INT40160

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Context Info
Confidence 0.70
First Reported 1984
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 74
Total Number 85
Disease Relevance 26.36
Pain Relevance 33.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
neurons 12
brain 2
neuronal 2
striatum 1
motor neurons 1
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 2782 100.00 Very High Very High Very High
B1 receptor 7 100.00 Very High Very High Very High
bradykinin 6 100.00 Very High Very High Very High
antinociception 40 99.96 Very High Very High Very High
addiction 24 99.92 Very High Very High Very High
depression 643 99.84 Very High Very High Very High
agonist 833 99.76 Very High Very High Very High
Morphine 20 99.68 Very High Very High Very High
Inflammation 99 99.56 Very High Very High Very High
Antinociceptive 288 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 47 100.00 Very High Very High Very High
Heart Rate Under Development 95 99.92 Very High Very High Very High
Depression 678 99.84 Very High Very High Very High
INFLAMMATION 96 99.56 Very High Very High Very High
Disease 101 99.40 Very High Very High Very High
Targeted Disruption 62 99.24 Very High Very High Very High
Hypoxia 335 99.04 Very High Very High Very High
Diarrhoea 1 98.60 Very High Very High Very High
Neuropathic Pain 47 98.54 Very High Very High Very High
Nervous System Injury 57 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As pharmacological evidence indicates that the effect is mediated through adenosine A1 receptors (A1R), we expected A1R knockout (KO) mice to have reduced rebound sleep after SD.
Positive_regulation (mediated) of A1R associated with targeted disruption, adenocard and sleep disorders
1) Confidence 0.70 Published 2003 Journal J Sleep Res Section Abstract Doc Link 14633239 Disease Relevance 0.62 Pain Relevance 0.38
Thus, A1AR activation counteracts the effect of the ?
Positive_regulation (activation) of A1AR
2) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.29 Pain Relevance 0.23
Furthermore, activation of A1AR by adenosine causes an inhibition of adenylate cyclase, which results in decreased intracellular levels of cAMP [35].
Positive_regulation (activation) of A1AR associated with adenocard
3) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.24 Pain Relevance 0.33
Likewise, direct activation of A1R with adenosine or selective A1R agonists had antinociceptive effects in rodents and humans [13-31].
Positive_regulation (activation) of A1R associated with adenocard, agonist and antinociceptive
4) Confidence 0.68 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.69 Pain Relevance 0.89
These motor side effects are likely due to activation of A1R on motor neurons [39].
Positive_regulation (activation) of A1R in motor neurons
5) Confidence 0.68 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.18 Pain Relevance 0.48
These data suggested that spinal delivery of PAP protein could be used therapeutically to generate adenosine and activate A1R over an extended time period.
Positive_regulation (activate) of A1R in spinal associated with adenocard
6) Confidence 0.68 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.71 Pain Relevance 0.89
Our present study indicates that NT5E, an ectonucleotidase that hydrolyzes AMP to adenosine, provides an alternative means of activating A1R for therapeutic purposes without causing overt motor paralysis.
Positive_regulation (activating) of A1R associated with adenocard and paralysis
7) Confidence 0.68 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.19 Pain Relevance 0.52
In addition to the inhibitory effect on the presynaptic site, the activation of A1Rs acts as an inhibitory modulator to electrical activity on the postsynaptic site, and this effect has been attributed to enhancement of KATP activity.
Positive_regulation (activation) of A1R
8) Confidence 0.67 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.13 Pain Relevance 0.52
There is some evidence that activation of A1Rs is also involved in GABAA receptor downregulation, implying a facilitation of the neurotransmission on a postsynaptic site.
Positive_regulation (activation) of A1R
9) Confidence 0.67 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.83
In line with these results, it has been shown that the tonic activation of A1Rs by ambient adenosine depressed field potentials in the striatum.
Positive_regulation (activation) of A1R in striatum associated with adenocard
10) Confidence 0.67 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.21 Pain Relevance 0.83
The assumption that the activation of A1Rs can presynaptically modulate inhibitory postsynaptic responses agrees with findings in several brain areas, such as the thalamus [87], suprachiasmatic and arcuate nucleus [88], and substantia nigra pars compacta [86].
Positive_regulation (activation) of A1R in arcuate nucleus associated with substantia nigra and thalamus
11) Confidence 0.67 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.79
This is based on direct and indirect effects associated with the activation of cardiac A1ARs.
Positive_regulation (activation) of A1AR
12) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.28 Pain Relevance 0.39
These results are in line with other studies indicating that adenosine downregulates excitatory and inhibitory synaptic transmission in several brain areas through activation of A1Rs and A2AR [97, 98].
Positive_regulation (activation) of A1R in brain associated with adenocard
13) Confidence 0.67 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.14 Pain Relevance 0.57
Activation of A1Rs inhibits the release of GABA from the ischemic cerebral cortex in vivo [106].
Positive_regulation (Activation) of A1R in cerebral cortex associated with gaba and cerebral cortex
14) Confidence 0.67 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.41 Pain Relevance 0.80
Activation of A1Rs inhibited the activity of inspiratory neurons in the brainstem by opening KATP in neonatal mice [123].
Positive_regulation (Activation) of A1R in brainstem associated with medulla
15) Confidence 0.67 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.62
Note: an alternative hypothesis could be that A1R activation substantially increases extracellular levels of GABA and/or glycine thereby depressing the activity of postsynaptic neurons and thus depressing network activity.
Positive_regulation (activation) of A1R in neurons associated with gaba
16) Confidence 0.61 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.15 Pain Relevance 0.19
Since A1R activation is known to affect membrane properties, and in some neurons overall excitability, we examined the effects of NCPA on the Rin, INa (only without synaptic isolation) and IKd of inspiratory preBötC neurons.
Positive_regulation (activation) of A1R in neurons
17) Confidence 0.61 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0 Pain Relevance 0
Effects of A1R activation on synaptic inputs
Positive_regulation (activation) of A1R
18) Confidence 0.61 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.09 Pain Relevance 0
Since GABAAergic and glycinergic transmission affect the pattern of pre-BötC output, the effect of A1R activation on inputs via these transmitters was examined as proxy for the effects of A1R activation on fast chemical transmission in general.
Positive_regulation (activation) of A1R
19) Confidence 0.61 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.15 Pain Relevance 0.19
Thus, the data presented herein do not rule out the possibility that A1R activation may depress preBötC rhythmogenesis by directly inhibiting excitatory transmission between preBötC neurons.
Positive_regulation (activation) of A1R in neurons
20) Confidence 0.61 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.20 Pain Relevance 0.23

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