INT40345

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Context Info
Confidence 0.67
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.96
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde4b) signal transduction (Pde4b) nucleus (Pde4b)
cytoplasm (Pde4b)
Anatomy Link Frequency
lung 2
macrophages 1
Pde4b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 104 100.00 Very High Very High Very High
antidepressant 7 98.32 Very High Very High Very High
addiction 1 97.96 Very High Very High Very High
cINOD 9 97.92 Very High Very High Very High
cocaine 1 95.92 Very High Very High Very High
Nucleus accumbens 1 82.56 Quite High
monoamine 1 66.88 Quite High
Desipramine 1 66.32 Quite High
fluoxetine 1 65.04 Quite High
Serotonin 1 63.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 109 99.32 Very High Very High Very High
Hyperoxia 98 98.88 Very High Very High Very High
Disease 6 92.08 High High
Pressure And Volume Under Development 3 91.84 High High
Granuloma 1 90.88 High High
Hypoxia 3 90.72 High High
Nicotine Addiction 3 85.60 High High
Pulmonary Disease 33 84.56 Quite High
Adhesions 3 75.52 Quite High
Urological Neuroanatomy 2 74.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of PDE4A and PDE4B may represent a compensatory response to antidepressant treatment and activation of the cAMP system.
Positive_regulation (Upregulation) of PDE4B associated with antidepressant
1) Confidence 0.67 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.14 Pain Relevance 0.57
We found a tendency towards higher PDE4 activity levels after hyperoxia for 6 days in lung tissue homogenates, and reported an increase of a 72 kDa PDE4B protein, presumably PDE4B2 [25].
Positive_regulation (increase) of PDE4B2 in lung associated with hyperoxia
2) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.82 Pain Relevance 0
We found a tendency towards higher PDE4 activity levels after hyperoxia for 6 days in lung tissue homogenates, and reported an increase of a 72 kDa PDE4B protein, presumably PDE4B2 [25].
Positive_regulation (increase) of PDE4B in lung associated with hyperoxia
3) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.81 Pain Relevance 0
Increased cyclic AMP-phosphodiesterase activity during inflammation and its inhibition by anti-inflammatory drugs.
Positive_regulation (Increased) of cyclic AMP-phosphodiesterase associated with inflammation and cinod
4) Confidence 0.20 Published 1984 Journal Eur. J. Pharmacol. Section Title Doc Link 6094215 Disease Relevance 0.59 Pain Relevance 0.46
For example, differentiation of monocytes to macrophages is associated with a marked downregulation of PDE4D3 and PDE4D5, upregulation of PDE4B2 and induction of the PDE4A10 long isoform (Shepherd et al 2004).
Positive_regulation (upregulation) of PDE4B2 in macrophages
5) Confidence 0.10 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.59 Pain Relevance 0.16

General Comments

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