INT40053

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Context Info
Confidence 0.54
First Reported 1974
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 4.41
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Anatomy Link Frequency
plasma 4
mesangial cells 2
heart 2
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 8 97.64 Very High Very High Very High
cINOD 3 85.60 High High
Clonidine 3 80.96 Quite High
Calcium channel 5 78.00 Quite High
COX-2 inhibitor 3 75.96 Quite High
antagonist 25 73.20 Quite High
headache 9 71.00 Quite High
Inflammation 12 70.04 Quite High
metalloproteinase 8 59.68 Quite High
Kinase C 10 49.16 Quite Low
Disease Link Frequency Relevance Heat
Renal Disease 92 100.00 Very High Very High Very High
Fibrosis 12 97.64 Very High Very High Very High
Heart Rate Under Development 3 97.08 Very High Very High Very High
Diabetes Mellitus 113 96.36 Very High Very High Very High
Disease 32 95.68 Very High Very High Very High
Pressure And Volume Under Development 19 85.88 High High
INFLAMMATION 11 85.36 High High
Chronic Renal Failure 256 83.52 Quite High
Increased Venous Pressure Under Development 5 83.04 Quite High
Weight Gain 2 71.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many clinical and laboratory studies have demonstrated that it is the estrogen content of ovulation inhibitors that is responsible for the increased plasma renin activity.
Positive_regulation (responsible) of Positive_regulation (increased) of plasma renin in plasma
1) Confidence 0.54 Published 1974 Journal Med Klin Section Abstract Doc Link 4374645 Disease Relevance 1.24 Pain Relevance 0.07
Additionally, activation of Src family members by G-protein-coupled receptors may increase ERK1/2 phosphorylation via activation of the renin angiotensin system (Ras) [17, 18] or via transactivation of the EGFR [26].
Spec (may) Positive_regulation (increase) of Positive_regulation (activation) of renin
2) Confidence 0.49 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583213 Disease Relevance 0 Pain Relevance 0.06
This study provides definitive evidence that metabolites of COX-2 rather than COX-1 mediate ACEI-induced renin increases.
Positive_regulation (mediate) of Positive_regulation (increases) of renin
3) Confidence 0.34 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0 Pain Relevance 0.04
Because renin increases are mediated by cAMP, we also examined whether increased renin is mediated by the prostaglandin E(2) receptor EP(2) subtype, which is coupled to G(s) and increases cAMP.
Spec (whether) Positive_regulation (mediated) of Spec (whether) Positive_regulation (increased) of renin
4) Confidence 0.31 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0.08 Pain Relevance 0.08
Because renin increases are mediated by cAMP, we also examined whether increased renin is mediated by the prostaglandin E(2) receptor EP(2) subtype, which is coupled to G(s) and increases cAMP.
Positive_regulation (mediated) of Spec (examined) Positive_regulation (increases) of renin
5) Confidence 0.31 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0.09 Pain Relevance 0.09
Although more research is needed, activation of the (pro)renin receptor may contribute to the pathology of renal disease by increasing local Ang II formation and by increasing the expression of profibrotic mediators.
Positive_regulation (increasing) of Positive_regulation (activation) of renin associated with renal disease
6) Confidence 0.28 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.91 Pain Relevance 0.07
Although more research is needed, activation of the (pro)renin receptor may contribute to the pathology of renal disease by increasing local Ang II formation and by increasing the expression of profibrotic mediators.
Positive_regulation (increasing) of Positive_regulation (activation) of renin associated with renal disease
7) Confidence 0.28 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.93 Pain Relevance 0.07
Activation of the (pro)renin receptor in mesangial cells also activates mitogen-activated protein kinase, ERK 1 and 2 and several fibrosis/remodeling mediators such as TGF?
Positive_regulation (activates) of Positive_regulation (Activation) of renin in mesangial cells associated with fibrosis
8) Confidence 0.28 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.67 Pain Relevance 0.08
Unlike ACE inhibitors, ARBs and other antihypertensive agents that cause an increase in plasma renin activity, aliskiren directly inhibits the catalytic activity of renin, thus reducing plasma renin activity and, in turn, the production of Ang II and aldosterone [63].
Positive_regulation (cause) of Positive_regulation (increase) of plasma renin in plasma
9) Confidence 0.22 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.31 Pain Relevance 0.16
Neurohormonal activation with increased plasma renin activity and norepinephrine and vasopressin levels is characteristic of congestive heart failure and contributes to further decompensation and poor prognosis.
Positive_regulation (activation) of Positive_regulation (increased) of plasma renin in heart associated with heart rate under development
10) Confidence 0.01 Published 1995 Journal Hypertension Section Abstract Doc Link 7591009 Disease Relevance 0.17 Pain Relevance 0.08

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