INT4012

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Context Info
Confidence 0.52
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 14.12
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Psd) intracellular (Psd) cytoplasm (Psd)
Anatomy Link Frequency
Shank 2
fat 1
spinal cord 1
finger 1
adipose tissue 1
Psd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 247 100.00 Very High Very High Very High
Spinal cord 8 100.00 Very High Very High Very High
anesthesia 3 99.26 Very High Very High Very High
Hyperalgesia 1 97.24 Very High Very High Very High
sSRI 48 96.96 Very High Very High Very High
Peripheral nerve injury 3 95.36 Very High Very High Very High
Eae 2 95.20 Very High Very High Very High
Lasting pain 4 94.08 High High
Duloxetine 3 93.92 High High
behavioral therapy 3 92.40 High High
Disease Link Frequency Relevance Heat
Depression 285 100.00 Very High Very High Very High
Dementia 224 100.00 Very High Very High Very High
Hyperlipidemia 222 99.84 Very High Very High Very High
Pancreatitis 242 99.44 Very High Very High Very High
Spinal Cord Injury 9 99.02 Very High Very High Very High
Stroke 335 99.00 Very High Very High Very High
Obesity 33 97.76 Very High Very High Very High
Hyperalgesia 1 97.24 Very High Very High Very High
Syndrome 23 95.08 Very High Very High Very High
Nervous System Injury 3 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With anesthesia of the finger vasomotor nerves, the PSD was reduced in both groups.
Negative_regulation (reduced) of PSD in finger associated with anesthesia
1) Confidence 0.52 Published 1986 Journal Scand J Work Environ Health Section Abstract Doc Link 2946076 Disease Relevance 0.23 Pain Relevance 0.30
Prevention of PSD
Negative_regulation (Prevention) of PSD associated with depression
2) Confidence 0.48 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515899 Disease Relevance 0.60 Pain Relevance 0.52
The present results indicate that the deficiency of spinal cord PSD-93/chapsin-110 protein significantly attenuates thermal and mechanical hyperalgesia in complete Freund's adjuvant- or peripheral nerve injury-induced chronic pain.
Negative_regulation (deficiency) of PSD-93 in spinal cord associated with hyperalgesia, nervous system injury, lasting pain, peripheral nerve injury and spinal cord
3) Confidence 0.38 Published 2003 Journal Pain Section Abstract Doc Link 14581127 Disease Relevance 0.76 Pain Relevance 1.05
Shorter periods of EFA deficiency resulted in similar diminished 35S incorporation.
Negative_regulation (deficiency) of EFA
4) Confidence 0.38 Published 1976 Journal J. Rheumatol. Section Abstract Doc Link 950638 Disease Relevance 0 Pain Relevance 0.08
SCI vehicle-treated rats demonstrated a significant decrease in total rearing time on PSD 14 and by PSD 28 significant differences in total activities where seen in all parameters measured.
Negative_regulation (decrease) of PSD associated with spinal cord injury
5) Confidence 0.36 Published 2001 Journal J. Neurotrauma Section Abstract Doc Link 11686495 Disease Relevance 1.26 Pain Relevance 0.82
Moreover, data from a more recent trial showed that sertraline treatment, 50 mg/day, had no advantage in comparison to placebo in preventing PSD (Almeida et al 2006).
Negative_regulation (preventing) of PSD associated with depression
6) Confidence 0.35 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515899 Disease Relevance 0.74 Pain Relevance 0.48
Controlled studies on the effectiveness of ADs in PSD are relatively few, and they are essentially related to the use of TCAs or SSRIs (Table 3).
Negative_regulation (effectiveness) of PSD associated with depression and ssri
7) Confidence 0.35 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515899 Disease Relevance 0.55 Pain Relevance 0.37
In contrast, some studies found that not only the risk of PSD is high immediately after stroke but also remains higher in patients nondemented three months after stroke.11 Even among patients who remain cognitively intact, hospital-based and population-based studies have revealed a significant risk for developing delayed dementia.5,12,13 In community-based studies, the prevalence of PSD is about 30% and the incidence of new onset dementia after stroke increases from 7% after one year to 48% after 25 years.6
