INT40486

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Context Info
Confidence 0.48
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 4.29
Pain Relevance 11.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCY1) small molecule metabolic process (ADCY1) plasma membrane (ADCY1)
nucleus (ADCY1) GTPase activity (ADCY1) transmembrane transport (ADCY1)
Anatomy Link Frequency
embryonic kidney 6
nucleus accumbens 2
small intestine 2
ovary 2
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 49 100.00 Very High Very High Very High
opioid receptor 35 100.00 Very High Very High Very High
Dopamine 18 100.00 Very High Very High Very High
gABA 12 100.00 Very High Very High Very High
MU agonist 8 100.00 Very High Very High Very High
withdrawal 6 100.00 Very High Very High Very High
narcan 4 100.00 Very High Very High Very High
antagonist 31 99.98 Very High Very High Very High
Nucleus accumbens 5 99.84 Very High Very High Very High
noradrenaline 20 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 3 100.00 Very High Very High Very High
Bordatella Infection 32 99.96 Very High Very High Very High
INFLAMMATION 117 98.88 Very High Very High Very High
Infection 4 98.16 Very High Very High Very High
Vibrio Infection 2 88.52 High High
Skin Cancer 5 86.20 High High
Obesity 5 85.76 High High
Neuroblastoma 7 77.12 Quite High
Shock 5 75.00 Quite High
Attention Deficit Hyperactivity Disorder 1 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous study showed that opioid-induced adenylyl cyclase supersensitization in human embryonic kidney (HEK) 293 cells expressing the delta-opioid receptor requires G(i) but not G(z) proteins.
Positive_regulation (requires) of Positive_regulation (opioid-induced) of adenylyl cyclase in HEK associated with opioid receptor and opioid
1) Confidence 0.48 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991975 Disease Relevance 0.23 Pain Relevance 0.73
These studies showed that G(z) could mediate acute actions of mu- and kappa-opioids but G(z) alone was insufficient to mediate adenylyl cyclase supersensitization induced by the chronic activation of opioid receptors.
Positive_regulation (mediate) of Positive_regulation (induced) of adenylyl cyclase associated with opioid receptor and opioid
2) Confidence 0.48 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991975 Disease Relevance 0.15 Pain Relevance 0.88
Most, though not all, of the effects of catecholamines at beta-receptors are mediated through activation of adenyl cyclase and increases in cyclic AMP accumulation.
Positive_regulation (mediated) of Positive_regulation (activation) of adenyl cyclase associated with catecholamine
3) Confidence 0.41 Published 1984 Journal Drugs Section Abstract Doc Link 6098436 Disease Relevance 0.09 Pain Relevance 0.41
Opioid-induced adenylyl cyclase supersensitization in human embryonic kidney 293 cells requires pertussis toxin-sensitive G proteins other than G(i1) and G(i3).
Positive_regulation (requires) of Positive_regulation (induced) of adenylyl cyclase in embryonic kidney associated with bordatella infection and opioid
4) Confidence 0.36 Published 2001 Journal Neurosci. Lett. Section Title Doc Link 11166929 Disease Relevance 0.42 Pain Relevance 0.48
Therefore, beta gamma subunits liberated after activation of inhibitory receptors seem to indirectly cause an increase in activity of type VI adenylyl cyclase.
Spec (seem) Positive_regulation (cause) of Positive_regulation (increase) of cyclase
5) Confidence 0.32 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8622641 Disease Relevance 0 Pain Relevance 0.07
Role of extracellular signal-regulated kinases in opioid-induced adenylyl cyclase superactivation in human embryonic kidney 293 cells.
Positive_regulation (opioid-induced) of Positive_regulation (superactivation) of adenylyl cyclase in embryonic kidney associated with opioid
6) Confidence 0.28 Published 2001 Journal Neurosci. Lett. Section Title Doc Link 11720767 Disease Relevance 0 Pain Relevance 0.67
Chronic opioid treatment of the same cells has also been shown to induce adenylyl cyclase (AC) superactivation.
Positive_regulation (induce) of Positive_regulation (induce) of adenylyl cyclase associated with opioid
7) Confidence 0.28 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11720767 Disease Relevance 0 Pain Relevance 0.68
Chronic activation of opioid receptors in cultured mammalian cells is known to induce adenylyl cyclase (AC) supersensitization via the pertussis toxin-sensitive G(i/o) proteins.
Positive_regulation (induce) of Positive_regulation (supersensitization) of adenylyl cyclase associated with bordatella infection and opioid receptor
8) Confidence 0.26 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11166929 Disease Relevance 0.38 Pain Relevance 0.35
Converging protein kinase pathways mediate adenylyl cyclase superactivation upon chronic delta-opioid agonist treatment.
