INT40215

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Context Info
Confidence 0.57
First Reported 1984
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 8.39
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Fech) lyase activity (Fech)
Anatomy Link Frequency
erythrocytes 2
liver 1
skin 1
Fech (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 6 97.20 Very High Very High Very High
Dismenorea 2 94.96 High High
Bile 22 94.80 High High
peripheral neuropathy 4 93.16 High High
anesthesia 2 92.96 High High
Peripheral nervous system 2 87.20 High High
Sciatic nerve 2 85.04 High High
isoflurane 5 78.00 Quite High
fibrosis 11 71.92 Quite High
alcohol 3 9.24 Low Low
Disease Link Frequency Relevance Heat
Acute Intermittent Porphyria 9 99.84 Very High Very High Very High
Erythropoietic Protoporphyria 34 99.64 Very High Very High Very High
Porphyria 10 99.62 Very High Very High Very High
Hypochromic Anemia 4 99.20 Very High Very High Very High
Anaemia 11 97.24 Very High Very High Very High
Hemolysis 2 96.76 Very High Very High Very High
Sunburn 6 96.68 Very High Very High Very High
Hyperplasia 2 95.64 Very High Very High Very High
Congenital Anomalies 5 95.52 Very High Very High Very High
Dysmenorrhea 2 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the best EPP animal model is an ethylnitrosourea-induced point mutation with fully recessive transmission, named ferrochelatase deficiency (Fech(m1Pas)).
Negative_regulation (deficiency) of ferrochelatase associated with erythropoietic protoporphyria
1) Confidence 0.57 Published 2006 Journal Physiol Res Section Abstract Doc Link 17298226 Disease Relevance 1.06 Pain Relevance 0.33
Erythropoietic protoporphyria (EPP) is an inherited disorder of heme biosynthesis caused by partial ferrochelatase deficiency, resulting in protoporphyrin overproduction which is responsible for painful skin photosensitivity.
Spec (partial) Negative_regulation (deficiency) of ferrochelatase in skin associated with pain, porphyria, sunburn and erythropoietic protoporphyria
2) Confidence 0.57 Published 2006 Journal Physiol Res Section Abstract Doc Link 17298226 Disease Relevance 1.00 Pain Relevance 0.25
FECH deficiency induced microcytic hypochromic anemia without ringed sideroblasts, little or no hemolysis, and no erythroid hyperplasia.
Negative_regulation (deficiency) of FECH associated with hemolysis, hypochromic anemia and hyperplasia
3) Confidence 0.42 Published 2007 Journal Blood Section Abstract Doc Link 17003376 Disease Relevance 0.81 Pain Relevance 0.09
However, the best EPP animal model is an ethylnitrosourea-induced point mutation with fully recessive transmission, named ferrochelatase deficiency (Fech(m1Pas)).
Negative_regulation (deficiency) of Fech associated with erythropoietic protoporphyria
4) Confidence 0.37 Published 2006 Journal Physiol Res Section Abstract Doc Link 17298226 Disease Relevance 1.05 Pain Relevance 0.32
Erythropoietic protoporphyria is an inherited disorder of heme biosynthesis caused by partial ferrochelatase deficiency, resulting in protoporphyrin (PP) overproduction by erythrocytes.
Spec (partial) Negative_regulation (deficiency) of ferrochelatase in erythrocytes associated with porphyria and erythropoietic protoporphyria
5) Confidence 0.35 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15677551 Disease Relevance 1.05 Pain Relevance 0.09
Patients with deficiency in ferrochelatase (FECH), the last enzyme of the heme biosynthetic pathway, experience a painful type of skin photosensitivity called erythropoietic protoporphyria (EPP), which is caused by the excessive production of protoporphyrin IX (PPIX) by erythrocytes.
Negative_regulation (deficiency) of ferrochelatase in erythrocytes associated with pain, sunburn and erythropoietic protoporphyria
6) Confidence 0.31 Published 2007 Journal Blood Section Abstract Doc Link 17003376 Disease Relevance 0.60 Pain Relevance 0.10
Farant and Wigfield[16] reported that inhibition of ALAD, a cytosolic sulfydryl enzyme and ferrochelatase by lead resulted in depressed heme synthesis that ultimately led to anemia.
Negative_regulation (inhibition) of ferrochelatase associated with anaemia
7) Confidence 0.21 Published 2010 Journal Toxicology International Section Body Doc Link PMC2964740 Disease Relevance 0.65 Pain Relevance 0
Erythropoietic Protoporphyria (EPP) is an inherited deficiency of ferrochelatase, the last enzyme of the heme pathway.
Negative_regulation (deficiency) of ferrochelatase associated with erythropoietic protoporphyria
8) Confidence 0.21 Published 2009 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 19268000 Disease Relevance 0.57 Pain Relevance 0.20
N-methylprotoporphyrin subsequently acts as a potent inhibitor of ferrochelatase, thereby causing porphyria (Tephly et al. 1980).
Negative_regulation (inhibitor) of ferrochelatase associated with porphyria
9) Confidence 0.12 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.27 Pain Relevance 0
An autopsy case of acute porphyria with a decrease of both uroporphyrinogen I synthetase and ferrochelatase activities.
Negative_regulation (decrease) of ferrochelatase associated with acute intermittent porphyria
10) Confidence 0.05 Published 1984 Journal Acta Neuropathol. Section Title Doc Link 6089495 Disease Relevance 0.64 Pain Relevance 0.25
In the analysis of the enzymatic activities of the liver and bone narrow, the activity of ALA synthetase (ALA-S) was markedly increased, and the activities of both uroporphyrinogen I synthetase (URO-S) and ferrochelatase were decreased.
Negative_regulation (decreased) of ferrochelatase in liver
11) Confidence 0.03 Published 1984 Journal Acta Neuropathol. Section Abstract Doc Link 6089495 Disease Relevance 0.70 Pain Relevance 0.22

General Comments

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