INT4046

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Context Info
Confidence 0.69
First Reported 1976
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 42
Total Number 48
Disease Relevance 13.66
Pain Relevance 8.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBG2) transport (HBG2)
Anatomy Link Frequency
blood 6
coronary artery 2
erythrocytes 2
platelet 1
body 1
HBG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 22 99.70 Very High Very High Very High
lidocaine 40 99.44 Very High Very High Very High
cytokine 22 97.52 Very High Very High Very High
Angina 10 96.48 Very High Very High Very High
headache 24 95.80 Very High Very High Very High
analgesia 11 95.68 Very High Very High Very High
anesthesia 51 92.88 High High
Pain 17 92.76 High High
cva 75 90.56 High High
Serotonin 4 85.96 High High
Disease Link Frequency Relevance Heat
Methemoglobinemia 158 99.60 Very High Very High Very High
Toxicity 170 99.30 Very High Very High Very High
Anaemia 15 98.86 Very High Very High Very High
Hypoxia 15 98.76 Very High Very High Very High
Hemolysis 7 98.72 Very High Very High Very High
Injury 11 98.24 Very High Very High Very High
Increased Venous Pressure Under Development 108 97.96 Very High Very High Very High
Ventricular Heart Septal Defects 7 97.96 Very High Very High Very High
Coronary Artery Disease 9 97.60 Very High Very High Very High
Cv General 3 Under Development 10 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine if ordinary doses of nitrates produce a significant increase in methemoglobin, methemoglobin levels were measured in 59 randomly selected patients with coronary artery disease and unstable angina pectoris who were receiving organic nitrate therapy.
Positive_regulation (increase) of methemoglobin in coronary artery associated with angina and coronary artery disease
1) Confidence 0.69 Published 1984 Journal J Clin Pharmacol Section Abstract Doc Link 6427300 Disease Relevance 0.36 Pain Relevance 0.19
Elevation of methemoglobin levels after lidocaine administration was statistically significant (P less than .05), but not clinically significant.
Positive_regulation (Elevation) of methemoglobin associated with lidocaine
2) Confidence 0.69 Published 1987 Journal Ann Emerg Med Section Abstract Doc Link 3813168 Disease Relevance 0.08 Pain Relevance 0.74
Methemoglobin levels measured in rats of the same age were elevated significantly 30 and 60 min after butyl nitrite to levels of 30-45%.
Positive_regulation (elevated) of Methemoglobin
3) Confidence 0.69 Published 1989 Journal Fundam Appl Toxicol Section Abstract Doc Link 2925018 Disease Relevance 0.40 Pain Relevance 0.07
RESULTS: There was a dose-dependent increase of methemoglobin due to addition of o-toluidine after 360 min in vitro.
Positive_regulation (increase) of methemoglobin
4) Confidence 0.69 Published 2003 Journal Anaesthesist Section Body Doc Link 14992088 Disease Relevance 0.05 Pain Relevance 0
Two patients had an increase of the methemoglobin concentration to more than 11% after the administration of prilocaine.
Positive_regulation (increase) of methemoglobin
5) Confidence 0.69 Published 1987 Journal Reg Anaesth Section Abstract Doc Link 3303178 Disease Relevance 0.09 Pain Relevance 0.31
The decrease of oxygen saturation and the increase of methemoglobin were also observed in the finding of blood gas analysis.
Positive_regulation (increase) of methemoglobin in blood
6) Confidence 0.69 Published 2000 Journal Masui Section Abstract Doc Link 10933033 Disease Relevance 0.58 Pain Relevance 0.17
In the in vivo study plexus anesthesia with prilocaine resulted in an increase of the methemoglobin concentration with a maximum after 120-180 min.
Positive_regulation (increase) of methemoglobin
7) Confidence 0.69 Published 2003 Journal Anaesthesist Section Body Doc Link 14992088 Disease Relevance 0 Pain Relevance 0
The elevated methemoglobin levels were found in 8 patients.
Positive_regulation (elevated) of methemoglobin
8) Confidence 0.69 Published 1996 Journal Prz. Lek. Section Abstract Doc Link 8711189 Disease Relevance 0.35 Pain Relevance 0.08
In the bupivacaine group, methemoglobin levels increased only at 5 hours of local anesthetic administration.
Positive_regulation (increased) of methemoglobin
9) Confidence 0.68 Published 2008 Journal Middle East J Anesthesiol Section Body Doc Link 18637601 Disease Relevance 0 Pain Relevance 0
CONCLUSION: The use of prilocaine in epidural anesthesia for renal transplantation surgery resulted in an increase in methemoglobin levels, which did not cause any clinical symptoms and was similar to those of bupivacaine at all time measurements.


