INT4053

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Context Info
Confidence 0.58
First Reported 1976
Last Reported 2010
Negated 3
Speculated 4
Reported most in Abstract
Documents 27
Total Number 33
Disease Relevance 5.57
Pain Relevance 13.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRP) extracellular space (GRP) extracellular region (GRP)
Anatomy Link Frequency
plasma 3
lungs 2
insular cortex 1
muscle 1
amygdala 1
GRP (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 36 100.00 Very High Very High Very High
Somatostatin 25 100.00 Very High Very High Very High
opiate 11 100.00 Very High Very High Very High
Enkephalin 31 99.96 Very High Very High Very High
Cholecystokinin 7 99.92 Very High Very High Very High
GABAergic 80 99.84 Very High Very High Very High
qutenza 4 99.82 Very High Very High Very High
Opioid 9 99.78 Very High Very High Very High
anesthesia 1 99.74 Very High Very High Very High
Anterior cingulate cortex 240 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 5 100.00 Very High Very High Very High
Spinal Cord Injury 67 99.56 Very High Very High Very High
Duodenal Ulcer 9 98.12 Very High Very High Very High
Pruritus 55 97.88 Very High Very High Very High
Pancreatitis 3 97.04 Very High Very High Very High
Bronchitis 4 96.84 Very High Very High Very High
Bardet-biedl Syndrome 4 96.20 Very High Very High Very High
Emphysema 4 95.92 Very High Very High Very High
Anxiety Disorder 40 93.24 High High
Lung Cancer 3 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We cannot completely rule out other possible modulation of GRP on excitatory transmission that cannot be revealed in the present studies.
Spec (possible) Regulation (modulation) of GRP
1) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0.21 Pain Relevance 0.86
Neither drug, nor the combination had any effect on plasma GRP following sham feeding.
Regulation (effect) of GRP in plasma
2) Confidence 0.54 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 3562904 Disease Relevance 0.17 Pain Relevance 0.38
Effects of gastrin-releasing peptide (GRP) on the mechanical activity of the human ileocaecal region in vitro.
Regulation (Effects) of gastrin-releasing peptide
3) Confidence 0.45 Published 1997 Journal Neurogastroenterol. Motil. Section Title Doc Link 9430795 Disease Relevance 0 Pain Relevance 0.08
Effects of gastrin-releasing peptide (GRP) on the mechanical activity of the human ileocaecal region in vitro.
Regulation (Effects) of GRP
4) Confidence 0.45 Published 1997 Journal Neurogastroenterol. Motil. Section Title Doc Link 9430795 Disease Relevance 0 Pain Relevance 0.08
The effects of the anticholinergic drug benzilonium bromide and the opiate receptor blocker naloxone, given alone or in combination, on the acid secretory response and on plasma gastrin releasing peptide (GRP) response to sham feeding was tested in eight duodenal ulcer (DU) patients.
Regulation (effects) of GRP in plasma associated with duodenal ulcer, narcan and opiate
5) Confidence 0.45 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 3562904 Disease Relevance 0.20 Pain Relevance 0.37
In these studies, we examined the effect of peripherally administered putative satiety substances, cholecystokininoctapeptide, somatostatin, bombesin, gastrin-releasing peptide, thyrotropin-releasing hormone, calcitonin and glucagon on butorphanol induced feeding.
Spec (examined) Regulation (effect) of gastrin-releasing peptide associated with butorphanol and somatostatin
6) Confidence 0.44 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6316370 Disease Relevance 0.08 Pain Relevance 0.80
Less information is available for the functional action for GRP in the prefrontal cortex including the anterior cingulate cortex (ACC).
Regulation (available) of GRP in prefrontal associated with anterior cingulate cortex
7) Confidence 0.43 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2945970 Disease Relevance 0.19 Pain Relevance 0.32
The effects of the anticholinergic drug benzilonium bromide and the opiate receptor blocker naloxone, given alone or in combination, on the acid secretory response and on plasma gastrin releasing peptide (GRP) response to sham feeding was tested in eight duodenal ulcer (DU) patients.
Regulation (effects) of gastrin releasing peptide in plasma associated with duodenal ulcer, narcan and opiate
8) Confidence 0.39 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 3562904 Disease Relevance 0.20 Pain Relevance 0.37
The influence of eledoisin and bombesin on release of prostaglandins was compared with that of bradykinin (Sametz and Juan 1982).
Regulation (influence) of bombesin associated with bradykinin
9) Confidence 0.35 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6088999 Disease Relevance 0 Pain Relevance 0.48
Pulmonary endocrine cells have been studied according to their immunoreactivity for neuron-specific enolase, gastrin-releasing peptide (GRP), calcitonin, leucine-enkephalin, and serotonin in the lungs of subjects with chronic bronchitis and emphysema.
