INT4022

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 30
Total Number 30
Disease Relevance 10.41
Pain Relevance 7.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLA2G1B) extracellular space (PLA2G1B) extracellular region (PLA2G1B)
Anatomy Link Frequency
pancreas 2
PMNs 2
plasma 1
leukocytes 1
uterine 1
PLA2G1B (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 30 99.84 Very High Very High Very High
Inflammation 193 99.82 Very High Very High Very High
Neuritis 4 99.80 Very High Very High Very High
antagonist 3 99.34 Very High Very High Very High
lidocaine 18 99.22 Very High Very High Very High
Pain 20 99.08 Very High Very High Very High
corticosteroid 54 98.56 Very High Very High Very High
Dismenorea 2 98.48 Very High Very High Very High
cINOD 109 98.44 Very High Very High Very High
diclofenac 66 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sepsis 5 99.84 Very High Very High Very High
INFLAMMATION 212 99.82 Very High Very High Very High
Experimental Autoimmune Neuritis 4 99.80 Very High Very High Very High
Dysmenorrhea 2 98.48 Very High Very High Very High
Uterine Fibroids 144 97.80 Very High Very High Very High
Neurogenic Inflammation 6 96.24 Very High Very High Very High
Nicotine Addiction 6 96.16 Very High Very High Very High
Shock 5 95.68 Very High Very High Very High
Rhinitis 104 95.60 Very High Very High Very High
Asthma 113 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The leukotriene (LT) antagonist FPL 55712, dexamethasone, which inhibits phospholipase A2, and the antiasthmatic drug cromolyn all reduced the sustained phase significantly.
Negative_regulation (inhibits) of phospholipase A2 associated with antagonist and dexamethasone
1) Confidence 0.59 Published 1987 Journal J. Appl. Physiol. Section Abstract Doc Link 3121570 Disease Relevance 0 Pain Relevance 0.41
CONCLUSION: We conclude that the putative anti-inflammatory effect of clonidine was not caused by inhibition of phospholipase A2.


