INT40436

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Context Info
Confidence 0.70
First Reported 1984
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 21
Total Number 23
Disease Relevance 8.09
Pain Relevance 6.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Eda) cell differentiation (Eda) extracellular region (Eda)
plasma membrane (Eda)
Anatomy Link Frequency
hypothalamus 3
macrophages 2
whiskers 2
pituitary 2
epithelial cells 1
Eda (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 187 99.78 Very High Very High Very High
Snapping jaw 126 99.52 Very High Very High Very High
amygdala 2 99.08 Very High Very High Very High
midbrain 2 98.52 Very High Very High Very High
trigeminal ganglion 121 97.84 Very High Very High Very High
antagonist 29 94.52 High High
allodynia 24 93.24 High High
Hyperalgesia 10 92.68 High High
Central nervous system 80 90.60 High High
Eae 53 90.52 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 216 99.78 Very High Very High Very High
Temporomandibular Joint Syndrome 126 99.52 Very High Very High Very High
Sprains And Strains 110 99.36 Very High Very High Very High
Ganglion Cysts 121 97.84 Very High Very High Very High
Gliosis 16 97.56 Very High Very High Very High
Heart Rate Under Development 3 97.44 Very High Very High Very High
Infection 58 96.00 Very High Very High Very High
Cold Sores 122 93.36 High High
Neuropathic Pain 51 93.24 High High
Hyperalgesia 10 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In hypothalamus, ovariectomy increased both S and MB EDA activities, whereas E replacement returned them to control levels, although MB EDA activity increased again after the replacement with 40 mg/kg E.
Positive_regulation (increased) of EDA in hypothalamus
1) Confidence 0.70 Published 2005 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 15748714 Disease Relevance 0 Pain Relevance 0.23
In hypothalamus, ovariectomy increased both S and MB EDA activities, whereas E replacement returned them to control levels, although MB EDA activity increased again after the replacement with 40 mg/kg E.
Positive_regulation (increased) of EDA in hypothalamus
2) Confidence 0.70 Published 2005 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 15748714 Disease Relevance 0 Pain Relevance 0.22
P replacement increased S EDA activity, but returned MB EDA activity to control levels.
Positive_regulation (increased) of EDA
3) Confidence 0.70 Published 2005 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 15748714 Disease Relevance 0 Pain Relevance 0.22
In pituitary, neither ovariectomy nor the replacement of E or E+P changed S EDA, although the highest concentrations of P increased S EDA activity.
Positive_regulation (increased) of EDA in pituitary
4) Confidence 0.61 Published 2005 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 15748714 Disease Relevance 0 Pain Relevance 0.19
On the other hand, in adrenal glands, orchidectomy increased S and MB EDA activities, whereas T replacement returned both activities to control levels.
Positive_regulation (increased) of MB EDA in adrenal glands
5) Confidence 0.60 Published 2003 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 14636637 Disease Relevance 0 Pain Relevance 0.22
In hypothalamus, orchidectomy did not modify either S or MB EDA, although T replacement increased S but not MB EDA.
Neg (not) Positive_regulation (increased) of MB EDA in hypothalamus
6) Confidence 0.60 Published 2003 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 14636637 Disease Relevance 0 Pain Relevance 0.24
The replacement of E+P returned both S and MB EDA activities to control levels, although MB EDA activity was lower than control values after the replacement with 10+100 mg/kg E+P.
Positive_regulation (returned) of EDA
7) Confidence 0.50 Published 2005 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 15748714 Disease Relevance 0 Pain Relevance 0.21
In pituitary, neither ovariectomy nor the replacement of E or E+P changed S EDA, although the highest concentrations of P increased S EDA activity.
Neg (nor) Positive_regulation (changed) of EDA in pituitary
8) Confidence 0.50 Published 2005 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 15748714 Disease Relevance 0 Pain Relevance 0.19
P replacement increased S EDA activity, but returned MB EDA activity to control levels.
Positive_regulation (returned) of EDA
9) Confidence 0.50 Published 2005 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 15748714 Disease Relevance 0 Pain Relevance 0.22
However, ovariectomy increased MB EDA and E replacement returned the activity to control or below control levels, depending on the concentration used.
