INT4021

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 35
Total Number 35
Disease Relevance 23.27
Pain Relevance 8.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLA2G1B) extracellular space (PLA2G1B) extracellular region (PLA2G1B)
Anatomy Link Frequency
bladder 2
plasma 1
endothelial cells 1
exocrine glands 1
brain 1
PLA2G1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 225 100.00 Very High Very High Very High
cytokine 88 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
calcitonin gene related peptide 1 100.00 Very High Very High Very High
ischemia 6 99.90 Very High Very High Very High
Sciatica 6 99.90 Very High Very High Very High
Nicotine 9 99.56 Very High Very High Very High
Kinase C 18 99.06 Very High Very High Very High
Chronic pancreatitis 20 98.48 Very High Very High Very High
Neuritis 4 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 267 100.00 Very High Very High Very High
Cv Unclassified Under Development 1 99.90 Very High Very High Very High
Pancreatitis 70 99.80 Very High Very High Very High
Cv General 4 Under Development 9 99.68 Very High Very High Very High
Disease 45 99.40 Very High Very High Very High
Stress 41 99.04 Very High Very High Very High
Injury 15 98.80 Very High Very High Very High
Intervertebral Disk Displacement 2 98.80 Very High Very High Very High
Epilepsy 1 98.48 Very High Very High Very High
Shock 4 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum PLA2 was elevated in all six patients with acute pancreatitis.
Positive_regulation (elevated) of PLA2 associated with pancreatitis
1) Confidence 0.70 Published 1991 Journal Gastroenterol. Jpn. Section Abstract Doc Link 1706672 Disease Relevance 0.90 Pain Relevance 0.25
During EAN a marked reduction of phosphatidylinositol, sulfatides and serine-plasmalogen as well as a significant increase of phospholipase A2 activity could be observed.
Positive_regulation (increase) of phospholipase A2 associated with neuritis
2) Confidence 0.70 Published 1982 Journal Fortschr. Med. Section Abstract Doc Link 6184294 Disease Relevance 0.85 Pain Relevance 0.39
RESULTS: A massive increase in phospholipase A2 activity was measured after clonidine exposure leading to final values of 92.5 +/- 3.1 pmol mg protein(-1) min(-1) (4.5-fold higher than control values; P < or = 0.01 vs. control).
Positive_regulation (increase) of phospholipase A2
3) Confidence 0.69 Published 2005 Journal Eur J Anaesthesiol Section Body Doc Link 16318667 Disease Relevance 0 Pain Relevance 0
The diagnostic significance of serum immunoreactive pancreatic phospholipase A2 (PLA2) was studied in 119 patients with pancreatic disease, 200 with various non-pancreatic disease, and 203 healthy controls using radioimmunoassay (RIA) specific to human pancreatic PLA2.
Positive_regulation (pancreatic) of phospholipase A2 associated with pancreatitis
4) Confidence 0.50 Published 1991 Journal Gastroenterol. Jpn. Section Abstract Doc Link 1706672 Disease Relevance 0.64 Pain Relevance 0.18
The diagnostic value of serum pancreatic phospholipase A2 (PLA2) in pancreatic diseases.
Positive_regulation (pancreatic) of PLA2 associated with pancreatitis
5) Confidence 0.50 Published 1991 Journal Gastroenterol. Jpn. Section Title Doc Link 1706672 Disease Relevance 0.98 Pain Relevance 0.23
The diagnostic significance of serum immunoreactive pancreatic phospholipase A2 (PLA2) was studied in 119 patients with pancreatic disease, 200 with various non-pancreatic disease, and 203 healthy controls using radioimmunoassay (RIA) specific to human pancreatic PLA2.
Positive_regulation (pancreatic) of PLA2 associated with pancreatitis
6) Confidence 0.50 Published 1991 Journal Gastroenterol. Jpn. Section Abstract Doc Link 1706672 Disease Relevance 0.64 Pain Relevance 0.18
The diagnostic value of serum pancreatic phospholipase A2 (PLA2) in pancreatic diseases.
Positive_regulation (pancreatic) of phospholipase A2 associated with pancreatitis
7) Confidence 0.50 Published 1991 Journal Gastroenterol. Jpn. Section Title Doc Link 1706672 Disease Relevance 0.98 Pain Relevance 0.23
Samples were assayed for phospholipase A2 activity.
Positive_regulation (assayed) of phospholipase A2
8) Confidence 0.50 Published 1990 Journal Spine Section Abstract Doc Link 2218714 Disease Relevance 0.84 Pain Relevance 0.37
High levels of inflammatory phospholipase A2 activity in lumbar disc herniations.
Positive_regulation (levels) of phospholipase A2 associated with inflammation and sciatica
9) Confidence 0.47 Published 1990 Journal Spine Section Title Doc Link 2218714 Disease Relevance 0.84 Pain Relevance 0.48
Phospholipase A2 activation is the pivotal step in the effector pathway of inflammation.
