INT4004

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Context Info
Confidence 0.71
First Reported 1976
Last Reported 2010
Negated 14
Speculated 5
Reported most in Body
Documents 321
Total Number 325
Disease Relevance 221.03
Pain Relevance 42.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHG3)
Anatomy Link Frequency
plasma cells 17
blood 10
B cells 8
T-cell 7
cerebrospinal fluid 6
IGHG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 417 100.00 Very High Very High Very High
Morphine 198 100.00 Very High Very High Very High
intrathecal 186 100.00 Very High Very High Very High
Central nervous system 154 100.00 Very High Very High Very High
rheumatoid arthritis 923 99.96 Very High Very High Very High
opioid receptor 7 99.84 Very High Very High Very High
Multiple sclerosis 823 99.76 Very High Very High Very High
metalloproteinase 165 99.74 Very High Very High Very High
fibrosis 1839 99.66 Very High Very High Very High
Inflammation 1611 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 2950 100.00 Very High Very High Very High
Malaria 2207 100.00 Very High Very High Very High
Bacillus Anthracis Infection 228 100.00 Very High Very High Very High
Epstein-barr Virus 152 100.00 Very High Very High Very High
Mycobacterial Infection 139 100.00 Very High Very High Very High
Stress 135 100.00 Very High Very High Very High
Testicular Cancer 7 100.00 Very High Very High Very High
Neuromyelitis Optica 710 99.98 Very High Very High Very High
Dengue 472 99.98 Very High Very High Very High
Rheumatoid Arthritis 933 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most patients with proven or suspected enteric infection with the common hookworm of dogs, Ancylostoma caninum, produce immunoglobulin G (IgG) and IgE antibodies to an immunodominant excretory/secretory antigen (Ac68) of the parasite.
Gene_expression (produce) of IgG in excretory associated with ancylostoma infection, hookworm infection and infection
1) Confidence 0.71 Published 1996 Journal Am. J. Trop. Med. Hyg. Section Abstract Doc Link 8686791 Disease Relevance 0.50 Pain Relevance 0
After 2001, many reports have shown that serum IgG4 levels specifically elevate in patients with autoimmune pancreatitis (AIP), suggesting its clinical usefulness in discrimination between AIP and pancreatic cancer.
Gene_expression (levels) of IgG4 associated with pancreatic cancer and pancreatitis
2) Confidence 0.71 Published 2010 Journal Rinsho Byori Section Abstract Doc Link 20496768 Disease Relevance 0.69 Pain Relevance 0.08
To confirm this, we tried to examine a utility of IgG4 by measuring serum IgG4 levels of patients with healthy human, AIP, chronic pancreatitis, pancreatic cancer and autoimmune disease with nephelometric immunoassay (NIA).
Gene_expression (levels) of IgG4 associated with autoimmune disease, pancreatic cancer, pancreatitis and chronic pancreatitis
3) Confidence 0.71 Published 2010 Journal Rinsho Byori Section Abstract Doc Link 20496768 Disease Relevance 0.83 Pain Relevance 0.10
Our results show in contrast that the production of polyclonal IgG was associated with protection in asymptomatic parasite carriers, and that polyclonal reactions appeared to have at least short-term protective effects.
Gene_expression (production) of IgG
4) Confidence 0.71 Published 2005 Journal Malar J Section Body Doc Link PMC548665 Disease Relevance 0.40 Pain Relevance 0
Importantly however, any overlap between NRF and CRF could be excluded based on the following arguments: (a) Western blotting shows no IgG4 Fab- Ig Fc (CRF) interaction and (b) ELISA showed that serum level of IgG4 bound to each IgG subclass correlated well with the serum IgG4 level itself (i.e. the totality of IgG4-Ig interaction is through Fc-Fc engagement), and (c) the reciprocal absence of any link between IgG-bound IgG4 levels and RF, excluding therefore any CRF reactivity (Figure 5).
Neg (no) Gene_expression (blotting) of IgG4
5) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.21 Pain Relevance 0.08
The concentrations of standards were expressed as IgG4 values from the pooled patient sera.
Gene_expression (expressed) of IgG4
6) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.21 Pain Relevance 0
The linear correlation was obtained for each assay system between the absorbance of IgG4 bound to each IgG subclass and the IgG4 value from the pooled sera.
Gene_expression (absorbance) of IgG4
7) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.23 Pain Relevance 0
RF are anti-IgG antibodies of mainly IgM but also IgG (or other) isotypes [4].
