INT40322

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Context Info
Confidence 0.38
First Reported 1984
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 25
Disease Relevance 11.13
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pnp) extracellular region (Pnp) transferase activity, transferring glycosyl groups (Pnp)
cytoskeleton (Pnp) nucleus (Pnp) intracellular (Pnp)
Anatomy Link Frequency
bile 2
NG108-15 1
Pnp (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 3 99.96 Very High Very High Very High
antagonist 2 99.76 Very High Very High Very High
opiate 3 99.54 Very High Very High Very High
Bile 25 97.72 Very High Very High Very High
dexamethasone 1 88.68 High High
cytokine 1 85.28 High High
Pain 2 77.52 Quite High
Enkephalin 1 71.76 Quite High
anesthesia 63 69.04 Quite High
Inflammation 6 68.32 Quite High
Disease Link Frequency Relevance Heat
Immunization 295 100.00 Very High Very High Very High
Bullous Skin Disease 81 100.00 Very High Very High Very High
Cancer 10 99.98 Very High Very High Very High
Follicular Lymphoma 1 99.52 Very High Very High Very High
Weight Loss 87 98.36 Very High Very High Very High
Glioma 2 98.36 Very High Very High Very High
Neuroblastoma 2 98.22 Very High Very High Very High
Influenza Virus Infection 378 97.92 Very High Very High Very High
Sprains And Strains 288 95.68 Very High Very High Very High
Lymphatic System Cancer 1 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, dalargin associated with PBCA NP and polysorbate 80 induced a potent and prolonged analgesia, which could not be obtained using PS NP in place of PBCA NP.
NP Binding (associated) of
1) Confidence 0.38 Published 1999 Journal Pharm. Res. Section Body Doc Link 10644071 Disease Relevance 0 Pain Relevance 0
Some speculated that the type of tumors associated with PNP may produce plakin proteins that result in initiation of the immune response.
PNP Binding (associated) of associated with cancer and bullous skin disease
2) Confidence 0.28 Published 2004 Journal Beijing Da Xue Xue Bao Section Abstract Doc Link 15489940 Disease Relevance 1.25 Pain Relevance 0.12
At the end of the 120-min perfusion period, PNP could be accounted for entirely as PNP-sulfate (PNP-S) and PNP-glucuronide (PNP-G).
PNP-glucuronide Binding (accounted) of
3) Confidence 0.20 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8971145 Disease Relevance 0 Pain Relevance 0.19
At the end of the 120-min perfusion period, PNP could be accounted for entirely as PNP-sulfate (PNP-S) and PNP-glucuronide (PNP-G).
PNP Binding (accounted) of
4) Confidence 0.20 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8971145 Disease Relevance 0 Pain Relevance 0.19
We conclude that near-term fetal sheep liver can metabolize PNP to PNP-G and PNP-S with efficiencies that may be comparable to those of adults, that, as in adults, sulfation is of low capacity, relative to glucuronidation, and that, unlike adults, fetuses have little capacity to transport the PNP-G formed in the hepatocytes into bile.
PNP Binding (metabolize) of in bile associated with bile
5) Confidence 0.20 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8971145 Disease Relevance 0 Pain Relevance 0.17
At the end of the 120-min perfusion period, PNP could be accounted for entirely as PNP-sulfate (PNP-S) and PNP-glucuronide (PNP-G).
PNP-sulfate Binding (accounted) of
6) Confidence 0.20 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8971145 Disease Relevance 0 Pain Relevance 0.18
We conclude that near-term fetal sheep liver can metabolize PNP to PNP-G and PNP-S with efficiencies that may be comparable to those of adults, that, as in adults, sulfation is of low capacity, relative to glucuronidation, and that, unlike adults, fetuses have little capacity to transport the PNP-G formed in the hepatocytes into bile.
PNP Binding (metabolize) of in bile associated with bile
7) Confidence 0.20 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8971145 Disease Relevance 0 Pain Relevance 0.17
At the end of the 120-min perfusion period, PNP could be accounted for entirely as PNP-sulfate (PNP-S) and PNP-glucuronide (PNP-G).
PNP Binding (accounted) of
8) Confidence 0.17 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8971145 Disease Relevance 0 Pain Relevance 0.18
Rituximab was effective in a patient with PNP associated with CD20+ follicular lymphoma (Borradori et al 2001) and a case of PNP associated with follicular non-HodgkinÂ’s lymphoma (Heizmann et al 2001).
PNP Binding (associated) of associated with lymphatic system cancer, bullous skin disease and follicular lymphoma
9) Confidence 0.09 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936286 Disease Relevance 1.25 Pain Relevance 0.08
Anti-M2 humoral responses were not detectable in most cases, except after DNA/rAd5 immunization with M2 in combination with NP.
NP Neg (except) Binding (combination) of associated with immunization
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.28 Pain Relevance 0
We compared these groups to ferrets immunized with HA alone or in combination with NP+M2.


NP Binding (combination) of
11) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.28 Pain Relevance 0
However, M2 antibodies were only stimulated when M2 was in combination with NP, suggesting possible immune synergy of the two gene products.
NP Binding (combination) of
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.57 Pain Relevance 0
Moreover, while all HA-containing groups were protected against lethal H5N1 challenge with a survival rate of at least 70%, immunization with NP alone did not protect mice from lethal H5N1 challenge (Figure 3).
NP Binding (immunization) of associated with immunization
13) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.72 Pain Relevance 0
Comparative efficacy of DNA/rAd5 vaccination with different combinations of HA, NP and M2 in ferrets
NP Binding (combinations) of
14) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.41 Pain Relevance 0
Significant anti-M2 humoral responses were detected in animals immunized with NP+M2 post-rAd boost (p?
NP Binding (immunized) of
15) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.23 Pain Relevance 0
DNA vaccination with NP in combination with M2 formulated with Vaxfectin has been shown to protect mice against heterosubtypic challenge with H3N2 and H1N1 viruses [7].
NP Binding (vaccination) of
16) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 1.10 Pain Relevance 0
Despite showing no neutralizing antibody responses, mice immunized with HA+NP+M2 were fully protected against lethal challenge.
HA+NP Binding (immunized) of
17) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.85 Pain Relevance 0
Ferrets were immunized with HA alone, NP alone, M2 alone, NP+M2, HA+NP+M2, and control using gene-based vaccines delivered in DNA/rAd5 vectors.
NP Binding (immunized) of
18) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.72 Pain Relevance 0
This finding suggests that NP DNA immunization does not confer protection against H5N1 viral challenge at the doses used here.


NP Binding (immunization) of associated with immunization
19) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.38 Pain Relevance 0
Ferrets were immunized with HA alone, NP alone, M2 alone, NP+M2, HA+NP+M2, and control using gene-based vaccines delivered in DNA/rAd5 vectors.
HA+NP Binding (immunized) of
20) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.72 Pain Relevance 0

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