INT40178

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Context Info
Confidence 0.44
First Reported 1983
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 0.23
Pain Relevance 6.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
brain 2
nucleus accumbens 1
PVN 1
hippocampus 1
Penk (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 97 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
opioid receptor 2 99.80 Very High Very High Very High
Nucleus accumbens 9 98.20 Very High Very High Very High
Hippocampus 5 97.56 Very High Very High Very High
Peripheral nervous system 1 96.04 Very High Very High Very High
opiate 16 94.32 High High
medulla 2 92.52 High High
Endogenous opioid 2 90.44 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 2 89.20 High High
Convulsion 1 75.76 Quite High
Epilepsy 1 65.08 Quite High
Inflammatory Pain 1 45.76 Quite Low
Targeted Disruption 1 43.32 Quite Low
Disease 8 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Supranuclear Palsy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High concentrations of ethanol were more effective at decreasing receptor affinity for both DHM and ENK when the binding assays were performed in the presence of GTP or Na+.
ENK Binding (affinity) of associated with enkephalin
1) Confidence 0.44 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6088688 Disease Relevance 0 Pain Relevance 0.68
In addition, at 37 degrees C and in the presence of GTP or Na+, DHM binding, but not ENK binding, was significantly inhibited by a low, physiologically attainable concentration of ethanol.
ENK Binding (binding) of associated with enkephalin
2) Confidence 0.44 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6088688 Disease Relevance 0 Pain Relevance 0.67
Distribution and polysome association of full-length and 3' truncated preproenkephalin mRNA in the guinea-pig brain.
preproenkephalin Binding (association) of in brain associated with enkephalin
3) Confidence 0.41 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9191091 Disease Relevance 0 Pain Relevance 0.36
Over the concentration range of 50-1,000 mM, ethanol inhibited 0.5 nM 3H-[D-Ala2,D-Leu5]enkephalin (3H-ENK) binding to mouse caudate tissue, and no stimulation of 3H-ENK binding was noted at any of these concentrations of ethanol.
ENK Binding (binding) of associated with enkephalin
4) Confidence 0.36 Published 1983 Journal Life Sci. Section Abstract Doc Link 6296588 Disease Relevance 0 Pain Relevance 0.40
Over the concentration range of 50-1,000 mM, ethanol inhibited 0.5 nM 3H-[D-Ala2,D-Leu5]enkephalin (3H-ENK) binding to mouse caudate tissue, and no stimulation of 3H-ENK binding was noted at any of these concentrations of ethanol.
ENK Binding (binding) of associated with enkephalin
5) Confidence 0.35 Published 1983 Journal Life Sci. Section Abstract Doc Link 6296588 Disease Relevance 0 Pain Relevance 0.41
In the present study, we examined the effect of the KD on the increase of PENK, Fos, Jun, AP-1 DNA-binding activity and JNK gene expression induced by KA in the mouse hippocampus.
PENK Binding (binding) of in hippocampus associated with hippocampus
6) Confidence 0.34 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.14 Pain Relevance 0.23
The binding affinity of the product, REAL-ENK, to opioid receptors was greatly reduced.
REAL-ENK Binding (affinity) of associated with opioid receptor and enkephalin
7) Confidence 0.33 Published 2006 Journal J Drug Target Section Abstract Doc Link 16753826 Disease Relevance 0 Pain Relevance 0.86
The authors demonstrate phosphorylation of the cyclic amino-3-hydroxy-5-methyl-4-isoxazolepropionate response element binding protein, a transcription factor known to interact with proenkephalin regulatory sequences within the transgene, in the PVN following LPS administration.
proenkephalin Binding (interact) of in PVN
8) Confidence 0.21 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10023810 Disease Relevance 0 Pain Relevance 0.08
[The content of dynorphin, Met-enk-Arg6-Phe7 and substance P (1-11) in the brain of mice with different levels of ethanol consumption].
Met-enk-Arg6-Phe7 Binding (content) of in brain associated with dynorphin and substance p
9) Confidence 0.20 Published 1993 Journal Biull Eksp Biol Med Section Title Doc Link 7506073 Disease Relevance 0.09 Pain Relevance 0.50
In immunohistochemistry, the antibody recognizes all well established ENK-ir sites but does not bind to areas known to contain ?
ENK Binding (recognizes) of associated with enkephalin
10) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137841 Disease Relevance 0 Pain Relevance 0.98
After this, the sections were thoroughly rinsed in PBS and incubated in the biotinylated secondary antibody solution for ENK (antimouse IgG made in horse, 1?
ENK Binding (solution) of associated with enkephalin
11) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137841 Disease Relevance 0 Pain Relevance 0.77
OTR binding displayed an overlapping distribution with substance P mRNA and preproenkephalin mRNA, both markers for the shell and core of the nucleus accumbens.
preproenkephalin mRNA Binding (binding) of in nucleus accumbens associated with nucleus accumbens and substance p
12) Confidence 0.00 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14689486 Disease Relevance 0 Pain Relevance 0.25

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