INT40114

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Context Info
Confidence 0.00
First Reported 1984
Last Reported 1998
Negated 2
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 4.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1, Oprm1) signal transducer activity (OPRD1, Oprm1) signal transduction (Oprm1)
cytoplasm (OPRD1)
OPRD1 (Homo sapiens)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 6 99.84 Very High Very High Very High
Opioid 28 99.08 Very High Very High Very High
Enkephalin 8 96.12 Very High Very High Very High
Morphine 3 95.08 Very High Very High Very High
agonist 4 94.72 High High
analgesia 3 92.52 High High
Immobilon 4 92.32 High High
nalbuphine 2 91.16 High High
butorphanol 4 90.68 High High
antagonist 1 83.56 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggested that in the hot plate test, there is no modulation of the effect resulting from mu-receptor stimulation by a delta-receptor interaction.
delta-receptor Binding (interaction) of mu-receptor
1) Confidence 0.00 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6086366 Disease Relevance 0 Pain Relevance 1.31
There was no relationship between the substitution patterns produced by these opioids and their relative intrinsic efficacy at the mu receptor, their relative selectivity for the mu receptor or their relative affinity for the delta receptor.
delta receptor Neg (no) Binding (affinity) of mu receptor associated with opioid
2) Confidence 0.00 Published 1998 Journal Behav Pharmacol Section Abstract Doc Link 10065920 Disease Relevance 0 Pain Relevance 1.48
There was no relationship between the substitution patterns produced by these opioids and their relative intrinsic efficacy at the mu receptor, their relative selectivity for the mu receptor or their relative affinity for the delta receptor.
delta receptor Neg (no) Binding (affinity) of mu receptor associated with opioid
3) Confidence 0.00 Published 1998 Journal Behav Pharmacol Section Abstract Doc Link 10065920 Disease Relevance 0 Pain Relevance 1.50

General Comments

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