INT403

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Context Info
Confidence 0.81
First Reported 1975
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 241
Total Number 249
Disease Relevance 28.55
Pain Relevance 81.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
pituitary 10
stomach 8
caecum 8
brain 8
thyroid 6
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 409 100.00 Very High Very High Very High
substance P 299 100.00 Very High Very High Very High
Glutamate 204 100.00 Very High Very High Very High
Enkephalin 148 100.00 Very High Very High Very High
Opioid 139 100.00 Very High Very High Very High
Somatostatin 113 100.00 Very High Very High Very High
Serotonin 100 100.00 Very High Very High Very High
narcan 98 100.00 Very High Very High Very High
Neuropeptide 94 100.00 Very High Very High Very High
Central nervous system 46 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 131 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 20 99.92 Very High Very High Very High
Starvation 138 99.80 Very High Very High Very High
Cluster Headache 4 99.80 Very High Very High Very High
Shock 27 99.72 Very High Very High Very High
Lung Cancer 48 99.60 Very High Very High Very High
Hemorrhagic Shock 2 99.60 Very High Very High Very High
Stress 663 99.54 Very High Very High Very High
Reprotox - General 1 24 99.36 Very High Very High Very High
Galactorrhea 44 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systemic capsaicin pretreatment (125 mg/kg sc) reduced the antisecretory effects of luminal acid on both TRH analogue- and pentagastrin-stimulated acid secretion.
Localization (secretion) of TRH associated with qutenza
1) Confidence 0.81 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7864125 Disease Relevance 0 Pain Relevance 0.60
Neither selective perivagal nor selective periceliac capsaicin treatments (1% solution) modified the antisecretory effect of intestinal perfusion with HCl (75 mM) on TRH analogue-stimulated acid secretion.
Localization (secretion) of TRH associated with qutenza
2) Confidence 0.81 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7864125 Disease Relevance 0 Pain Relevance 0.63
It has also been suggested that TRH localized in the pineal gland has a part in activating the neuronal mechanisms of arousal.
Localization (localized) of TRH in pineal gland
3) Confidence 0.81 Published 1990 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 2127684 Disease Relevance 0.53 Pain Relevance 0.35
In vitro cocaine (10(-6)-10(-4) M) inhibited the K(+)-stimulated release in a concentration-dependent manner, but had no effect on the basal release of TRH from the striatum and nucleus accumbens of naive rats.
Localization (release) of TRH in nucleus accumbens associated with nucleus accumbens and cocaine
4) Confidence 0.81 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9243522 Disease Relevance 0.14 Pain Relevance 0.63
Opiate inhibition of K+-induced TRH release from superfused mediobasal hypothalami in rats.
Localization (release) of TRH associated with opiate
5) Confidence 0.81 Published 1983 Journal Neuroendocrinology Section Title Doc Link 6412152 Disease Relevance 0 Pain Relevance 0.88
The effect of morphine and leucine enkephalin on basal and K+-induced TRH release by superfused mediobasal hypothalami in rats was investigated in an oxygenated modified Locke medium at 37 degrees C during 10 min.
Localization (release) of TRH associated with enkephalin and morphine
6) Confidence 0.81 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6412152 Disease Relevance 0 Pain Relevance 0.76
Both opiates (morphine, 10(-6) M; leucine enkephalin, 10(-6) M) did not modify the spontaneous release of TRH, but significantly decreased the depolarization-induced TRH release.
Localization (release) of TRH associated with enkephalin, opiate and morphine
7) Confidence 0.81 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6412152 Disease Relevance 0 Pain Relevance 0.84
These changes may be centrally mediated by TRH, which is released in association with the thermogenic response to hypothermia.
Localization (released) of TRH associated with hypothermia
8) Confidence 0.81 Published 1991 Journal Dig. Dis. Sci. Section Abstract Doc Link 1672516 Disease Relevance 0.43 Pain Relevance 0.08
The effect of morphine perfusion into the median eminence on cold-induced TRH secretion was studied in unanesthetized rats by push-pull cannulation.