Gene_expression (antibodies) of IgG
8) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.75 Pain Relevance 0.13
Importantly however, any overlap between NRF and CRF could be excluded based on the following arguments: (a) Western blotting shows no IgG4 Fab- Ig Fc (CRF) interaction and (b) ELISA showed that serum level of IgG4 bound to each IgG subclass correlated well with the serum IgG4 level itself (i.e. the totality of IgG4-Ig interaction is through Fc-Fc engagement), and (c) the reciprocal absence of any link between IgG-bound IgG4 levels and RF, excluding therefore any CRF reactivity (Figure 5).
Gene_expression (levels) of IgG4
9) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.16 Pain Relevance 0.08
RF are anti-IgG antibodies of mainly IgM but also IgG (or other) isotypes [4].
Gene_expression (antibodies) of IgG
10) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.75 Pain Relevance 0.14
IgG4, quantitatively the least prevalent of all human IgG subclasses, has two unique features: not being able to activate the classical complement pathway and to bind antigen with low affinity [22].
Gene_expression (subclasses) of IgG
11) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 1.58 Pain Relevance 0.11
Is it limited to IgG4 or could be found for other IgG subclasses or Ig classes?
Gene_expression (subclasses) of IgG
12) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.32 Pain Relevance 0.03
IgG4, quantitatively the least prevalent of all human IgG subclasses, has two unique features: not being able to activate the classical complement pathway and to bind antigen with low affinity [22].
Gene_expression (prevalent) of IgG4
13) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 1.61 Pain Relevance 0.11
Importantly however, any overlap between NRF and CRF could be excluded based on the following arguments: (a) Western blotting shows no IgG4 Fab- Ig Fc (CRF) interaction and (b) ELISA showed that serum level of IgG4 bound to each IgG subclass correlated well with the serum IgG4 level itself (i.e. the totality of IgG4-Ig interaction is through Fc-Fc engagement), and (c) the reciprocal absence of any link between IgG-bound IgG4 levels and RF, excluding therefore any CRF reactivity (Figure 5).
Neg (no) Gene_expression (blotting) of IgG4
14) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.20 Pain Relevance 0.07
These findings show that the production of IgG3 antibodies that recognize MSP3 is strongly associated with the development of long-lasting natural protection against malaria.
Gene_expression (production) of IgG3 associated with malaria
15) Confidence 0.64 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC2071934 Disease Relevance 0.96 Pain Relevance 0
When they analyzed their data, they found that only one immune response—the production of antibodies of the IgG3 isotype directed against an antigen called merozoite surface protein 3 (MSP3)—was strongly associated with clinical protection against malaria in all age groups.
Gene_expression (production) of IgG3 isotype associated with malaria
16) Confidence 0.64 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC2071934 Disease Relevance 0.98 Pain Relevance 0
Direct immunofluorescence showed IgG deposition in the intercellular spaces of the epidermis and linear C3 deposition in the basement-membrane zone.
Gene_expression (deposition) of IgG in epidermis
17) Confidence 0.62 Published 2008 Journal Dermatol. Online J. Section Abstract Doc Link 18713592 Disease Relevance 0.43 Pain Relevance 0.09
These antibodies were detected in both enzyme-linked immunosorbent assay (ELISA) and Western blots; the Western blot to detect IgG antibodies to Ac68 was the most specific and sensitive.
Gene_expression (detect) of IgG
18) Confidence 0.62 Published 1996 Journal Am. J. Trop. Med. Hyg. Section Abstract Doc Link 8686791 Disease Relevance 0.77 Pain Relevance 0.05
These results indicate the Western blot to detect IgG4 antibodies to Ac68 is the most reliable immunodiagnostic test yet described for enteric infection with A. caninum, although this test does not discriminate between infections with human and canine hookworms.
Gene_expression (detect) of IgG4 associated with infection
19) Confidence 0.62 Published 1996 Journal Am. J. Trop. Med. Hyg. Section Abstract Doc Link 8686791 Disease Relevance 0.87 Pain Relevance 0.07
The gradual acquisition of clinical immunity to malaria after repeated infection is positively correlated with the development of a diverse IgG repertoire, most clearly including IgG reactive to parasitized red blood cells [1].
Gene_expression (reactive) of IgG in red blood cells associated with malaria and infection
20) Confidence 0.62 Published 2005 Journal Malar J Section Body Doc Link PMC548665 Disease Relevance 0.26 Pain Relevance 0

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