INT40216

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Context Info
Confidence 0.65
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 6.08
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Alas1) nucleolus (Alas1) biosynthetic process (Alas1)
nucleus (Alas1) transferase activity, transferring acyl groups (Alas1) cytoplasm (Alas1)
Anatomy Link Frequency
liver 3
hepatocytes 1
sciatic nerve 1
body 1
Alas1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
isoflurane 10 99.98 Very High Very High Very High
Sciatic nerve 3 99.78 Very High Very High Very High
alcohol 1 93.88 High High
Clonidine 5 92.64 High High
Central nervous system 1 89.56 High High
Potency 1 89.16 High High
peripheral neuropathy 6 85.96 High High
abdominal pain 1 85.24 High High
Peripheral nervous system 3 80.72 Quite High
Dismenorea 3 72.56 Quite High
Disease Link Frequency Relevance Heat
Porphyria 25 99.74 Very High Very High Very High
Stress 13 98.20 Very High Very High Very High
Erythropoietic Protoporphyria 10 97.56 Very High Very High Very High
Variegate Porphyria 45 97.24 Very High Very High Very High
Infection 1 96.80 Very High Very High Very High
Overnutrition 1 96.32 Very High Very High Very High
Acute Intermittent Porphyria 16 96.04 Very High Very High Very High
Hepatic Porphyrias 4 95.36 Very High Very High Very High
Congenital Anomalies 6 94.32 High High
Fever 1 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of rats with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) or allyl-isopropyl-acetamide (AIA) induces hepatic delta-aminolaevulinic acid synthase (ALA-S) and increases the urinary excretion of porphyrin precursors (ALA and PBG) comparable to the latent phase of acute hepatic porphyrias in humans.
Positive_regulation (induces) of ALA-S associated with porphyria and hepatic porphyrias
1) Confidence 0.65 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9239451 Disease Relevance 0.60 Pain Relevance 0.43
ALA synthase (ALA-S) induction occurred after enhancement of HO, reaching a maximum at 18 h (three-fold the control).
Positive_regulation (induction) of ALA-S
2) Confidence 0.54 Published 2000 Journal Int. J. Biochem. Cell Biol. Section Body Doc Link 11084378 Disease Relevance 0.06 Pain Relevance 0
CONCLUSION: This study shows that oxidative stress produced by APAP leads to increase in ALA-S and HO activities, indicating that toxic doses of APAP affect both heme biosynthesis and degradation.


Positive_regulation (increase) of ALA-S
3) Confidence 0.47 Published 2000 Journal Int. J. Biochem. Cell Biol. Section Body Doc Link 11084378 Disease Relevance 0 Pain Relevance 0
Administration of bilirubin (5 micromol kg(-1) body weight) or S-adenosyl L-methionine (46 micromol kg(-1) body weight) 2 h before APAP treatment entirely prevented the increase in malondialdehyde (MDA) content, the decrease in GSH levels as well as HO and ALA-S induction.
Positive_regulation (induction) of ALA-S in body
4) Confidence 0.31 Published 2000 Journal Int. J. Biochem. Cell Biol. Section Body Doc Link 11084378 Disease Relevance 0 Pain Relevance 0
This enzyme catalyses the reaction between glycine and succinyl CoA to form 5-aminolevulinate, in the first committed step in heme biosynthesis [22] and PB induces ALAS in isolated hepatocytes [23].
Positive_regulation (induces) of ALAS in hepatocytes associated with porphyria
5) Confidence 0.26 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.25 Pain Relevance 0
Biochemical analysis of the sciatic nerve showed an increase of ALA-S activity and a decrease of both URO-S and ALA dehydrase activities.
Positive_regulation (increase) of ALA-S in sciatic nerve associated with sciatic nerve
6) Confidence 0.12 Published 1984 Journal Acta Neuropathol. Section Abstract Doc Link 6089495 Disease Relevance 0.69 Pain Relevance 0.21
In the analysis of the enzymatic activities of the liver and bone narrow, the activity of ALA synthetase (ALA-S) was markedly increased, and the activities of both uroporphyrinogen I synthetase (URO-S) and ferrochelatase were decreased.
Positive_regulation (increased) of ALA-S in liver
7) Confidence 0.12 Published 1984 Journal Acta Neuropathol. Section Abstract Doc Link 6089495 Disease Relevance 0.68 Pain Relevance 0.23
In the analysis of the enzymatic activities of the liver and bone narrow, the activity of ALA synthetase (ALA-S) was markedly increased, and the activities of both uroporphyrinogen I synthetase (URO-S) and ferrochelatase were decreased.
Positive_regulation (increased) of ALA synthetase in liver
8) Confidence 0.12 Published 1984 Journal Acta Neuropathol. Section Abstract Doc Link 6089495 Disease Relevance 0.68 Pain Relevance 0.23
Fechm1Pas/Fechm1Pas mice receiving anaesthesia show enhanced ALA-S and CYP2E1 activities in the liver and increased urinary excretion of porphyrin precursors.
Positive_regulation (enhanced) of ALA-S in liver
9) Confidence 0.07 Published 2009 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 19268000 Disease Relevance 0.76 Pain Relevance 0.26
In conclusion, Isoflurane induces ALA-S activity and increased excretion of porphyrin precursors in EPP mice.
Positive_regulation (induces) of ALA-S associated with erythropoietic protoporphyria and isoflurane
10) Confidence 0.06 Published 2009 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 19268000 Disease Relevance 0.74 Pain Relevance 0.26
-aminolevulinic acid synthase (ALA-S) induction thereby increasing the production of the porphyrin precursors ALA and porphobilinogen (PBG) [3-5].
Positive_regulation (induction) of ALA-S associated with porphyria
11) Confidence 0.02 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2467414 Disease Relevance 1.61 Pain Relevance 0.18

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