INT40315

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Context Info
Confidence 0.76
First Reported 1984
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 5.66
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcc1) Golgi apparatus (Abcc1) ATPase activity (Abcc1)
plasma membrane (Abcc1) nucleus (Abcc1) transmembrane transport (Abcc1)
Anatomy Link Frequency
liver 1
brain 1
Abcc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 6 100.00 Very High Very High Very High
Physical dependence 3 100.00 Very High Very High Very High
tolerance 45 99.84 Very High Very High Very High
Antinociceptive 2 99.30 Very High Very High Very High
Paracetamol 12 97.08 Very High Very High Very High
Buprenorphine 3 92.32 High High
analgesia 1 91.04 High High
methadone 3 85.40 High High
Pain 5 76.28 Quite High
opiate 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 3 100.00 Very High Very High Very High
Breast Cancer 14 99.80 Very High Very High Very High
Gastrointestinal Stromal Tumor 152 99.66 Very High Very High Very High
Injury 6 98.16 Very High Very High Very High
Sarcoma 14 97.88 Very High Very High Very High
Sprains And Strains 5 96.80 Very High Very High Very High
Death 30 96.28 Very High Very High Very High
Apoptosis 71 95.84 Very High Very High Very High
Cancer 228 93.68 High High
Leiomyosarcoma 8 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that differential expression of P-gp and possibly MRP1 contributes to the gestational-induced changes in brain and fetal uptake of saquinavir.
Gene_expression (expression) of MRP1 in brain
1) Confidence 0.76 Published 2009 Journal J Pharm Sci Section Abstract Doc Link 19116954 Disease Relevance 0 Pain Relevance 0.46
Conversely, Mrp1-4 expression was differentially up-regulated.
Gene_expression (expression) of Mrp1
2) Confidence 0.62 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16177239 Disease Relevance 0.28 Pain Relevance 0.47
The present study further characterizes the expression of multidrug resistance-associated proteins 1-4 (Mrp1-4), breast cancer resistance protein (Bcrp) and sodium-taurocholate co-transporting polypeptide (Ntcp) in mouse liver following administration of the hepatotoxicants acetaminophen (APAP) and carbon tetrachloride (CCl4).
Gene_expression (expression) of Mrp1 in liver associated with paracetamol and breast cancer
3) Confidence 0.62 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16177239 Disease Relevance 0.36 Pain Relevance 0.32
Antinociceptive tolerance, cross-tolerance and an expression of physical dependence to morphine (MRP) and (+/-)-ethylketazocine (EKC) were quantitatively compared using two inbred strains of mice.
Gene_expression (expression) of MRP associated with physical dependence, tolerance, sprains and strains, antinociceptive and morphine
4) Confidence 0.52 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6092614 Disease Relevance 0.35 Pain Relevance 1.05
We found the genes sparc, ednrb, junb, cdkn1a, bcl2, ccl5, abcc1 over-expressed and the genes sod1, s100a10 and fth1 under-expressed after inoculation of Tx2-6.
Gene_expression (expressed) of abcc1
5) Confidence 0.31 Published 2009 Journal Toxicon Section Abstract Doc Link 19524607 Disease Relevance 0.08 Pain Relevance 0.08
We found the genes sparc, ednrb, junb, cdkn1a, bcl2, ccl5, abcc1 over-expressed and the genes sod1, s100a10 and fth1 under-expressed after inoculation of Tx2-6.
Gene_expression (expressed) of abcc1
6) Confidence 0.31 Published 2009 Journal Toxicon Section Abstract Doc Link 19524607 Disease Relevance 0.08 Pain Relevance 0.08
Overexpression of Pgp, MDR-associated-protein 1 (MRP1/ABCC1) or ABCG2 has been positively correlated with the evolution of MDR as well as cross-resistance to structurally unrelated anti-neoplastic drugs in a clinical tumor burden [96].
Gene_expression (Overexpression) of ABCC1 associated with cancer
7) Confidence 0.23 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.78 Pain Relevance 0.04
Overexpression of Pgp, MDR-associated-protein 1 (MRP1/ABCC1) or ABCG2 has been positively correlated with the evolution of MDR as well as cross-resistance to structurally unrelated anti-neoplastic drugs in a clinical tumor burden [96].
Gene_expression (Overexpression) of MRP1 associated with cancer
8) Confidence 0.23 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.78 Pain Relevance 0.04
One study of 26 patients with GIST showed 38.4% to express P-glycoprotein and 35.4% expressed MRP1 (multi drug resistance protein).
Gene_expression (expressed) of MRP1 associated with gastrointestinal stromal tumor
9) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 1.32 Pain Relevance 0
One study of 26 patients with GIST showed 38.4% to express P-glycoprotein and 35.4% expressed MRP1 (multi drug resistance protein).
Gene_expression (express) of MRP1 associated with gastrointestinal stromal tumor
10) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 1.34 Pain Relevance 0
Overexpression of ABC transporters such as Pgp, MRP and BCRP has been shown to be responsible for the major portion of MDR.
Gene_expression (Overexpression) of MRP
11) Confidence 0.11 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.31 Pain Relevance 0

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