INT40369

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Context Info
Confidence 0.55
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 5.63
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (LRP5) plasma membrane (LRP5)
Anatomy Link Frequency
osteoblast 1
chromaffin cell 1
LRP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 3 100.00 Very High Very High Very High
Catecholamine 9 98.70 Very High Very High Very High
agonist 3 81.60 Quite High
Opioid 5 75.00 Quite High
adenocard 1 75.00 Quite High
Enkephalin 2 53.40 Quite High
opiate 1 52.24 Quite High
antagonist 7 51.68 Quite High
vincristine 1 17.12 Low Low
dexamethasone 2 10.72 Low Low
Disease Link Frequency Relevance Heat
Cancer 81 99.68 Very High Very High Very High
Mental Disorders 176 99.40 Very High Very High Very High
Osteogenic Sarcomas 2 99.36 Very High Very High Very High
Recurrence 84 98.96 Very High Very High Very High
Osteoporosis 8 98.92 Very High Very High Very High
Metastasis 4 97.48 Very High Very High Very High
Disease 75 96.56 Very High Very High Very High
Syndrome 3 95.00 High High
Disease Progression 1 93.44 High High
Congenital Anomalies 5 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OPs participating in this study are employed at this OHS and are affiliated with companies of different sizes, in different sectors and in different parts of the Netherlands.
Gene_expression (employed) of OPs
1) Confidence 0.55 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2841673 Disease Relevance 0 Pain Relevance 0
All participating OPs work for the same OHS and are stimulated to contribute to the study by this OHS.
Gene_expression (work) of OPs
2) Confidence 0.55 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2841673 Disease Relevance 0.13 Pain Relevance 0
OPs are trained in diagnosing mental disorders and use a nationwide coding system, Classification of Diseases (in Dutch: CAS) [27], based on the International Classification of Diseases [28].
Gene_expression (trained) of OPs associated with mental disorders and disease
3) Confidence 0.55 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2841673 Disease Relevance 0.61 Pain Relevance 0
In practice, OPs do not seem to act upon this last step of the guideline (Rebergen et al., submitted for publication).


Gene_expression (act) of OPs
4) Confidence 0.55 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2841673 Disease Relevance 0.41 Pain Relevance 0
In 94 (39.0%) of the patients, other procedures were coded: in 56 (23.2%) patients, endoscopic procedures (OPS 1-63, 1-64,1-65), in 24 (10.0%) patients, imaging procedures (OPS 3.x), in 13 (5.4%) patients, pulmonary procedures (OPS 1-7.x), in seven (2.9%) of the patients both surgical and non-surgical procedures (OPS 5 and 8) and in 4 (1.6%) patients, neurological procedures (OPS 1-20.x).
Gene_expression (procedures) of OPS associated with imagery
5) Confidence 0.41 Published 2004 Journal GMS Psycho-Social Medicine Section Body Doc Link PMC2736487 Disease Relevance 0.61 Pain Relevance 0.05
In 94 (39.0%) of the patients, other procedures were coded: in 56 (23.2%) patients, endoscopic procedures (OPS 1-63, 1-64,1-65), in 24 (10.0%) patients, imaging procedures (OPS 3.x), in 13 (5.4%) patients, pulmonary procedures (OPS 1-7.x), in seven (2.9%) of the patients both surgical and non-surgical procedures (OPS 5 and 8) and in 4 (1.6%) patients, neurological procedures (OPS 1-20.x).
Gene_expression (procedures) of OPS associated with imagery
6) Confidence 0.41 Published 2004 Journal GMS Psycho-Social Medicine Section Body Doc Link PMC2736487 Disease Relevance 0.61 Pain Relevance 0.05
In 94 (39.0%) of the patients, other procedures were coded: in 56 (23.2%) patients, endoscopic procedures (OPS 1-63, 1-64,1-65), in 24 (10.0%) patients, imaging procedures (OPS 3.x), in 13 (5.4%) patients, pulmonary procedures (OPS 1-7.x), in seven (2.9%) of the patients both surgical and non-surgical procedures (OPS 5 and 8) and in 4 (1.6%) patients, neurological procedures (OPS 1-20.x).
Gene_expression (procedures) of OPS associated with imagery
7) Confidence 0.41 Published 2004 Journal GMS Psycho-Social Medicine Section Body Doc Link PMC2736487 Disease Relevance 0.84 Pain Relevance 0.05
Patients with LRP5 expression in the tumor showed decreased event free survival.
Gene_expression (expression) of LRP5 associated with cancer
8) Confidence 0.31 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.52 Pain Relevance 0.03
It has also been shown that mice with targeted disruptions of LRP-5 expression have a decreased level of osteoblast proliferation and display a phenotype similar to humans with osteoporosis–pseudoglioma syndrome [69].
Gene_expression (expression) of LRP-5 in osteoblast associated with syndrome and osteoporosis
9) Confidence 0.26 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.59 Pain Relevance 0
In the aggregated variable, expressing the number of times sprayed and whether or not OPs were used, the mean ChE activity was found to be depending on the degree of pesticide exposure as seen in Table 4.
Gene_expression (expressing) of OPs
10) Confidence 0.19 Published 2006 Journal Environ Health Section Body Doc Link PMC1464129 Disease Relevance 0.31 Pain Relevance 0
Hence, both alterations in some intracellular catecholamine pool and elevations of cAMP levels may trigger increases in the synthesis and processing of OPs and IECPs in the adrenal medullary chromaffin cell.
Gene_expression (synthesis) of OPs in chromaffin cell associated with catecholamine
11) Confidence 0.12 Published 1984 Journal J. Neurosci. Section Abstract Doc Link 6094747 Disease Relevance 0 Pain Relevance 0.57

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