INT40104

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Context Info
Confidence 0.38
First Reported 1984
Last Reported 2008
Negated 1
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 4.56
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cysltr1) plasma membrane (Cysltr1) signal transducer activity (Cysltr1)
Anatomy Link Frequency
sputum 1
spines 1
soma 1
Cysltr1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 124 100.00 Very High Very High Very High
antagonist 97 100.00 Very High Very High Very High
qutenza 12 99.60 Very High Very High Very High
Inflammation 42 81.04 Quite High
Neuropeptide 2 67.80 Quite High
aspirin 14 64.72 Quite High
Pyramidal cell 2 59.64 Quite High
tolerance 55 50.00 Quite Low
long-term potentiation 37 46.52 Quite Low
corticosteroid 114 40.68 Quite Low
Disease Link Frequency Relevance Heat
Depression 124 100.00 Very High Very High Very High
Asthma 306 96.96 Very High Very High Very High
Chronic Disease 6 94.72 High High
Anaphylaxis 2 94.64 High High
Rhinitis 16 92.72 High High
Edema 2 85.36 High High
INFLAMMATION 46 81.04 Quite High
Dyspnea 4 67.12 Quite High
Disease 27 58.80 Quite High
Pulmonary Disease 7 52.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no interaction between LTD4 and H on bronchomotor tone in capsaicin-pretreated guinea-pigs.
LTD4 Neg (no) Binding (interaction) of associated with qutenza
1) Confidence 0.38 Published 1984 Journal Agents Actions Section Abstract Doc Link 6085218 Disease Relevance 0 Pain Relevance 0.40
By competitive binding to the Cys-LT(1) receptor, leukotriene receptor antagonist drugs such as montelukast, zafirlukast, and pranlukast, block the effects of Cys-LTs and alleviate the symptoms of many chronic diseases, especially bronchial asthma and allergic rhinitis.
Cys-LT Binding (binding) of associated with asthma, rhinitis, antagonist and chronic disease
2) Confidence 0.34 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17691939 Disease Relevance 0.63 Pain Relevance 0.08
CysLT and PGE2 were extracted from induced sputum supernatants by immunoaffinity purification using affinity sorbents (mouse monoclonal cysLT or PGE2 antibody covalently bound to Sepharose 4B, Cayman Chemical, Ann Arbor, MI, USA).
cysLT Binding (bound) of in sputum
3) Confidence 0.34 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2426667 Disease Relevance 0 Pain Relevance 0
By competitive binding to the Cys-LT(1) receptor, leukotriene receptor antagonist drugs such as montelukast, zafirlukast, and pranlukast, block the effects of Cys-LTs and alleviate the symptoms of many chronic diseases, especially bronchial asthma and allergic rhinitis.
leukotriene receptor Binding (binding) of associated with asthma, rhinitis, antagonist and chronic disease
4) Confidence 0.32 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17691939 Disease Relevance 0.71 Pain Relevance 0.08
Total CysLT (LTC4/LTD4/LTE4) and PGE2 concentrations were determined with specific enzyme immunoassay kits according to the manufacturer's instructions (Cayman Chemical).
LTD4 Spec (determined) Binding (determined) of
5) Confidence 0.30 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2426667 Disease Relevance 0 Pain Relevance 0
However, the failure of LTD4 to enhance bronchoconstriction due to ACh or vagal stimulation, together with the prevention of the interaction between LTD4 and H by capsaicin-pretreatment, suggests that the site of the interaction may be on capsaicin-sensitive afferent neurones.
LTD4 Binding (interaction) of associated with qutenza
6) Confidence 0.28 Published 1984 Journal Agents Actions Section Abstract Doc Link 6085218 Disease Relevance 0 Pain Relevance 0.44
They exert important pharmacological effects by interaction with at least two different receptors: Cys-LT(1) and Cys-LT(2).
Cys-LT Binding (interaction) of
7) Confidence 0.28 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17691939 Disease Relevance 0.48 Pain Relevance 0.08
They exert important pharmacological effects by interaction with at least two different receptors: Cys-LT(1) and Cys-LT(2).
Cys-LT Binding (interaction) of
8) Confidence 0.28 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17691939 Disease Relevance 0.43 Pain Relevance 0.08
Total CysLT (LTC4/LTD4/LTE4) and PGE2 concentrations were determined with specific enzyme immunoassay kits according to the manufacturer's instructions (Cayman Chemical).
CysLT Spec (determined) Binding (determined) of
9) Confidence 0.26 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2426667 Disease Relevance 0 Pain Relevance 0
The leukotriene receptor antagonists (LTRAs) selectively block the binding of cysteinyl leukotrienes to the CysLT1 receptor, which has been identified as the receptor through which most of their actions are mediated (Drazen et al 1999).
CysLT1 receptor Binding (binding) of associated with antagonist
10) Confidence 0.23 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376066 Disease Relevance 0.92 Pain Relevance 0.26
The leukotriene receptor antagonists (LTRAs) selectively block the binding of cysteinyl leukotrienes to the CysLT1 receptor, which has been identified as the receptor through which most of their actions are mediated (Drazen et al 1999).
leukotriene receptor Binding (binding) of associated with antagonist
11) Confidence 0.18 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376066 Disease Relevance 0.93 Pain Relevance 0.27
In a previous study of LTD-based pattern recognition in a nonspiking Purkinje-cell model with a passive soma, we observed the best performance for PF patterns where N = 1000 inputs (i.e., approximately 0.7% of the 147,400 inputs) were active synchronously (Steuber and De Schutter, 2001).
LTD Binding (recognition) of in soma associated with depression
12) Confidence 0.03 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.10 Pain Relevance 0.05
It has been shown that LTD is associated with structural reorganization and a retraction of dendritic spines (Nagerl et al. 2004; Zhou et al. 2004; Bastrikova et al. 2008).
LTD Binding (associated) of in spines associated with depression
13) Confidence 0.01 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.36 Pain Relevance 0.21

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