INT40478

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Context Info
Confidence 0.48
First Reported 1984
Last Reported 2011
Negated 1
Speculated 2
Reported most in Abstract
Documents 23
Total Number 24
Disease Relevance 12.77
Pain Relevance 14.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NCOR2) small molecule metabolic process (NCOR2) nucleolus (NCOR2)
nucleus (NCOR2) DNA binding (NCOR2)
Anatomy Link Frequency
brain 2
neuronal 1
vasculature 1
mast cells 1
T-cells 1
NCOR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 33 100.00 Very High Very High Very High
Serotonin 4 100.00 Very High Very High Very High
Cholecystokinin 1 100.00 Very High Very High Very High
agonist 196 99.98 Very High Very High Very High
Morphine 25 99.98 Very High Very High Very High
Pain 25 99.98 Very High Very High Very High
Central nervous system 117 99.74 Very High Very High Very High
diffuse noxious inhibitory control 8 99.38 Very High Very High Very High
Enkephalin 26 99.32 Very High Very High Very High
Neurotransmitter 41 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 26 99.98 Very High Very High Very High
Coma 10 99.38 Very High Very High Very High
Sleep Disorders 141 99.04 Very High Very High Very High
Neuroblastoma 11 98.84 Very High Very High Very High
Sclerosis 2 98.64 Very High Very High Very High
Epilepsy 4 97.20 Very High Very High Very High
Migraine Disorders 14 96.44 Very High Very High Very High
Substance Withdrawal Syndrome 15 95.80 Very High Very High Very High
Thyroid Disease 2 94.20 High High
Depression 26 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All these drugs were found to block both human receptors.
Negative_regulation (block) of receptors
1) Confidence 0.48 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8743744 Disease Relevance 0.51 Pain Relevance 0.87
To test this hypothesis, we analyzed the impact of NCOR2 siRNA interference on TGF?
Spec (analyzed) Negative_regulation (interference) of NCOR2
2) Confidence 0.40 Published 2011 Journal Nucleic Acids Research Section Body Doc Link PMC3017614 Disease Relevance 0.08 Pain Relevance 0
Compared to single pulses, double and triple pulses increased the sensation of pain, reduced the tactile and pain thresholds, and facilitated the blink reflex responses (reduced onset latency, increased magnitude and persistence of nR2).
Negative_regulation (persistence) of nR2 associated with pain
3) Confidence 0.37 Published 2004 Journal Pain Section Abstract Doc Link 15109515 Disease Relevance 0.84 Pain Relevance 0.68
Activation of the DNIC system using heterotopic pain suppressed the nR2 evoked by double and triple stimulation by 16 and 42%, respectively, but not the nR2 from a single pulse.
Negative_regulation (suppressed) of nR2 associated with pain and diffuse noxious inhibitory control
4) Confidence 0.37 Published 2004 Journal Pain Section Abstract Doc Link 15109515 Disease Relevance 0.85 Pain Relevance 0.72
The prophylactic effect of these drugs has been suggested to be caused through blockade of serotonin (5-HT) receptors of type 5-HT2B or 5-HT2C.
Negative_regulation (blockade) of receptors associated with serotonin
5) Confidence 0.36 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8743744 Disease Relevance 0.38 Pain Relevance 0.58
The lack of dynorphin A effects in patients showing mossy fiber sprouting compares well to the loss of kappa receptors on granule cells in Ammon's horn sclerosis but not lesion-associated epilepsy.
Neg (not) Negative_regulation (loss) of receptors in Ammon's horn associated with epilepsy, dynorphin and sclerosis
6) Confidence 0.28 Published 1999 Journal Neuroscience Section Abstract Doc Link 10579209 Disease Relevance 0.46 Pain Relevance 0.61
On the other hand, downregulation of NMDA, kainate, and quisqualate receptors is most likely to induce a state of CNS hyperexcitability that involves different neuronal pools and reverberating circuits [27].
Negative_regulation (downregulation) of receptors in neuronal associated with central nervous system and hyperexcitability
7) Confidence 0.04 Published 2000 Journal Crit Care Section Body Doc Link PMC137331 Disease Relevance 0.31 Pain Relevance 1.22
The drug may also inhibit catecholamine receptors and reuptake of various neurotransmitters in the mid-brain.
Spec (may) Negative_regulation (inhibit) of receptors in brain associated with neurotransmitter and catecholamine
8) Confidence 0.04 Published 2000 Journal Crit Care Section Body Doc Link PMC137331 Disease Relevance 0.89 Pain Relevance 0.37
Kainate and quisqualate channels appear to be blocked only by higher alcohol concentrations that clinically produce sedation, stupor and coma in humans, suggesting that inhibition of these receptors is associated with the anesthetic properties of ethanol.