Positive_regulation (increase) of methemoglobin
10) Confidence 0.68 Published 2008 Journal Middle East J Anesthesiol Section Body Doc Link 18637601 Disease Relevance 0 Pain Relevance 0
If exposure to an oxidizer such as nitrate is increasing methemoglobin level, it can be readily reduced back to hemoglobin once the oxidizer is removed.
Positive_regulation (increasing) of methemoglobin
11) Confidence 0.67 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.07 Pain Relevance 0
Methemoglobin levels increased gradually, reached a plateau 2 hours after beginning of the infusion (Figure 1A; maximal level, 1.6±0.5%), and remained elevated until 30 minutes after the infusion ended, before returning to baseline within 1 hour of infusion cessation.
Positive_regulation (increased) of Methemoglobin
12) Confidence 0.63 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018414 Disease Relevance 0 Pain Relevance 0
In subject 11, the methemoglobin level increased above 5% 2 minutes after sodium nitrite infusion cessation (Figure 3A,B).
Positive_regulation (increased) of methemoglobin
13) Confidence 0.63 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018414 Disease Relevance 0.05 Pain Relevance 0
The dose limiting toxicity was restricted to an asymptomatic increase of methemoglobin and, clinically irrelevant, a transient decrease of blood pressure.
Positive_regulation (increase) of methemoglobin in blood associated with toxicity
14) Confidence 0.63 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018414 Disease Relevance 0.26 Pain Relevance 0
Methemoglobin levels increased gradually, reached a plateau 2 hours after beginning of the infusion (Figure 1A; maximal level, 1.6±0.5%), and remained elevated until 30 minutes after the infusion ended, before returning to baseline within 1 hour of infusion cessation.
Positive_regulation (elevated) of Methemoglobin
15) Confidence 0.63 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018414 Disease Relevance 0 Pain Relevance 0
The methemoglobin value was elevated significantly above baseline after intravenous administration (p = 0.03), but not after penile application of EMLA.
Neg (not) Positive_regulation (elevated) of methemoglobin
16) Confidence 0.60 Published 1995 Journal Biol. Neonate Section Abstract Doc Link 8835088 Disease Relevance 0.07 Pain Relevance 0.29
In acetaminophen incubated erythrocytes, methemoglobin concentration and superoxide dismutase activity were increased in a dose and incubation-time dependent manner, the activity of Na(+)-K+ ATPase was decreased by acetaminophen treatment.
Positive_regulation (increased) of methemoglobin in erythrocytes associated with paracetamol
17) Confidence 0.59 Published 1995 Journal Biochem. Mol. Biol. Int. Section Abstract Doc Link 7627122 Disease Relevance 0 Pain Relevance 0.53
Lower dosages of phenazopyridine (10 and 20 mg/kg/day) for longer periods of administration to 2 other clinically normal cats did not result in illness or anemia; however, the number and size of Heinz bodies and blood methemoglobin content were increased.
Positive_regulation (increased) of methemoglobin in blood associated with anaemia
18) Confidence 0.53 Published 1976 Journal J. Am. Vet. Med. Assoc. Section Abstract Doc Link 956020 Disease Relevance 0.65 Pain Relevance 0.07
The proportion of patients with elevated methemoglobin concentration increased from the control to group A to group B.
Positive_regulation (elevated) of methemoglobin
19) Confidence 0.50 Published 1984 Journal J Clin Pharmacol Section Abstract Doc Link 6427300 Disease Relevance 0.31 Pain Relevance 0.16
Although under physiological conditions, ascorbic acid-induced methemoglobin reduction is less important than reduction by the NADP-dependent methemoglobin reductase system, under methemoglobinemic conditions, treatment with ascorbic acid is possible.
Positive_regulation (induced) of methemoglobin
20) Confidence 0.48 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829598 Disease Relevance 0.38 Pain Relevance 0.21

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