Negative_regulation (prevalence) of PSD associated with dementia and stroke
8) Confidence 0.24 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695209 Disease Relevance 2.32 Pain Relevance 0
In addition, the prevalence of PSD may decline years after stroke.
Negative_regulation (prevalence) of PSD associated with dementia and stroke
9) Confidence 0.24 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695209 Disease Relevance 2.76 Pain Relevance 0
Thus, the parallel changes in Shank1 upon manipulation of TRIM3 could be explained by decreased stabilization of Shank at the PSD secondary to GKAP loss.
Negative_regulation (stabilization) of PSD in Shank
10) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
The mechanism likely involves the direct or indirect loss of PSD scaffold proteins such as GKAP and Shank, as Shank1 strongly promotes spine head enlargement [25].
Negative_regulation (loss) of PSD in Shank
11) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
Interestingly, PSD-95 loss is also a hallmark sign of neurodegeneration (Gardoni 2008; Gardoni et al. 2009); hence, uncoupling or disruption of the PSD may be an important step in synaptic dysfunction and damage.
Negative_regulation (loss) of PSD
12) Confidence 0.11 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.47 Pain Relevance 0.10
Several reports have documented a reversal of biochemical and clinical manifestations of EFA deficiency in infants and adults by cutaneous administration of EFA-rich oil, such as sunflower oil [29-35].
Negative_regulation (deficiency) of EFA
13) Confidence 0.01 Published 2004 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC544881 Disease Relevance 0.07 Pain Relevance 0
A ratio of ETA to AA > 0.2, is suggestive of EFA deficiency [24-26].
Negative_regulation (deficiency) of EFA
14) Confidence 0.01 Published 2004 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC544881 Disease Relevance 0.17 Pain Relevance 0
Therefore, application of sunflower oil to the proband's skin was initiated at week 25 and may have had prevented progression of EFA deficiency in mother, as suggested by the stabilization of the 20:3(n-9) to 20:4(n-6) ratio.
Negative_regulation (deficiency) of EFA in skin
15) Confidence 0.01 Published 2004 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC544881 Disease Relevance 0.11 Pain Relevance 0
In the case of life long low oral fat intake, as in our patient, clinical EFA deficiency might occur with depletion of n-3 and n-6 FA stored in adipose tissue.
Negative_regulation (deficiency) of EFA in adipose tissue associated with obesity
16) Confidence 0.00 Published 2004 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC544881 Disease Relevance 0.40 Pain Relevance 0
Outcome goals were clearly set at the onset of her pregnancy care, including nutritional management of the expected rise in triglyceride levels associated with the estrogen surge of pregnancy to prevent acute pancreatitis, and avoidance of clinical EFA deficiency in both the mother and the fetus.
Negative_regulation (deficiency) of EFA associated with pancreatitis
17) Confidence 0.00 Published 2004 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC544881 Disease Relevance 1.13 Pain Relevance 0.03
The strategies utilized to prevent EFA deficiency and the fetal nutritional information obtained from studies at birth will address these questions and concerns.


Negative_regulation (deficiency) of EFA
18) Confidence 0.00 Published 2004 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC544881 Disease Relevance 0.67 Pain Relevance 0.05
The proband did not develop signs of clinical EFA deficiency, nor did the ratio of 20:3(n-9) to 20:4(n-6) exceed 0.2 at any stage of her pregnancy, although an upward trend did occur.
Negative_regulation (deficiency) of EFA
19) Confidence 0.00 Published 2004 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC544881 Disease Relevance 0.14 Pain Relevance 0
Very low fat diet and EFA deficiency
Negative_regulation (deficiency) of EFA in fat
20) Confidence 0.00 Published 2004 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC544881 Disease Relevance 0.43 Pain Relevance 0

General Comments

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