INT40128

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Context Info
Confidence 0.27
First Reported 1984
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 0.67
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Noc2l) histone binding (Noc2l) nucleolus (Noc2l)
nucleus (Noc2l)
Anatomy Link Frequency
spleen 1
Noc2l (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 297 100.00 Very High Very High Very High
Enkephalin 18 100.00 Very High Very High Very High
Deep tissue 9 99.48 Very High Very High Very High
ischemia 11 81.92 Quite High
isoflurane 18 75.12 Quite High
anesthesia 15 73.64 Quite High
ketamine 2 72.48 Quite High
Multiple sclerosis 12 7.40 Low Low
rheumatoid arthritis 12 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 16 87.28 High High
Cv Unclassified Under Development 11 81.92 Quite High
Immunization 2 75.60 Quite High
Animal Disease Models 4 68.08 Quite High
B-cell Lymphoma 4 47.64 Quite Low
Lymphatic System Cancer 12 46.56 Quite Low
Systemic Lupus Erythematosus 20 35.72 Quite Low
Disease 20 33.88 Quite Low
Adhesions 3 13.48 Low Low
Cancer 7 8.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The red filter set (excitation range 615 to 665 nm; emission, 700 nm longpass) was used to detect Alexa680-SPIO and the near infrared filter set (excitation range 710 to 760 nm; emission, 800 nm longpass) enabled detection of the cell membrane bound NIR815.
NIR815 Binding (bound) of
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0 Pain Relevance 0.32
Cells were also labeled with a lipophilic membrane associating dye, CellVue NIR 815 (NIR815), to enable deep tissue fluorescent imaging (Fig. 1B).
NIR Binding (associating) of associated with imagery and deep tissue
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.15 Pain Relevance 0.20
Cells were also labeled with a lipophilic membrane associating dye, CellVue NIR 815 (NIR815), to enable deep tissue fluorescent imaging (Fig. 1B).
NIR815 Binding (associating) of associated with imagery and deep tissue
3) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.16 Pain Relevance 0.20
Homing to the spleen was also observed through fluorescence imaging of NIR815 in both live animals and excised organs.
NIR815 Binding (imaging) of in spleen associated with imagery
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0 Pain Relevance 0.16
Thus, few restrictions may exist for biological applications of the IQ-tag/NIR fluorochrome interaction.
NIR Binding (interaction) of
5) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1919420 Disease Relevance 0 Pain Relevance 0
NIR fluorescence imaging
NIR Binding (imaging) of associated with imagery
6) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2626246 Disease Relevance 0.21 Pain Relevance 0.52
The identified IQ-tag peptide (IQSPHFF) is unique and has a sub-nanomolar binding affinity for the NIR fluorochrome GH680, due to a number of optimal binding interactions between the peptide and benzindolium dye.
NIR fluorochrome GH680 Binding (interactions) of
7) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1919420 Disease Relevance 0 Pain Relevance 0.03
Thus, the discovery of short peptides specific to organic fluorochromes through library screening may a) provide a minimally invasive way of “tagging” proteins, b) enable imaging of intracellular proteins and c) provide specificity since endogenous proteins should not recognize NIR dyes.
NIR Neg (not) Binding (recognize) of associated with imagery
8) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1919420 Disease Relevance 0 Pain Relevance 0.21
In immunocytochemistry the NOC1 and NOC2 recognized all well-established "enkephalin immunoreactive sites," but they did not bind to areas known to contain beta-endorphin or high levels of pro-enkephalin.
NOC2 Binding (recognized) of associated with enkephalin
9) Confidence 0.04 Published 1984 Journal J. Histochem. Cytochem. Section Abstract Doc Link 6086744 Disease Relevance 0.08 Pain Relevance 0.69
In immunocytochemistry the NOC1 and NOC2 recognized all well-established "enkephalin immunoreactive sites," but they did not bind to areas known to contain beta-endorphin or high levels of pro-enkephalin.
NOC2 Neg (not) Binding (bind) of associated with enkephalin
10) Confidence 0.04 Published 1984 Journal J. Histochem. Cytochem. Section Abstract Doc Link 6086744 Disease Relevance 0.08 Pain Relevance 0.70

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