INT40170

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Context Info
Confidence 0.05
First Reported 1984
Last Reported 1993
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.12
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
pancreatic islets 2
neurons 2
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 8 100.00 Very High Very High Very High
Morphine 6 99.84 Very High Very High Very High
agonist 2 95.00 High High
Dopamine 4 92.96 High High
tolerance 1 43.44 Quite Low
addiction 1 42.88 Quite Low
Disease Link Frequency Relevance Heat
Cancer 1 61.48 Quite High
Vibrio Infection 1 59.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibitory effect of clonidine upon adenylate cyclase activity, cyclic AMP production, and insulin release in rat pancreatic islets.
Regulation (effect) of Localization (release) of cyclase in pancreatic islets associated with clonidine
1) Confidence 0.05 Published 1984 Journal Biosci. Rep. Section Title Doc Link 6087950 Disease Relevance 0.06 Pain Relevance 0.60
Adaptive changes in the number of Gs- and Gi-proteins underlie adenylyl cyclase sensitization in morphine-treated rat striatal neurons.
Regulation (underlie) of Localization (sensitization) of cyclase in neurons associated with morphine
2) Confidence 0.04 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 8386668 Disease Relevance 0.06 Pain Relevance 0.56

General Comments

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