INT40036

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Context Info
Confidence 0.36
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.88
Pain Relevance 3.95

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cell differentiation (DLL1) extracellular region (DLL1) plasma membrane (DLL1)
cell-cell signaling (DLL1)
Anatomy Link Frequency
Notch 2
cerebral cortex 1
muscle 1
DLL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Delta-9-tetrahydrocannabinol 2 100.00 Very High Very High Very High
Analgesic 7 99.98 Very High Very High Very High
Opioid 13 99.74 Very High Very High Very High
opioid receptor 8 99.48 Very High Very High Very High
Pain 9 99.36 Very High Very High Very High
Serotonin 2 99.30 Very High Very High Very High
cerebral cortex 3 99.20 Very High Very High Very High
Morphine 8 98.88 Very High Very High Very High
antagonist 4 98.20 Very High Very High Very High
Enkephalin 3 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Eating Disorder 4 99.76 Very High Very High Very High
Neuroblastoma 7 97.96 Very High Very High Very High
Pain 7 93.04 High High
Thyroid Neoplasm 249 92.72 High High
Genetic Predisposition To Disease 1 91.00 High High
Manic Depressive Disorder 2 84.68 Quite High
Cancer 88 76.88 Quite High
Bordatella Infection 3 66.16 Quite High
Non-small-cell Lung Cancer 3 58.00 Quite High
Pancreatic Cancer 1 54.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN).
delta 1 Binding (association) of associated with opioid, serotonin and eating disorder
1) Confidence 0.36 Published 2007 Journal Biol. Psychiatry Section Abstract Doc Link 16806108 Disease Relevance 0.45 Pain Relevance 0.15
AcChRs from Torpedo and Electrophorus electric organ and from piscine, avian, and mammalian muscle have been shown to be highly conserved proteins composed of four types of homologous subunits (alpha, beta, gamma, and delta) which associate in a stoichiometry alpha 2 beta 1 gamma 1 delta 1 to form a pseudosymmetric pentameric complex molecule.
delta 1 Binding (associate) of in muscle
2) Confidence 0.35 Published 1985 Journal Fundam Appl Toxicol Section Abstract Doc Link 4092895 Disease Relevance 0 Pain Relevance 0
Together these results provide several lines of evidence that the Ca(V)alpha(2)delta-1 auxiliary subunit may interact with Ca(V)1.3 channels and regulate their functional expression.
delta-1 Binding (interact) of
3) Confidence 0.35 Published 2009 Journal Cell Calcium Section Abstract Doc Link 19796812 Disease Relevance 0 Pain Relevance 0.18
In this study, receptor binding profiles of opioid ligands for subtypes of opioid delta-receptors were examined employing [3H]D-Pen2,D-Pen5-enkephalin ([3H]DPDPE) and [3H]Ile(5,6)-deltorphin II ([3H]Ile-Delt II) in human cerebral cortex membranes. [3H]DPDPE, a representative ligand for delta1 sites, labeled a single population of binding sites with apparent affinity constant (Kd) of 2.72 +/- 0.21 nM and maximal binding capacity (Bmax) value of 20.78 +/- 3.13 fmol/mg protein.
delta1 Binding (ligand) of in cerebral cortex associated with enkephalin, cerebral cortex and opioid
4) Confidence 0.26 Published 2001 Journal Life Sci. Section Abstract Doc Link 11263677 Disease Relevance 0 Pain Relevance 0.51
Binding of any one of the Notch ligands (e.g., DLL-1 or JAG-1) promotes a sequence of proteolytic cleavages resulting in the activated Notch intracellular domain (NICD).
DLL-1 Binding (Binding) of in Notch
5) Confidence 0.11 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.88 Pain Relevance 0
Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine.
delta Binding (interaction) of associated with analgesic, delta-9-tetrahydrocannabinol and morphine
6) Confidence 0.10 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16375890 Disease Relevance 0.25 Pain Relevance 1.52
Binding of any one of the Notch ligands (Delta1 (DLL-1) or Jagged1 (JAG-1), for example) promotes a sequence of proteolytic cleavages resulting in the activated Notch intracellular domain (NICD).
DLL-1 Binding (Binding) of in Notch
7) Confidence 0.09 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.73 Pain Relevance 0
Biochemical and pharmacological characterization of mu, delta and kappa 3 opioid receptors expressed in BE(2)-C neuroblastoma cells.
delta Binding (characterization) of associated with neuroblastoma and opioid receptor
8) Confidence 0.07 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7932177 Disease Relevance 0.19 Pain Relevance 0.55
Selective assays reveal a binding distribution of mu (38%), delta (16%) and kappa 3 (43%) opioid receptors.
delta Binding (binding) of associated with opioid receptor
9) Confidence 0.07 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932177 Disease Relevance 0.17 Pain Relevance 0.47
Delta and mu binding are defined easily by traditional selective ligands.
Delta Binding (binding) of
10) Confidence 0.07 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932177 Disease Relevance 0.21 Pain Relevance 0.58

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