INT4020

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Context Info
Confidence 0.61
First Reported 1976
Last Reported 2005
Negated 1
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.19
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLA2G1B) extracellular space (PLA2G1B) extracellular region (PLA2G1B)
Anatomy Link Frequency
MHL 1
egg 1
PLA2G1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 2 99.86 Very High Very High Very High
Inflammation 2 96.16 Very High Very High Very High
cocaine 3 95.12 Very High Very High Very High
lidocaine 3 94.76 High High
Potency 3 92.64 High High
agonist 1 92.12 High High
cINOD 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to investigate the effect of clonidine on phospholipase A2 activity in an established in vitro model.
Spec (investigate) Regulation (effect) of phospholipase A2 associated with clonidine
1) Confidence 0.61 Published 2005 Journal Eur J Anaesthesiol Section Abstract Doc Link 16318667 Disease Relevance 0.19 Pain Relevance 0.31
We investigated the effects of phospholipase A2 (PLA2) activation and inhibition on the chemotaxis of mixed human leukocytes (MHL) in a 48-well microchemotaxis chamber and on the production of leukotriene B4 (LTB4) by an enzyme immuno assay.
Spec (investigated) Regulation (effects) of phospholipase A2 in MHL
2) Confidence 0.35 Published 1998 Journal Arzneimittelforschung Section Abstract Doc Link 9522038 Disease Relevance 0 Pain Relevance 0
Phospholipase A2 activity in crude venom of Crotalus adamanteus was not affected or slightly stimulated by local anaesthetics up to 10(-2) M concentrations, when egg yolk was used as substrate.
Neg (not) Regulation (affected) of Phospholipase A2 in egg
3) Confidence 0.04 Published 1976 Journal Biochim. Biophys. Acta Section Abstract Doc Link 952985 Disease Relevance 0 Pain Relevance 0.33

General Comments

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