Localization (secretion) of TRH in median eminence associated with morphine
9) Confidence 0.81 Published 1986 Journal Life Sci. Section Abstract Doc Link 3079851 Disease Relevance 0 Pain Relevance 0.55
Effects of morphine on cold-induced TRH release from the median eminence of unanesthetized rats.
Localization (release) of TRH in median eminence associated with narcan and morphine
10) Confidence 0.81 Published 1986 Journal Life Sci. Section Title Doc Link 3079851 Disease Relevance 0 Pain Relevance 0.66
The effect of endogenous opioid peptides (beta-endorphin, leucine-enkephalin, dynorphin 1-13 on the release of thyrotropin releasing hormone (TRH) from the rat stomach in vitro was studied.
Localization (release) of thyrotropin releasing hormone in stomach associated with dynorphin, endogenous opioid and enkephalin
11) Confidence 0.81 Published 1989 Journal Endocrinol. Exp. Section Abstract Doc Link 2565806 Disease Relevance 0 Pain Relevance 0.58
However, the inhibitory effect of endogenous opioid peptides on TRH release from the rat stomach was prevented by the addition of naloxone.
Localization (release) of TRH in stomach associated with narcan and endogenous opioid
12) Confidence 0.81 Published 1989 Journal Endocrinol. Exp. Section Abstract Doc Link 2565806 Disease Relevance 0 Pain Relevance 0.66
The release of TRH from the rat stomach was inhibited significantly in a dose-related manner with the addition of endogenous opioid peptides, but not affected with naloxone.
Localization (release) of TRH in stomach associated with narcan and endogenous opioid
13) Confidence 0.81 Published 1989 Journal Endocrinol. Exp. Section Abstract Doc Link 2565806 Disease Relevance 0 Pain Relevance 0.63
The rat stomach was incubated in the medium 199 with 1.0 mg/ml of bacitracin (pH 7.4) (medium) and the amount of TRH released into the medium was measured by radioimmunoassay.
Localization (released) of TRH in stomach
14) Confidence 0.81 Published 1989 Journal Endocrinol. Exp. Section Abstract Doc Link 2565806 Disease Relevance 0 Pain Relevance 0.61
These findings suggest that endogenous opioid peptides inhibit TRH release from the rat stomach in vitro.
Localization (release) of TRH in stomach associated with endogenous opioid
15) Confidence 0.81 Published 1989 Journal Endocrinol. Exp. Section Abstract Doc Link 2565806 Disease Relevance 0 Pain Relevance 0.64
The effect of endogenous opioid peptides (beta-endorphin, leucine-enkephalin, dynorphin 1-13 on the release of thyrotropin releasing hormone (TRH) from the rat stomach in vitro was studied.
Localization (release) of TRH in stomach associated with dynorphin, endogenous opioid and enkephalin
16) Confidence 0.81 Published 1989 Journal Endocrinol. Exp. Section Abstract Doc Link 2565806 Disease Relevance 0 Pain Relevance 0.58
Effect of endogenous opioid peptides on TRH release from rat stomach in vitro.
Localization (release) of TRH in stomach associated with narcan and endogenous opioid
17) Confidence 0.81 Published 1989 Journal Endocrinol. Exp. Section Title Doc Link 2565806 Disease Relevance 0 Pain Relevance 0.69
Thus, as the encoding and synthesis of the peptide happens fully within the striatum, it seems likely that the effects of TRH in response to LIDs did not rely on the regulation of peripheral thyroid hormones, which would require release of TRH into the portal system.
Localization (release) of TRH in thyroid associated with dyskinesias
18) Confidence 0.81 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.88 Pain Relevance 0.13
In turn, striatal dopamine levels have also been shown to modulate the release of TRH within the rat striatum [61], [62], with higher levels of dopamine correlating with higher levels of intrastriatal TRH.
Localization (release) of TRH in striatum associated with dopamine
19) Confidence 0.81 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.51 Pain Relevance 0.24
The influence of depolarizing agents on the release of TRH and histidyl-proline diketopiperazine [C(HP)] from rat hypothalami was examined in vitro.
Localization (release) of TRH
20) Confidence 0.81 Published 1987 Journal Endocrinology Section Abstract Doc Link 3100287 Disease Relevance 0 Pain Relevance 0

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