INT40520

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Context Info
Confidence 0.30
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.51
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ikbkb) kinase activity (Ikbkb) cytoplasm (Ikbkb)
Ikbkb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 29 99.90 Very High Very High Very High
Inflammation 75 99.72 Very High Very High Very High
Opioid 2 98.88 Very High Very High Very High
Immobilon 1 97.64 Very High Very High Very High
Spinal cord 2 95.00 High High
Inflammatory mediators 1 94.48 High High
Bioavailability 4 94.32 High High
dexamethasone 2 92.36 High High
opioid receptor 1 92.32 High High
Potency 2 59.04 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 77 99.72 Very High Very High Very High
Colon Cancer 78 97.00 Very High Very High Very High
Pressure And Volume Under Development 5 86.56 High High
Rectal Cancer 69 82.72 Quite High
Disease 26 77.64 Quite High
Hypersensitivity 6 76.80 Quite High
Pneumonia 1 76.08 Quite High
Rheumatoid Arthritis 8 47.12 Quite Low
Colitis 1 17.36 Low Low
Arthritis 10 9.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compound 7 has been reported to be a potent, ATP-competitive, and moderately selective inhibitor of IKK2 with Ki?
Gene_expression (selective) of IKK2
1) Confidence 0.30 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.64 Pain Relevance 0.34
In terms of effect size, the odds ratios do not differ substantively from single SNP results although in logistic regression models adjusted for covariates, IKBKB rs3747811 and IL6 rs1800797 may mitigate increased risk of NFKB1.
Gene_expression (rs3747811) of IKBKB
2) Confidence 0.27 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC3006374 Disease Relevance 0.27 Pain Relevance 0.03
We applied the hapConstructor method to a multilocus investigation of candidate genes involved in pro-inflammatory cytokine IL6 production, IKBKB, IL6, and NFKB1 (16 SNPs total) hypothesized to operate together to alter colorectal cancer risk.
Gene_expression (production) of IKBKB associated with inflammation, colon cancer and cytokine
3) Confidence 0.24 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC3006374 Disease Relevance 0.59 Pain Relevance 0.14
Kappa 1 (kappa) and kappa 2 (benzomorphan) binding sites were individually detected by the overall labeling of opioid binding sites with [3H]-etorphine followed by the elimination of binding to particular sites by the use of appropriate selective unlabelled ligands.
Gene_expression (detected) of kappa 2 associated with opioid and immobilon
4) Confidence 0.20 Published 1984 Journal Neuropeptides Section Abstract Doc Link 6099476 Disease Relevance 0 Pain Relevance 0.35
A description of genotyped markers (in chromosome order) in IKBKB, IL6, and NFKB1 (including MAF and P-HWE) is shown in Additional file 1.
Gene_expression (including) of IKBKB
5) Confidence 0.12 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC3006374 Disease Relevance 0 Pain Relevance 0

General Comments

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