Regulation (immunoreactivity) of gastrin-releasing peptide in lungs associated with emphysema, enkephalin, bronchitis and serotonin
10) Confidence 0.29 Published 1989 Journal J. Pathol. Section Abstract Doc Link 2921673 Disease Relevance 0.34 Pain Relevance 0.17
Pulmonary endocrine cells have been studied according to their immunoreactivity for neuron-specific enolase, gastrin-releasing peptide (GRP), calcitonin, leucine-enkephalin, and serotonin in the lungs of subjects with chronic bronchitis and emphysema.
Regulation (immunoreactivity) of GRP in lungs associated with emphysema, enkephalin, bronchitis and serotonin
11) Confidence 0.29 Published 1989 Journal J. Pathol. Section Abstract Doc Link 2921673 Disease Relevance 0.34 Pain Relevance 0.17
However, in contrast to its central nervous system (CNS) actions, this effect appears to be mediated through a non-opioid mechanism involving bombesin, an autocrine growth-stimulatory factor that plays a central role in the early events of pulmonary carcinogenesis.
Regulation (involving) of bombesin in central nervous system associated with central nervous system and opioid
12) Confidence 0.26 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10355747 Disease Relevance 0.89 Pain Relevance 0.76
In this overview, an introduction to the GPCRs and the field of central regulation of food intake is provided together with brief mentioning of some other GPCRs that are also implicated in regulation of body weight, such as the melanin-concentrating hormone (MCH), neuromedin U, prolactin-releasing peptide (PrRP), bombesin, cholecystokinin (CCK), Glucagon-like peptide-1 (GLP-1) (and oxyntomodulin), neuropeptide B (NPB) and neuropeptide W (NPW), opioids peptides, free fatty acid (FFA) receptors (GPR40, GPR41).
Regulation (regulation) of bombesin in body associated with body weight, neuropeptide, opioid and cholecystokinin
13) Confidence 0.26 Published 2006 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 16787226 Disease Relevance 0.32 Pain Relevance 0.37
The maximum GRP, GRP 20-27, and CCK-8 responses were 54.2 +/- 4.2%, 74.6 +/- 6.4%, and 69.3 +/- 6.9% of that of carbachol, respectively.
Regulation (responses) of GRP
14) Confidence 0.26 Published 1997 Journal Peptides Section Abstract Doc Link 9357068 Disease Relevance 0.18 Pain Relevance 0.41
The maximum GRP, GRP 20-27, and CCK-8 responses were 54.2 +/- 4.2%, 74.6 +/- 6.4%, and 69.3 +/- 6.9% of that of carbachol, respectively.
Regulation (responses) of GRP
15) Confidence 0.26 Published 1997 Journal Peptides Section Abstract Doc Link 9357068 Disease Relevance 0.18 Pain Relevance 0.41
Future studies are required to address whether the modulation of GRP in the ACC inhibitory circuit would contribution to itch sensation.
Spec (whether) Regulation (modulation) of GRP associated with pruritus and anterior cingulate cortex
16) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0.97 Pain Relevance 0.64
Similar results on GRP modulation of GABAergic transmission were observed in the insular cortex and amygdala, suggesting a general possible effect of GRP on cortical inhibitory transmission.
Regulation (modulation) of GRP in amygdala associated with gabaergic and amygdala
17) Confidence 0.26 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2945970 Disease Relevance 0.13 Pain Relevance 0.42
Effect of bombesin, a natural tetradecapeptide, on myoelectrical and mechanical activity of isolated, ex vivo perfused, canine stomach.
Regulation (Effect) of bombesin in stomach
18) Confidence 0.23 Published 1976 Journal Pharmacology Section Title Doc Link 959311 Disease Relevance 0 Pain Relevance 0.07
GRP-induced contractions were unaffected by muscarinic antagonism (1 microM atropine), axonal blockade (1 microM tetrodotoxin), cholecystokinin (CCK) receptor antagonism (10 microM MK-329), or substance P desensitization (1 microM), supporting the existence of myogenic GRP receptors.
Neg (unaffected) Regulation (unaffected) of GRP associated with tetrodotoxin, cholecystokinin and substance p
19) Confidence 0.21 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1708207 Disease Relevance 0 Pain Relevance 0.27
GRP immunoreactivity was detected in 46 and 38% of the DiI-labelled muscle and mucosa neurones, respectively.
Regulation (immunoreactivity) of GRP in muscle
20) Confidence 0.20 Published 2000 Journal J. Chem. Neuroanat. Section Abstract Doc Link 10936745 Disease Relevance 0 Pain Relevance 0.90

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