INT40159

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Context Info
Confidence 0.51
First Reported 1984
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 3.51
Pain Relevance 7.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
synaptic cleft 1
brain 1
heart 1
hippocampus 1
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1057 100.00 Very High Very High Very High
nMDA receptor 48 100.00 Very High Very High Very High
Glutamate 112 99.92 Very High Very High Very High
agonist 339 99.84 Very High Very High Very High
Endep 10 99.76 Very High Very High Very High
gABA 104 99.56 Very High Very High Very High
Lasting pain 1 99.42 Very High Very High Very High
Clonidine 5 98.64 Very High Very High Very High
Dopamine 77 98.52 Very High Very High Very High
Central nervous system 95 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 8 99.88 Very High Very High Very High
Pain 10 99.42 Very High Very High Very High
Heart Rate Under Development 38 98.92 Very High Very High Very High
Hypoxia 83 98.32 Very High Very High Very High
Cv Unclassified Under Development 103 95.28 Very High Very High Very High
Ataxia 16 91.68 High High
Disease 54 89.64 High High
Dislocations 2 85.84 High High
Neuropathic Pain 1 84.76 Quite High
Drug Induced Neurotoxicity 16 73.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This dose of DPCPX was described previously to sufficiently block A1AR [17].
Negative_regulation (block) of A1AR
1) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.09 Pain Relevance 0.13
Genetic deletion of the A1AR abolishes adenosine-induced slowing of the heart-rate
Negative_regulation (abolishes) of A1AR in heart associated with adenocard
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.26 Pain Relevance 0.51
Here, the antinociceptive effect of amitriptyline, and the ability of caffeine to reverse it, were examined using the formalin test (a model of persistent pain) in wild type mice and mice lacking the adenosine A(1) receptor (A1R).
Negative_regulation (lacking) of A1R associated with pain, adenocard, lasting pain, endep and antinociceptive
3) Confidence 0.42 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18562097 Disease Relevance 0.27 Pain Relevance 1.06
All in all, these results suggest that the extent and the kinetics of agonist-induced desensitization of A1Rs depend on the subcellular localization of the receptors [40].
Negative_regulation (desensitization) of A1R associated with agonist
4) Confidence 0.42 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.15 Pain Relevance 0.26
Regarding the desensitization of A1Rs but not of Y1Rs, this may be important under pathophysiological conditions with increased adenosine concentration in the synaptic cleft.
Neg (not) Negative_regulation (desensitization) of A1R in synaptic cleft associated with adenocard
5) Confidence 0.42 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.07 Pain Relevance 0.34
However, problems arise due to long-term desensitization of A1Rs.
Negative_regulation (desensitization) of A1R
6) Confidence 0.42 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.31
The activation of hippocampal A3Rs induced a desensitization of A1Rs on combined superfusion of Cl-IB-MECA and adenosine.
Negative_regulation (desensitization) of A1R associated with adenocard
7) Confidence 0.42 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.22
The action of GABA becomes evident when A1Rs are blocked.
Negative_regulation (blocked) of A1R associated with gaba
8) Confidence 0.42 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.59 Pain Relevance 0.58
Interaction between A1Rs and NMDA receptors
Negative_regulation (receptors) of A1R associated with nmda receptor
9) Confidence 0.41 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.07 Pain Relevance 0.62
The researchers first asked whether ischemic preconditioning protects the kidneys of mice strains that lack the genes for individual adenosine receptors (A1AR?
Negative_regulation (lack) of A1AR associated with adenocard and sprains and strains
10) Confidence 0.38 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504049 Disease Relevance 1.04 Pain Relevance 0.61
These results, therefore, suggest that the clonidine-induced self-biting could be substantially attributed to adenosine A1-receptor blockade as documented for pharmacological property of theophylline in the brain.
Negative_regulation (blockade) of A1-receptor in brain associated with adenocard and clonidine
11) Confidence 0.38 Published 1984 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6087373 Disease Relevance 0 Pain Relevance 0.65
We examined if complete elimination of A1R would mimic the effect of caffeine.
Spec (examined) Negative_regulation (elimination) of A1R
12) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0 Pain Relevance 0.36
However, A1R blockade may also contribute to an increased dopamine release but this effect seems without clinical relevance.


Negative_regulation (blockade) of A1R associated with dopamine
13) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.33 Pain Relevance 0.57
A2AR activation by agonists caused A1R desensitization resulting in decreased binding affinity for CPA in the hippocampus in young adult rats.
Negative_regulation (desensitization) of A1R in hippocampus associated with agonist and hippocampus
14) Confidence 0.07 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.41
Regarding the desensitization of A1Rs during hypoxia [109, 110], it may be assumed that GABAA-mediated inhibition of the synaptic transmission is evident when the A1R is desensitized or downregulated [108].
Negative_regulation (downregulated) of A1R associated with hypoxia
15) Confidence 0.07 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.63 Pain Relevance 0.50

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