INT40084

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Context Info
Confidence 0.36
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 9.15
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (HBS1L) translation (HBS1L) GTPase activity (HBS1L)
HBS1L (Homo sapiens)
Pain Link Frequency Relevance Heat
pruritus 2 96.96 Very High Very High Very High
Pain 25 95.32 Very High Very High Very High
headache 6 87.28 High High
Inflammation 5 69.52 Quite High
Analgesic 1 67.20 Quite High
tolerance 4 63.68 Quite High
cytokine 42 7.40 Low Low
agonist 4 5.00 Very Low Very Low Very Low
Acute pain 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 99 100.00 Very High Very High Very High
Immunization 37 100.00 Very High Very High Very High
Hepatitis 35 100.00 Very High Very High Very High
Thalassemia 25 100.00 Very High Very High Very High
Hepatitis C Virus Infection 17 100.00 Very High Very High Very High
Sickle Cell Anemia 52 99.88 Very High Very High Very High
Hemolysis 57 98.20 Very High Very High Very High
Malaria 66 97.60 Very High Very High Very High
Hepatitis B Virus Infection 85 97.28 Very High Very High Very High
Pruritus 2 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apart from several other abnormal haemoglobin gene-combinations, such as beta-thalassaemia, sickle cell disease is found in individuals with homozygote HbSS (sickle cell anaemia) and heterozygote SC genotypes, whereas the inheritance of two C-alleles (HbCC) or one A plus one C or S allele (HbAS and HbAC) give rise to phenotypes associated with limited pathology [1].
HbS Binding (individuals) of associated with sickle cell anemia and thalassemia
1) Confidence 0.36 Published 2005 Journal Malar J Section Body Doc Link PMC1326224 Disease Relevance 0.77 Pain Relevance 0.03
Genotyping of HbS and ?
HbS Binding (Genotyping) of
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894056 Disease Relevance 0.10 Pain Relevance 0
Out of the 400 IDUs enrolled, 398 consented for HIV, HCV, and hepatitis B surface antigen (HbsAg) test.
HbsAg Binding (consented) of associated with acquired immune deficiency syndrome or hiv infection, hepatitis c virus infection and hepatitis
3) Confidence 0.20 Published 2009 Journal AIDS Care Section Abstract Doc Link 20024719 Disease Relevance 2.05 Pain Relevance 0.07
HbS was also associated with an increase in gametocyte density in Dielmo, explaining 2.4% of the variation in this trait.
HbS Binding (associated) of
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894056 Disease Relevance 0.48 Pain Relevance 0
This is consistent with HbF’s ability to inhibit HbS polymerization, thereby decreasing either vasoocclusion or hemolysis [27].
HbS Binding (polymerization) of associated with hemolysis
5) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2330070 Disease Relevance 1.72 Pain Relevance 0.18
One subject from the HBsAg plus 100 ?
HBsAg Binding (subject) of
6) Confidence 0.02 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.92 Pain Relevance 0.33
Following immunization with HBsAg alone, induction of low anti-HBsAg antibodies titres, not allowing seroprotection was observed in two out of 7 naïve subjects (28.5 %) (Table 3).
HBsAg Binding (immunization) of associated with immunization
7) Confidence 0.02 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.49 Pain Relevance 0
Subjects with HBsAg and anti-HBc total antibodies were defined as being chronic HBsAg carriers.
HBsAg Binding (Subjects) of
8) Confidence 0.02 Published 2005 Journal J Int AIDS Soc Section Body Doc Link PMC2740790 Disease Relevance 1.47 Pain Relevance 0
Interaction between HBS-beta-o-thalassemia and alpha-thalassemia.
HBS-beta-o-thalassemia Binding (Interaction) of associated with thalassemia
9) Confidence 0.00 Published 1984 Journal Am. J. Med. Sci. Section Title Doc Link 6083725 Disease Relevance 1.17 Pain Relevance 0.08

General Comments

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