INT40505

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 0
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CCKAR) endoplasmic reticulum (CCKAR) plasma membrane (CCKAR)
lysosome (CCKAR) cytoplasm (CCKAR) signal transducer activity (CCKAR)
Anatomy Link Frequency
longitudinal muscle 1
CCKAR (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 43 100.00 Very High Very High Very High
substance P 4 99.52 Very High Very High Very High
tetrodotoxin 5 93.64 High High
Enkephalin 3 93.04 High High
opioid receptor 3 91.60 High High
Serotonin 1 56.12 Quite High

|}

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Caveolar cholesterol increases the caveolar sequestration of CAV-3 and CCK-1R caused by their reduced recycling to the PM.
Positive_regulation (increases) of CCK-1R associated with cholecystokinin
1) Confidence 0.40 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.45
CAV-3 siRNA reduced CAV-3 protein expression, decreased CCK-8-induced contraction, and accumulated CCK-1R in the caveolae.
Positive_regulation (accumulated) of CCK-1R associated with cholecystokinin
2) Confidence 0.40 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.62
Pretreatment with cholesterol-rich liposomes inhibited the transfer of CCK-1R and of CAV-3 in the endosomes by blocking CAV-3 phosphorylation. 4-Amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (inhibitor of tyrosine kinase) reproduced these effects by blocking pCAV-3 formation, increasing CAV-3 and CCK-1R sequestration in the caveolae and impairing CCK-8-induced contraction.
Positive_regulation (increasing) of CCK-1R associated with cholecystokinin
3) Confidence 0.12 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.62
The results provide the electrophysiological basis for CCK-OP and pentagastrin induced changes in colonic motility.
Positive_regulation (induced) of CCK-OP
4) Confidence 0.10 Published 1984 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6099217 Disease Relevance 0 Pain Relevance 0.38
Evidence that the action of cholecystokinin octapeptide on the guinea pig ileum longitudinal muscle is mediated in part by substance P release from the myenteric plexus.
Positive_regulation (mediated) of cholecystokinin octapeptide in longitudinal muscle associated with cholecystokinin and substance p
5) Confidence 0.00 Published 1981 Journal Eur. J. Pharmacol. Section Title Doc Link 6162653 Disease Relevance 0 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox