INT40368

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Context Info
Confidence 0.49
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.19
Pain Relevance 3.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (LRP5) plasma membrane (LRP5)
Anatomy Link Frequency
OPS 2
chromaffin cell 1
PAG 1
LRP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Acupuncture 3 99.82 Very High Very High Very High
Catecholamine 9 99.04 Very High Very High Very High
Pain 4 97.92 Very High Very High Very High
Pyramidal cell 2 96.28 Very High Very High Very High
cytokine 8 96.20 Very High Very High Very High
Inflammation 6 96.00 Very High Very High Very High
opiate 6 95.08 Very High Very High Very High
electroacupuncture 4 94.60 High High
long-term potentiation 10 93.68 High High
narcan 4 91.16 High High
Disease Link Frequency Relevance Heat
Cancer 5 99.82 Very High Very High Very High
Pain 3 97.92 Very High Very High Very High
Urological Neuroanatomy 6 97.84 Very High Very High Very High
Nociception 2 97.56 Very High Very High Very High
INFLAMMATION 7 96.00 Very High Very High Very High
Osteoporosis 15 94.40 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 64 91.48 High High
Skin Cancer 3 90.96 High High
Esophageal Cancer 1 88.08 High High
Malignant Neoplastic Disease 1 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neoplasm stained positive for HBM-45 antigen and S-100 protein.
Positive_regulation (positive) of HBM associated with cancer
1) Confidence 0.49 Published 2006 Journal Minerva Chir Section Abstract Doc Link 16568022 Disease Relevance 1.47 Pain Relevance 0.07
OPS enhancement was greatest when tested with low to mid-range stimulus intensities (25 and 50 microA).
Positive_regulation (enhancement) of OPS in OPS
2) Confidence 0.33 Published 1997 Journal Brain Res. Section Abstract Doc Link 9374279 Disease Relevance 0 Pain Relevance 0.51
Significant enhancement of orthodromic population spike (OPS) was found for all stimulus intensities after tetanic stimulation.
Positive_regulation (enhancement) of OPS in OPS
3) Confidence 0.33 Published 1997 Journal Brain Res. Section Abstract Doc Link 9374279 Disease Relevance 0 Pain Relevance 0.51
Several of the HIV protease inhibitors have been shown to alter bone mineral density.50 Recent gene expression profiling has indicated that exposure of osteoblastic cells to nelfinavir and ritonavir increases gene expression of the inflammatory cytokines, MCP-1, and interleukin-8.51 Protease inhibitors have also been suggested to inhibit 1-alpha-hydroxylase, as well as to reduce 1,25(OH)2D levels, which could reduce bone mineral density.45 LRP5, a positive regulator of bone formation, is inhibited by protease inhibitors.51,52
Positive_regulation (regulator) of LRP5 associated with inflammation, acquired immune deficiency syndrome or hiv infection, osteoporosis and cytokine
4) Confidence 0.27 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946855 Disease Relevance 0.90 Pain Relevance 0.12
It was postulated that acupuncture signals activate the brain OPS to exert a double control over the transmission of pain sensation in the PAG, i.e., to block the conveyance of nociceptive impulses at situ and at other relay stations through inhibitory systems.
Spec (postulated) Positive_regulation (activate) of OPS in PAG associated with nociception, pain, urological neuroanatomy and acupuncture
5) Confidence 0.14 Published 1983 Journal Acupunct Electrother Res Section Abstract Doc Link 6145301 Disease Relevance 0.82 Pain Relevance 1.72
Hence, both alterations in some intracellular catecholamine pool and elevations of cAMP levels may trigger increases in the synthesis and processing of OPs and IECPs in the adrenal medullary chromaffin cell.
Positive_regulation (increases) of OPs in chromaffin cell associated with catecholamine
6) Confidence 0.09 Published 1984 Journal J. Neurosci. Section Abstract Doc Link 6094747 Disease Relevance 0 Pain Relevance 0.57

General Comments

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