortalamine does not modify norepinephrine release, MAO activity nor behaviour of mice.
Localization (release) of MAO
1) Confidence 0.80 Published 1985 Journal Arzneimittelforschung Section Abstract Doc Link 4091869 Disease Relevance 0.19 Pain Relevance 0.28
Among 15 individual or combined MAOIs, including harmane, norharmane, moclobemide, selegiline, pargyline, clorgyline, tranylcypromine and phenelzine, only irreversible inhibitors of both MAO-A and -B (tranylcypromine, phenelzine, and clorgyline+selegiline) allowed a locomotor response to nicotine.
Localization (clorgyline+selegiline) of MAO associated with nicotine
2) Confidence 0.74 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16395299 Disease Relevance 0.26 Pain Relevance 0.70
Effects of adrenergic and cholinergic stimulation on islet monoamine oxidase activity and insulin secretion in the mouse.
Localization (secretion) of islet monoamine oxidase associated with monoamine
3) Confidence 0.73 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.78
These effects on insulin secretion and monoamine oxidase activity could not be blocked by clonidine.
Localization (secretion) of monoamine oxidase associated with clonidine and monoamine
4) Confidence 0.64 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 1.04
We now studied in vivo the relation between adrenergic and cholinergic stimulation, insulin secretion and islet monoamine oxidase activity in the mouse.
Localization (secretion) of islet monoamine oxidase associated with monoamine
5) Confidence 0.64 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8096820 Disease Relevance 0 Pain Relevance 0.63
Measurement of MAO-A and MAO-B activities
Localization (Measurement) of MAO
6) Confidence 0.58 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792615 Disease Relevance 0 Pain Relevance 0.09
Once inside the brain, MPTP is metabolized into the toxic cation 1-methyl-4-phenylpyridinium (MPP+) by the enzyme monoamine oxidase B (MAO-B) in glial cells.
Localization (metabolized) of MAO-B in brain associated with parkinson's disease and monoamine
7) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 1.72 Pain Relevance 0.18

General Comments

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