INT4034

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Context Info
Confidence 0.53
First Reported 1976
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 6.46
Pain Relevance 5.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gip) extracellular region (Gip) cytoplasm (Gip)
Anatomy Link Frequency
plasma 3
fat 1
gum 1
Gip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 18 100.00 Very High Very High Very High
Cholecystokinin 5 99.96 Very High Very High Very High
Enkephalin 30 99.50 Very High Very High Very High
Chronic pancreatitis 17 99.28 Very High Very High Very High
narcan 9 97.76 Very High Very High Very High
tolerance 14 97.24 Very High Very High Very High
Paracetamol 7 96.72 Very High Very High Very High
abdominal pain 1 95.52 Very High Very High Very High
Endogenous opioid 3 92.88 High High
Potency 2 91.68 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 34 99.84 Very High Very High Very High
Pancreatitis 17 99.28 Very High Very High Very High
Celiac Disease 4 99.28 Very High Very High Very High
Disease 4 98.96 Very High Very High Very High
Steatorrhea 9 97.80 Very High Very High Very High
Impaired Glucose Tolerance 17 97.56 Very High Very High Very High
Obesity 4 96.68 Very High Very High Very High
Abdominal Pain 1 95.52 Very High Very High Very High
Apoptosis 2 77.60 Quite High
Gastric Motility Disorder 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reversal of impaired GIP and insulin secretion in patients with pancreatogenic steatorrhea following enzyme substitution.
Negative_regulation (impaired) of GIP associated with steatorrhea
1) Confidence 0.53 Published 1980 Journal Diabetologia Section Title Doc Link 6997121 Disease Relevance 0.50 Pain Relevance 0.12
Both methionine- and leucine-enkephalins caused a dose-dependent inhibition of gastric inhibitory polypeptide (GIP) stimulated SLI secretion.
Negative_regulation (inhibition) of GIP associated with somatostatin and enkephalin
2) Confidence 0.51 Published 1983 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6137272 Disease Relevance 0 Pain Relevance 1.04
Both methionine- and leucine-enkephalins caused a dose-dependent inhibition of gastric inhibitory polypeptide (GIP) stimulated SLI secretion.
Negative_regulation (inhibition) of gastric inhibitory polypeptide associated with somatostatin and enkephalin
3) Confidence 0.51 Published 1983 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6137272 Disease Relevance 0 Pain Relevance 1.04
Vagal stimulation (7 V, 10 Hz, 5 ms) inhibited GIP-stimulated SLI release.
Negative_regulation (inhibited) of GIP-stimulated SLI associated with somatostatin
4) Confidence 0.42 Published 1983 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6137272 Disease Relevance 0 Pain Relevance 1.14
Reversal of impaired GIP and insulin secretion in patients with pancreatogenic steatorrhea following enzyme substitution.
Negative_regulation (Reversal) of GIP associated with steatorrhea
5) Confidence 0.39 Published 1980 Journal Diabetologia Section Title Doc Link 6997121 Disease Relevance 0.50 Pain Relevance 0.12
In patients with chronic pancreatitis improvement of pancreatogenic insufficiency reverses the impaired GIP response, restores the incretin effect of fat, and improves glucose tolerance.
Negative_regulation (impaired) of GIP in fat associated with tolerance, chronic pancreatitis and impaired glucose tolerance
6) Confidence 0.34 Published 1980 Journal Diabetologia Section Abstract Doc Link 6997121 Disease Relevance 0.58 Pain Relevance 0.24
Post-prandial GIP levels were lowered in the guar-gum-supplemented meal and augmented with sugar-beet fibre supplementation.
Negative_regulation (lowered) of GIP in gum
7) Confidence 0.23 Published 1990 Journal Br. J. Nutr. Section Abstract Doc Link 2169302 Disease Relevance 0.43 Pain Relevance 0.29
Serum levels of IR-GIP, IRG and IRI were significantly reduced in patients with coeliac disease.
Negative_regulation (reduced) of GIP associated with celiac disease and disease
8) Confidence 0.15 Published 1976 Journal Diabetologia Section Abstract Doc Link 955338 Disease Relevance 0.85 Pain Relevance 0.16
However, gastric emptying rates, plasma CCK, GIP, insulin, and glucose concentrations were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of GIP in plasma associated with cholecystokinin
9) Confidence 0.15 Published 2003 Journal Physiol. Behav. Section Abstract Doc Link 12782208 Disease Relevance 0 Pain Relevance 0.25
The addition of 200 mg of acarbose to the sucrose load attenuated the sucrose-induced glycaemia and IRI response and completely abolished the IR-GIP release.
Negative_regulation (abolished) of IR-GIP
10) Confidence 0.14 Published 1981 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 7034156 Disease Relevance 0.10 Pain Relevance 0.10
The aim of the present investigation was to evaluate plasma insulin and C-peptide responses to GLP-1 and GIP in five groups of diabetic patients with etiology and phenotype distinct from the obese type 2 diabetic patients.
Negative_regulation (evaluate) of GIP in plasma associated with diabetes mellitus and obesity
11) Confidence 0.07 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 14557471 Disease Relevance 1.20 Pain Relevance 0.08
The loss of GIP action is probably a consequence of diabetes, since it is also observed in patients with diabetes secondary to chronic pancreatitis, in whom the incretin effect is also lost.
Negative_regulation (loss) of GIP associated with diabetes mellitus and chronic pancreatitis
12) Confidence 0.06 Published 2009 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 18786605 Disease Relevance 0.68 Pain Relevance 0.13
The impaired action of GLP-1 and GIP in T2DM may be at least partly restored by improved glycaemic control, as shown in studies involving 4 weeks of intensive insulin therapy.
Negative_regulation (impaired) of GIP associated with diabetes mellitus
13) Confidence 0.06 Published 2009 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 18786605 Disease Relevance 0.76 Pain Relevance 0.13
The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance.
Negative_regulation (impaired) of GIP associated with diabetes mellitus, tolerance, chronic pancreatitis and impaired glucose tolerance
14) Confidence 0.04 Published 2007 Journal Regul. Pept. Section Title Doc Link 17692937 Disease Relevance 0.39 Pain Relevance 0.24
BACKGROUND: The incretin effect is reduced and the insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) is abolished in patients with type 2 diabetes mellitus (T2DM).
Negative_regulation (abolished) of GIP associated with diabetes mellitus
15) Confidence 0.04 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17692937 Disease Relevance 0.40 Pain Relevance 0.19
CONCLUSIONS: The lack of GIP amplification of the late insulin response to iv glucose develops alongside the deterioration of glucose tolerance in patients with CP, suggesting that the same may be true for the loss of the GIP effect in patients with T2DM.


Negative_regulation (loss) of GIP
16) Confidence 0.03 Published 2007 Journal Regul. Pept. Section Body Doc Link 17692937 Disease Relevance 0 Pain Relevance 0
Peak plasma glucose, insulin, and glucose-dependent insulinotropic polypeptide (GIP) responses were reduced when sucrose was given with acarbose.
Negative_regulation (reduced) of insulinotropic in plasma
17) Confidence 0.01 Published 1998 Journal Diabet. Med. Section Abstract Doc Link 9507911 Disease Relevance 0.07 Pain Relevance 0.37

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