INT4029

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Context Info
Confidence 0.69
First Reported 1976
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 2.00
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (HYAL1) hydrolase activity, acting on glycosyl bonds (HYAL1) cell death (HYAL1)
extracellular region (HYAL1) carbohydrate metabolic process (HYAL1) lysosome (HYAL1)
Anatomy Link Frequency
plasma 3
connective tissues 1
HYAL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 6 98.52 Very High Very High Very High
Inflammation 45 97.20 Very High Very High Very High
Morphine 14 96.08 Very High Very High Very High
lidocaine 2 90.92 High High
Enkephalin 3 85.48 High High
Pain 2 78.68 Quite High
sodium channel 1 77.64 Quite High
cytokine 32 60.08 Quite High
palliative 1 55.36 Quite High
alcohol 3 52.88 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 6 98.52 Very High Very High Very High
Pheochromocytoma 1 98.36 Very High Very High Very High
INFLAMMATION 49 97.20 Very High Very High Very High
Anaemia 1 93.24 High High
Toxicity 2 92.20 High High
Injury 22 90.24 High High
Disease 32 89.28 High High
Volume Depletion And Dehydration 1 89.12 High High
Myoclonus 1 87.80 High High
Delirium 1 87.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No increase in serum hyaluronidase activity was found in patients with rheumatoid arthritis.
Neg (No) Positive_regulation (increase) of hyaluronidase associated with rheumatoid arthritis
1) Confidence 0.69 Published 1976 Journal Clin. Biochem. Section Abstract Doc Link 954180 Disease Relevance 0.10 Pain Relevance 0.09
Hyaluronidase temporarily increases the permeability of SC connective tissues by degrading hyaluronan and has been shown to increase the dispersion and absorption of coadministered molecules.
Positive_regulation (increases) of Hyaluronidase in connective tissues
2) Confidence 0.44 Published 2009 Journal J Pain Symptom Manage Section Abstract Doc Link 19819665 Disease Relevance 0 Pain Relevance 0.56
In addition to use for hydration, 6 patients received recombinant human hyaluronidase to enhance subcutaneous infusion of 9 medications, primarily because the medication dosage required subcutaneous flow rates greater than the standard 3 mL/hr.
Positive_regulation (received) of hyaluronidase
3) Confidence 0.44 Published 2007 Journal J Palliat Med Section Abstract Doc Link 17803404 Disease Relevance 0.26 Pain Relevance 0.08
There was a significant increase in plasma MELS and its urinary output in patients with pheochromocytoma.
Positive_regulation (increase) of plasma MELS in plasma associated with pheochromocytoma
4) Confidence 0.39 Published 1985 Journal Endocrinol. Jpn. Section Abstract Doc Link 4085413 Disease Relevance 0.53 Pain Relevance 0.24
On the other hand, the hyaluronidase activity was stronger in specimens eluted with the gentle buffer (Fig. 5a, lane 1, and 5b, lane 2) than in specimens eluted with the glycine buffer (Fig. 5a, lane 3, and 5b, lane 4), an observation suggesting that the glycine buffer is likely to be harmful to the hyaluronidase activity of the eluted proteins.
Positive_regulation (harmful) of hyaluronidase
5) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0 Pain Relevance 0
On the other hand, the hyaluronidase activity was stronger in specimens eluted with the gentle buffer (Fig. 5a, lane 1, and 5b, lane 2) than in specimens eluted with the glycine buffer (Fig. 5a, lane 3, and 5b, lane 4), an observation suggesting that the glycine buffer is likely to be harmful to the hyaluronidase activity of the eluted proteins.
Positive_regulation (stronger) of hyaluronidase
6) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0 Pain Relevance 0
We were unable to detect any hyaluronidase activity (Fig. 5c) in the HA oligosaccharide preparation (lane 1) or the gentle buffer (lane 2).
Neg (unable) Positive_regulation (detect) of hyaluronidase
7) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0 Pain Relevance 0
Further, upon stimulation with IL-1, the amounts of the neutral-active hyaluronidase increased in both cell layers and culture media.
Positive_regulation (increased) of neutral-active hyaluronidase
8) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175024 Disease Relevance 0.05 Pain Relevance 0.06
The second objective was to determine whether elevated plasma aminotransferase levels were observed subsequent to large-volume liposuction.
Spec (whether) Positive_regulation (elevated) of plasma aminotransferase in plasma
9) Confidence 0.03 Published 2004 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 15318060 Disease Relevance 0.23 Pain Relevance 0.09
Enzyme analysis revealed low activity (2.59, 1.62, and 2.55 nmol/h/mg protein, respectively); plasma chitotriosidase levels were also elevated.
Positive_regulation (elevated) of plasma chitotriosidase in plasma
10) Confidence 0.01 Published 2009 Journal Prilozi Section Abstract Doc Link 19736544 Disease Relevance 0.25 Pain Relevance 0.08
Procyanidins was also proved to be able to inhibit the activation of hyaluronidase, a proteoglycan splitting enzyme that attacks various tissues during inflammation.
Positive_regulation (activation) of hyaluronidase associated with inflammation
11) Confidence 0.01 Published 2009 Journal Phytochem Rev Section Body Doc Link PMC2928446 Disease Relevance 0.50 Pain Relevance 0.20

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