Positive_regulation (activation) of Phospholipase A2 associated with inflammation and cytokine
10) Confidence 0.46 Published 1990 Journal Adv. Exp. Med. Biol. Section Title Doc Link 2239447 Disease Relevance 0.74 Pain Relevance 0.43
The identification of high levels of an inflammatory enzyme, phospholipase A2, in lumbar herniated and degenerative discs presents the basis for a direct inflammogenic capability of lumbar discs, separate from a immunologic mechanism.
Positive_regulation (levels) of phospholipase A2 associated with inflammation
11) Confidence 0.46 Published 1995 Journal Spine Section Abstract Doc Link 7502140 Disease Relevance 0.68 Pain Relevance 0.39
The diagnostic significance of serum immunoreactive pancreatic phospholipase A2 (PLA2) was studied in 119 patients with pancreatic disease, 200 with various non-pancreatic disease, and 203 healthy controls using radioimmunoassay (RIA) specific to human pancreatic PLA2.
Positive_regulation (pancreatic) of PLA2 associated with pancreatitis
12) Confidence 0.44 Published 1991 Journal Gastroenterol. Jpn. Section Abstract Doc Link 1706672 Disease Relevance 0.78 Pain Relevance 0.23
Elevated levels of circulating phospholipase A2 (PLA2) correlate with the severity of circulatory collapse and pulmonary dysfunction in gram-negative septic shock.
Positive_regulation (levels) of phospholipase A2 associated with shock and sepsis
13) Confidence 0.39 Published 1986 Journal Agents Actions Section Abstract Doc Link 3825740 Disease Relevance 0.53 Pain Relevance 0.18
Therefore, we studied: (a) the influence of nicotine and cotinine on the effects of PGE2 on placental vasculature in perfused human placental cotyledon, and (b) the activation of placental phospholipase A2 (PLA2) by nicotine and cotinine using 1-palmitoyl-2-[1-14C]arachidonyl-phosphatidylethanolamine (PE, 2.2 nmol) as substrate.
Positive_regulation (activation) of phospholipase A2 in PGE2 associated with nicotine
14) Confidence 0.36 Published 1999 Journal Pharmacology Section Abstract Doc Link 9873232 Disease Relevance 0.34 Pain Relevance 0.32
Abnormally elevated levels of serum P-PLA2 concentrations seem to reflect the inflammation of pancreas, while abnormally low levels indicate the hypofunction of pancreatic exocrine glands.
Positive_regulation (elevated) of P-PLA2 in exocrine glands associated with inflammation
15) Confidence 0.32 Published 1993 Journal Kaku Igaku Section Abstract Doc Link 8230832 Disease Relevance 0.60 Pain Relevance 0.13
All serum specimens from patients with acute pancreatitis (n = 7) were found to have elevated levels of serum P-PLA2.
Positive_regulation (elevated) of P-PLA2 associated with pancreatitis
16) Confidence 0.32 Published 1993 Journal Kaku Igaku Section Abstract Doc Link 8230832 Disease Relevance 0.59 Pain Relevance 0.13
Expression of the inducible oxidoreductase cyclooxygenase-2 and cytosolic phospholipase A2 (cPLA2) are strongly activated during cerebral ischemia and trauma, epilepsy and AD, indicating the induction of proinflammatory gene pathways as a response to brain injury.
Positive_regulation (activated) of phospholipase A2 in brain associated with epilepsy, cv general 4 under development, ischemia, injury, disease and brain injury
17) Confidence 0.24 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059791 Disease Relevance 1.41 Pain Relevance 0.25
Palmitoyl trifluormethyl ketone, an inhibitor of Ca(2+) independent phospholipase A2 (iPLA2) and a less potent inhibitor of cytosolic PLA2, dose-dependently reduced the IL-1beta induced PGE2 secretion.
Neg (independent) Positive_regulation (independent) of phospholipase A2
18) Confidence 0.22 Published 2001 Journal Exp. Gerontol. Section Abstract Doc Link 11250126 Disease Relevance 0.73 Pain Relevance 0.44
It has been evidenced that hypericin PDT leads to a rapid rise in the levels of cytosolic calcium which generates the accumulation of arachidonic acid via phospholipase A2 activation (PLA2) (Figure 5).
Positive_regulation (activation) of PLA2 associated with cancer
19) Confidence 0.21 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 1.46 Pain Relevance 0
It has been evidenced that hypericin PDT leads to a rapid rise in the levels of cytosolic calcium which generates the accumulation of arachidonic acid via phospholipase A2 activation (PLA2) (Figure 5).
Positive_regulation (activation) of phospholipase A2 associated with cancer
20) Confidence 0.21 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 1.41 Pain Relevance 0

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