INT4030

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1976
Last Reported 1994
Negated 1
Speculated 2
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 0.96
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
capsules 2
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 46 100.00 Very High Very High Very High
opiate 32 100.00 Very High Very High Very High
Catecholamine 2 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
Morphine 6 99.66 Very High Very High Very High
agonist 1 96.68 Very High Very High Very High
Dopamine 9 95.60 Very High Very High Very High
Opioid 3 83.28 Quite High
Enkephalin 1 81.12 Quite High
anesthesia 1 81.00 Quite High
Disease Link Frequency Relevance Heat
Galactorrhea 8 99.90 Very High Very High Very High
Hemorrhage 3 97.00 Very High Very High Very High
Hypersensitivity 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis of these results, it appears that the phenomenon of opiate-induced enhancement of the effects of naloxone on serum LH levels is opiate specific and, most importantly, is a unique feature of mu opiate agonists.
Positive_regulation (enhancement) of Regulation (effects) of LH associated with agonist, narcan and opiate
1) Confidence 0.50 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6310081 Disease Relevance 0 Pain Relevance 1.38
At the age of 20 days, Oe-P did not induce any significant change of LH levels, whereas naloxone increased the serum LH concentration.
Neg (not) Positive_regulation (induce) of Regulation (change) of LH associated with narcan
2) Confidence 0.50 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3035852 Disease Relevance 0 Pain Relevance 0.40
The effects of the catecholamines on LH output were significant increases in plasma LH levels for all NE doses tested (5 mug, p less than .025; 15 mug, p less than .05; 20 mug, p less than .005), while DA had no effect.
Positive_regulation (increases) of Regulation (effects) of LH in plasma associated with dopamine and catecholamine
3) Confidence 0.49 Published 1976 Journal Endocrinology Section Abstract Doc Link 954641 Disease Relevance 0 Pain Relevance 0.37
We have examined the mode of morphine's (M) action to increase the sensitivity of castrated male rats to the inhibitory feedback action of testosterone (T) on LH release.
Spec (examined) Positive_regulation (increase) of Regulation (sensitivity) of LH associated with morphine
4) Confidence 0.47 Published 1988 Journal Endocrinology Section Abstract Doc Link 3277841 Disease Relevance 0.07 Pain Relevance 0.17
Naloxone administration increased mean values of LH and the absolute amplitude of LH peaks, and decreased their frequency in sham-operated rats.
Positive_regulation (increased) of Regulation (values) of LH associated with narcan
5) Confidence 0.46 Published 1994 Journal Vet Hum Toxicol Section Abstract Doc Link 7900272 Disease Relevance 0.35 Pain Relevance 0.45
Different regimens of testosterone replacement (capsules or sc injections) in 8-week ORDX rats significantly reduced the elevated LH value and completely suppressed pulsatile LH secretion.
Positive_regulation (elevated) of Regulation (value) of LH in capsules
6) Confidence 0.44 Published 1988 Journal Endocrinology Section Abstract Doc Link 2840268 Disease Relevance 0.08 Pain Relevance 0.65
We have previously shown that brief periods of exposure to opiate alkaloid drugs markedly enhance the subsequent effects of the opiate antagonist, naloxone, on serum luteinizing hormone (LH) levels in the male rat.
Positive_regulation (enhance) of Regulation (effects) of LH associated with antagonist, narcan and opiate
7) Confidence 0.42 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6096156 Disease Relevance 0 Pain Relevance 0.79
A mechanism by which hyperprolactinemia may change the ability of opiates to influence PRL and LH is by altering the density of opiate receptors.
Spec (may) Positive_regulation (change) of Regulation (influence) of LH associated with galactorrhea and opiate
8) Confidence 0.37 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2559342 Disease Relevance 0.45 Pain Relevance 0.44

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox