INT40479

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Context Info
Confidence 0.52
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.26
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SIGMAR1) nuclear envelope (SIGMAR1) lipid particle (SIGMAR1)
endoplasmic reticulum (SIGMAR1) plasma membrane (SIGMAR1) nucleus (SIGMAR1)
Anatomy Link Frequency
spinal 1
SIGMAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 11 100.00 Very High Very High Very High
Immobilon 14 99.80 Very High Very High Very High
agonist 25 98.80 Very High Very High Very High
Enkephalin 3 95.36 Very High Very High Very High
Opioid 1 93.12 High High
intrathecal 2 92.00 High High
antagonist 2 90.48 High High
Neuropathic pain 2 87.44 High High
allodynia 1 75.00 Quite High
fortral 2 66.24 Quite High
Disease Link Frequency Relevance Heat
Nociception 1 99.96 Very High Very High Very High
Apoptosis 1 97.76 Very High Very High Very High
Neuroblastoma 7 92.36 High High
Schizophrenia 8 91.08 High High
Small Cell Lung Cancer 3 82.68 Quite High
Psychosis 2 76.36 Quite High
Neuropathic Pain 3 75.00 Quite High
Cancer 2 75.00 Quite High
Depression 3 25.00 Low Low
Dementia 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, immunologic deficiency might hinder elimination of neurotropic viruses which in genetically predisposed individuals bind to and block the sigma receptor.
Negative_regulation (block) of sigma receptor
1) Confidence 0.52 Published 1984 Journal Biomed. Pharmacother. Section Abstract Doc Link 6098318 Disease Relevance 0.41 Pain Relevance 0.11
The sigma receptor was originally proposed to be a subtype of the opioid receptor.
Negative_regulation (subtype) of sigma receptor associated with opioid receptor
2) Confidence 0.37 Published 2004 Journal CNS Drugs Section Abstract Doc Link 15089113 Disease Relevance 0 Pain Relevance 0.26
BACKGROUND: Selective blockade of spinal sigma(1) receptors (Sig-1R) suppresses nociceptive behaviors in the mouse formalin test.
Negative_regulation (blockade) of Sig-1R in spinal associated with nociception
3) Confidence 0.22 Published 2008 Journal Anesthesiology Section Abstract Doc Link 18946301 Disease Relevance 0.25 Pain Relevance 0.40
Altogether, these results indicate that the sigma-1 receptor-induced inhibition of the cell cycle is, at least in part, the consequence of the inhibition of K+ channels.
Negative_regulation (inhibition) of sigma-1 receptor
4) Confidence 0.07 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15277583 Disease Relevance 0.31 Pain Relevance 0.16
In a previous work, we described a differential desensitization of the human delta-opioid receptor (hDOP-R) by etorphine (a non-selective and alkaloid agonist) and delta-selective and peptidic agonists (DPDPE ([D-Pen(2,5)]enkephalin) and deltorphin I (Tyr-D-Ala-Phe-Asp-Val-Val-Gly-NH(2))) in the neuroblastoma cell line SK-N-BE (Allouche et al., Eur.
Negative_regulation (desensitization) of hDOP-R associated with neuroblastoma, agonist, enkephalin, opioid receptor and immobilon
5) Confidence 0.00 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18395423 Disease Relevance 0.17 Pain Relevance 0.43
In conclusion, hDOP-R desensitization upon etorphine exposure relies on the GRK2, PKC and tyrosine kinases while DPDPE and deltorphin I mediate desensitization at least via tyrosine kinases.
Negative_regulation (desensitization) of hDOP-R associated with immobilon
6) Confidence 0.00 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18395423 Disease Relevance 0.13 Pain Relevance 0.51

General Comments

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