Negative_regulation (inhibition) of receptors associated with sleep disorders, coma and alcohol
9) Confidence 0.04 Published 2000 Journal Crit Care Section Body Doc Link PMC137331 Disease Relevance 0.49 Pain Relevance 0.94
Conversely, the delta antagonist (N,N-diallyl-Tyr-Aib-Aib-Phe-Leu-OH([N,N-diallyl-Tyr1, Aib2,3]Leu- enkephalin)] ICI 174,864 blocked morphine-induced down-regulation of delta but not mu receptors.
Negative_regulation (down-regulation) of receptors associated with antagonist, enkephalin and morphine
10) Confidence 0.04 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932156 Disease Relevance 0.16 Pain Relevance 1.00
The selective mu agonist Tyr-Pro-MePhe-D-Pro-NH2 (PL017) down-regulated mu receptors with a half-maximal effect at 180 nM, but was without effect on delta receptors at concentrations up to 10 microM.
Negative_regulation (down-regulated) of receptors associated with agonist
11) Confidence 0.04 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932156 Disease Relevance 0.07 Pain Relevance 0.70
Morphine down-regulated both mu and delta receptors, but its effects on each subtype could be dissociated by use of specific antagonists.
Negative_regulation (down-regulated) of receptors associated with antagonist and morphine
12) Confidence 0.04 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932156 Disease Relevance 0.17 Pain Relevance 0.93
Based on commonalities between peripheral blood "immunocytes" and central nervous system cells (both have receptors for endorphins, enkephalins, dopamine, acetylcholine, etc.) blocking of potassium ion channels in both brain cell synaptosome and suppressor T cells, and common sharing of antigenic determinants on one or another immunocyte and one or another CNS cells, we postulated that peripheral blood immunocytes can be used to study CNS mechanisms.
Negative_regulation (have) of receptors in brain associated with dopamine, enkephalin and central nervous system
13) Confidence 0.03 Published 1984 Journal Biomed. Pharmacother. Section Abstract Doc Link 6098318 Disease Relevance 0.19 Pain Relevance 0.20
Withdrawal symptoms result from a compensatory increase in the activity of excitatory mechanisms (upregulation) involving the neurotransmitters norepinephrine, dopamine, and the N-methyl-D-aspartate (NMDA) receptor, and diminished activity (downregulation) of the inhibitory receptors  ?
Negative_regulation (diminished) of receptors associated with dopamine, neurotransmitter and withdrawal
14) Confidence 0.03 Published 2000 Journal Crit Care Section Body Doc Link PMC137331 Disease Relevance 2.06 Pain Relevance 0.84
Withdrawal symptoms result from a compensatory increase in the activity of excitatory mechanisms (upregulation) involving the neurotransmitters norepinephrine, dopamine, and the N-methyl-D-aspartate (NMDA) receptor, and diminished activity (downregulation) of the inhibitory receptors  ?
Negative_regulation (downregulation) of receptors associated with dopamine, neurotransmitter and withdrawal
15) Confidence 0.03 Published 2000 Journal Crit Care Section Body Doc Link PMC137331 Disease Relevance 2.05 Pain Relevance 0.83
Thus, down-regulation of mu and delta receptors was homologous, because selective agonists down-regulated their respective receptors without effect on the heterologous opiate receptor.
Negative_regulation (down-regulation) of receptors associated with agonist and opiate
16) Confidence 0.03 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932156 Disease Relevance 0.07 Pain Relevance 0.62
Thus, down-regulation of mu and delta receptors was homologous, because selective agonists down-regulated their respective receptors without effect on the heterologous opiate receptor.
Negative_regulation (down-regulated) of receptors associated with agonist and opiate
17) Confidence 0.03 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932156 Disease Relevance 0.07 Pain Relevance 0.62
Novel mechanisms to stimulate GI motility and transit include blockade of cholecystokinin (CCK)A receptors and stimulation of motilin receptors.
Negative_regulation (blockade) of receptors associated with cholecystokinin
18) Confidence 0.02 Published 1999 Journal Can. J. Gastroenterol. Section Abstract Doc Link 10202210 Disease Relevance 0.27 Pain Relevance 0.80
They are widely co-expressed on immune cells, including neutrophils, CD8(+) T-cells and mast cells, and allosteric inhibitors of these receptors have been suggested to offer a general means to inhibit polymorphonuclear cell recruitment in vivo [15].
Negative_regulation (inhibitors) of receptors in T-cells
19) Confidence 0.01 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.12 Pain Relevance 0.65
For example, the neonatal pulmonary vasculature appears to be deficient in dopaminergic receptors [2, 5], whereas ?
Negative_regulation (deficient) of receptors in vasculature
20) Confidence 0.01 Published 2001 Journal Crit Care Section Body Doc Link PMC31580 Disease Relevance 0.84 Pain Relevance 0.18

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