Negative_regulation (inhibition) of phospholipase A2
2) Confidence 0.58 Published 2005 Journal Eur J Anaesthesiol Section Body Doc Link 16318667 Disease Relevance 0 Pain Relevance 0
Moreover, inhibitors of phospholipase A2 prevented stimulation of oscillatory uterine contractions by the commercial PCB mixture Aroclor 1242, suggesting involvement of arachidonic acid in the Aroclor 1242-induced stimulation.
Negative_regulation (inhibitors) of phospholipase A2 in uterine associated with dismenorea
3) Confidence 0.51 Published 2002 Journal Int J Hyg Environ Health Section Abstract Doc Link 12018005 Disease Relevance 0.17 Pain Relevance 0.17
We suggest that PAMBA reduces the accumulation of bronchoconstrictory metabolites of arachidonic acid via inhibition of phospholipase A2.
Negative_regulation (inhibition) of phospholipase A2
4) Confidence 0.49 Published 1986 Journal Eur J Respir Dis Section Abstract Doc Link 3485054 Disease Relevance 0.42 Pain Relevance 0.17
In contrast, the non-steroidal anti-inflammatory drugs (indomethacin, meclofenamic acid and aspirin), which only block the cyclo-oxygenase pathway of AA metabolism, had little effect on enzyme release from PMNs induced by the same stimuli. 5,8,11-Eicosatriynoic acid (ETI), a selective inhibitor of the lipoxygenase pathway of AA metabolism, caused a dose-dependent inhibition of lysosomal enzyme release elicited by Zx, f-met peptide, and A23187. p-Bromophenacyl bromide (BPB), which inhibits the phospholipase A2 (PLA2) activity in several tissues, was found to cause a dose-dependent inhibition of lysosomal enzyme release induced by the same immunological and non-immunological stimuli.
Negative_regulation (inhibits) of phospholipase A2 in PMNs associated with aspirin, inflammation and cinod
5) Confidence 0.46 Published 1983 Journal J Clin Lab Immunol Section Abstract Doc Link 6644791 Disease Relevance 0.09 Pain Relevance 0.14
During EAN a marked reduction of phosphatidylinositol, sulfatides and serine-plasmalogen as well as a significant increase of phospholipase A2 activity could be observed.
Negative_regulation (reduction) of phospholipase A2 associated with neuritis
6) Confidence 0.43 Published 1982 Journal Fortschr. Med. Section Abstract Doc Link 6184294 Disease Relevance 0.89 Pain Relevance 0.41
The purpose of the present study was to find out whether lidocaine, a well known membrane stabilizer and PLA2 (phospholipase A2) inhibitor could be applied in pancreas preservation for protection of endo- and exocrine pancreatic tissue from cells damage which occurs during and after storage.
Negative_regulation (inhibitor) of phospholipase A2 in pancreas associated with lidocaine
7) Confidence 0.43 Published 2000 Journal Acta Pol Pharm Section Abstract Doc Link 11243252 Disease Relevance 0.32 Pain Relevance 0.46
The purpose of the present study was to find out whether lidocaine, a well known membrane stabilizer and PLA2 (phospholipase A2) inhibitor could be applied in pancreas preservation for protection of endo- and exocrine pancreatic tissue from cells damage which occurs during and after storage.
Negative_regulation (inhibitor) of PLA2 in pancreas associated with lidocaine
8) Confidence 0.43 Published 2000 Journal Acta Pol Pharm Section Abstract Doc Link 11243252 Disease Relevance 0.32 Pain Relevance 0.46
Arachidonic acid is liberated from membrane phospholipids by phospholipase A2, an enzyme that can be blocked by glucocorticoids.
Negative_regulation (blocked) of phospholipase A2
9) Confidence 0.43 Published 1993 Journal Agents Actions Section Abstract Doc Link 8317318 Disease Relevance 0.43 Pain Relevance 0.72
Potential therapeutic efficacy of inhibitors of human phospholipase A2 in septic shock.
Negative_regulation (inhibitors) of phospholipase A2 associated with sepsis
10) Confidence 0.43 Published 1986 Journal Agents Actions Section Title Doc Link 3825740 Disease Relevance 0.54 Pain Relevance 0.26
Functional inhibitors of phospholipase A2 (PLA2), such as dexamethasone and quinacrine, do not mimick the effects of NSAID.
Negative_regulation (inhibitors) of phospholipase A2 associated with cinod and dexamethasone
11) Confidence 0.39 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10364464 Disease Relevance 0.33 Pain Relevance 1.06
Investigation on the effect of experimental phospholipase A2 inhibitors on the formyl-methionyl-leucyl-phenylalanine-stimulated chemotaxis of human leukocytes in vitro.
Negative_regulation (inhibitors) of phospholipase A2 in leukocytes
12) Confidence 0.33 Published 1998 Journal Arzneimittelforschung Section Title Doc Link 9522038 Disease Relevance 0 Pain Relevance 0
Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2.
Negative_regulation (inhibition) of phospholipase A2 associated with inflammation
13) Confidence 0.32 Published 2007 Journal J. Med. Chem. Section Title Doc Link 17672443 Disease Relevance 0 Pain Relevance 0.31
Protein-based alignment in 3D QSAR of 26 indole inhibitors of human pancreatic phospholipase A2.
Negative_regulation (inhibitors) of phospholipase A2
14) Confidence 0.29 Published 2001 Journal Eur J Med Chem Section Title Doc Link 11231046 Disease Relevance 0.07 Pain Relevance 0.11
An automated docking procedure was applied on a series of 26 reversible and competitive indole inhibitors of human pancreatic phospholipase A2 (hp-PLA2).
Negative_regulation (inhibitors) of phospholipase A2
15) Confidence 0.29 Published 2001 Journal Eur J Med Chem Section Abstract Doc Link 11231046 Disease Relevance 0.06 Pain Relevance 0.08
Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2.
Negative_regulation (inhibition) of phospholipase A2 associated with inflammation
16) Confidence 0.28 Published 2007 Journal J. Med. Chem. Section Title Doc Link 17672443 Disease Relevance 0 Pain Relevance 0.30
Palmitoyl trifluormethyl ketone, an inhibitor of Ca(2+) independent phospholipase A2 (iPLA2) and a less potent inhibitor of cytosolic PLA2, dose-dependently reduced the IL-1beta induced PGE2 secretion.
Negative_regulation (inhibitor) of phospholipase A2
17) Confidence 0.26 Published 2001 Journal Exp. Gerontol. Section Abstract Doc Link 11250126 Disease Relevance 0.73 Pain Relevance 0.44
The study indicates that benzydamine reduces the prostaglandin synthesis in gingival fibroblasts, partly at the level of phospholipase A2, by diminishing the liberation of arachidonic acid (AA) from phospholipids, and partly at the level of cyclooxygenase.
Negative_regulation (reduces) of phospholipase A2 in fibroblasts
18) Confidence 0.25 Published 1999 Journal Acta Odontol. Scand. Section Abstract Doc Link 10207535 Disease Relevance 0.21 Pain Relevance 0.25
SB 203347, an inhibitor of 14 kDa phospholipase A2, alters human neutrophil arachidonic acid release and metabolism and prolongs survival in murine endotoxin shock.
Negative_regulation (inhibitor) of phospholipase A2 in neutrophil associated with shock
19) Confidence 0.21 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7562496 Disease Relevance 0.26 Pain Relevance 0.15
This anti-inflammatory protein can inhibit enzymes phospholipase A2 and COX-2, thereby inhibiting prostaglandin synthesis [31].
Negative_regulation (inhibit) of phospholipase A2 associated with inflammation
20) Confidence 0.19 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 0.59 Pain Relevance 0.47

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