INT40408

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Context Info
Confidence 0.58
First Reported 1980
Last Reported 1984
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Gnrh1 (Rattus norvegicus)
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 12 99.40 Very High Very High Very High
narcan 9 97.24 Very High Very High Very High
opiate 7 96.48 Very High Very High Very High
Neurotransmitter 1 85.72 High High
Endogenous opioid 2 83.24 Quite High
opioid receptor 1 76.32 Quite High
Enkephalin 1 72.40 Quite High
Opioid 1 71.16 Quite High
antagonist 1 60.80 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increase in the serum LH induced by exogenous LHRH was slightly potentiated and not inhibited by a large dose of morphine, in both intact and castrated rats.
Positive_regulation (Increase) of LHRH Positive_regulation (induced) of serum LH associated with morphine
1) Confidence 0.58 Published 1980 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6776920 Disease Relevance 0 Pain Relevance 1.00
A modest facilitation of LHRH-evoked increases in serum LH was also observed, but our data suggest that this represents only a minor component of opiate-induced enhancements of naloxone's effects.
Positive_regulation (facilitation) of LHRH-evoked Positive_regulation (increases) of LH associated with narcan and opiate
2) Confidence 0.48 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6096156 Disease Relevance 0 Pain Relevance 1.22

General Comments

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