Positive_regulation (mediate) of Positive_regulation (superactivation) of adenylyl cyclase associated with mu agonist
9) Confidence 0.26 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12660310 Disease Relevance 0 Pain Relevance 0.73
In fact, stimulation of adenylyl cyclase activity by DA was increased in nucleus accumbens membranes from sensitized rats.
Positive_regulation (increased) of Positive_regulation (stimulation) of adenylyl cyclase in nucleus accumbens associated with nucleus accumbens and dopamine
10) Confidence 0.19 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7616430 Disease Relevance 0.07 Pain Relevance 0.68
Hsp90AB1 transcript and protein levels increased significantly during morphine treatment, and co-application of geldanamycin (0.1-10 nM) effectively suppressed the increase in forskolin-activated adenylate cyclase activation by 56%.
Positive_regulation (increase) of Positive_regulation (activation) of cyclase associated with morphine
11) Confidence 0.15 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20100459 Disease Relevance 0.29 Pain Relevance 0.58
Expression of alpha-transducin in Chinese hamster ovary cells stably transfected with the human delta-opioid receptor attenuates chronic opioid agonist-induced adenylyl cyclase superactivation.
Positive_regulation (superactivation) of Positive_regulation (agonist-induced) of adenylyl cyclase in ovary associated with mu agonist and opioid receptor
12) Confidence 0.14 Published 2001 Journal Mol. Pharmacol. Section Title Doc Link 11641436 Disease Relevance 0.06 Pain Relevance 0.32
Inhibition of forskolin-stimulated adenylyl cyclase and phospholipase C beta (PLC beta) activation was measured in each of these cell lines.
Positive_regulation (forskolin-stimulated) of Positive_regulation (activation) of adenylyl cyclase
13) Confidence 0.14 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641436 Disease Relevance 0 Pain Relevance 0.25
Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: role of G protein and adenylyl cyclase activation.
Positive_regulation (role) of Positive_regulation (activation) of adenylyl cyclase associated with opioid receptor
14) Confidence 0.14 Published 1996 Journal Mol. Pharmacol. Section Title Doc Link 8967989 Disease Relevance 0.20 Pain Relevance 0.68
Stable or transient expression of wild-type MC1R, but not of loss-of-function mutants, potently stimulates forskolin activation of adenylyl cyclase, a common feature of constitutively active Gs-coupled receptors.
Positive_regulation (stimulates) of Positive_regulation (activation) of cyclase associated with melanocortin 1 receptor
15) Confidence 0.05 Published 2004 Journal Pigment Cell Res. Section Abstract Doc Link 15250941 Disease Relevance 0.27 Pain Relevance 1.13
Isoproterenol might exert its facilitatory effect through the stimulation of presynaptic beta-adrenoceptors, activation of adenyl cyclase and consequent increase of the intraneuronal concentration of cAMP.
Positive_regulation (stimulation) of Positive_regulation (activation) of adenyl cyclase
16) Confidence 0.04 Published 1984 Journal Acta Physiol Pharmacol Latinoam Section Abstract Doc Link 6152372 Disease Relevance 0 Pain Relevance 0.29
Coincidently, after long-term DPDPE treatment, pertussis toxin treatment eliminated the antagonist naloxone-induced superactivation of adenylyl cyclase activity.
Positive_regulation (naloxone-induced) of Positive_regulation (superactivation) of adenylyl cyclase associated with bordatella infection, antagonist and narcan
17) Confidence 0.03 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16525132 Disease Relevance 0.64 Pain Relevance 0.53
As for the signal transduction pathways activated by various subtypes of P2Y receptors, P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11 receptors are coupled via Gq/11 proteins to stimulate phospholipase C, followed by increases in inositol phosphates and mobilization of Ca2+ from intracellular stores; in addition, the P2Y11 receptor mediates an increase in adenyl cyclase activity [84].
Positive_regulation (mediates) of Positive_regulation (increase) of adenyl cyclase
18) Confidence 0.02 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0.06 Pain Relevance 0.21
The A2BR is coupled to proteins leading to stimulation of adenylyl cyclase upon receptor activation [6].
Positive_regulation (leading) of Positive_regulation (stimulation) of adenylyl cyclase
19) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.24 Pain Relevance 0.11
In other studies, inflammation of the small intestine induced by Trichinella spiralis causes increased adenylyl cyclase activity of myenteric neurons 6-9 days after infection [63].
Positive_regulation (causes) of Positive_regulation (increased) of adenylyl cyclase in small intestine associated with inflammation and infection
20) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.00 Pain Relevance 0.39

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