Positive_regulation (increased) of EDA
10) Confidence 0.44 Published 2005 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 15748714 Disease Relevance 0 Pain Relevance 0.14
There was no overall effect of exposure to novelty, but some strains showed either a decrease or an increase in beta-ED levels in the septum, amygdala, and midbrain.
Positive_regulation (increase) of beta-ED in midbrain associated with midbrain, sprains and strains and amygdala
11) Confidence 0.36 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9678655 Disease Relevance 0.64 Pain Relevance 0.43
In particular, following induction of TMJ inflammation, a strong upregulation of ED1 (a specific marker for activated macrophages) [38] in the ipsilateral TG was found.
Positive_regulation (upregulation) of ED1 in macrophages associated with snapping jaw, inflammation and trigeminal ganglion
12) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 1.56 Pain Relevance 1.19
There was no overall effect of exposure to novelty, but some strains showed either a decrease or an increase in beta-ED levels in the septum, amygdala, and midbrain.
Positive_regulation (increase) of beta-ED in amygdala associated with midbrain, sprains and strains and amygdala
13) Confidence 0.12 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9678655 Disease Relevance 0.64 Pain Relevance 0.43
Marked increases in both ED1 and GFAP ir were evident following QUIN compared with PBS control (upper and middle left panels, Fig. 1B).
Positive_regulation (increases) of ED1 in upper
14) Confidence 0.10 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430697 Disease Relevance 0.32 Pain Relevance 0.12
This is at variance from previous reports indicating an increase in ED1 immunoreactivity in the DRG following CFA-induced inflammation of the footpad or of the knee joint [37,62] which the authors attributed to macrophage infiltration.
Positive_regulation (increase) of ED1 in macrophage associated with inflammation
15) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 1.26 Pain Relevance 0.90
Both analyses demonstrated a significant increase of ED1 immunostaining in the three divisions of ipsilateral TG with respect to the contralateral side at 24 h after CFA injection, with the highest effect detected in the V3-mandibular division (densitometric analysis: 111.39 ± 16.71 pixels for the ipsilateral side vs. 36.44 ± 10.73 pixels for the contralateral side, p < 0.01, n = 6 animals; number of ED1+ cells: 18.19 ± 2.10 cells for the ipsilateral side vs. 8.18 ± 0.96 cells for the contralateral side, p < 0.01; n = 7 animals; Figure 4E, H).
Positive_regulation (increase) of ED1 in mandibular division associated with trigeminal ganglion
16) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.48 Pain Relevance 0.28
Both ED1 and GFAP ir were increased with QUIN stimulation from 6 hr to 1 d, however, both markers demonstrated no additional increases for the longest duration of QUIN injection at 7 d.
Positive_regulation (increased) of ED1
17) Confidence 0.07 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430697 Disease Relevance 0.21 Pain Relevance 0.07
Significant elevation in beta-ED concentration was observed in the severely apneic infants with bradycardia when compared to the other two groups.
Positive_regulation (elevation) of beta-ED associated with heart rate under development
18) Confidence 0.06 Published 1984 Journal Am J Perinatol Section Abstract Doc Link 6097281 Disease Relevance 0.64 Pain Relevance 0.08
Notably, in PVG rats higher mRNA expression of Toll-like receptors (Tlr) -2 and -9, together with increased staining for Iba1/ED1 was detected in the whiskers area.
Positive_regulation (increased) of ED1 in whiskers
19) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2929186 Disease Relevance 1.09 Pain Relevance 0
In the whiskers area of DA rats from 2 dpi there was lower and delayed activation of Iba1+ (Figure 4C) and ED1+ (Figure 4M) (asterisk in Figure 3C, 3E, 4E), as well as of CD11b/c+ cells (Table1) compared to the PVG rats (asterisk in Figure 3D and 3F), despite the fact that more HSV-1 staining was visible in this area in DA rats.
Positive_regulation (activation) of ED1 in whiskers associated with cold sores
20) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.48 Pain Relevance 0

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