INT40565

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Context Info
Confidence 0.75
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 7.25
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SLPI) enzyme binding (SLPI)
Anatomy Link Frequency
leukocyte 2
plasma 1
liver 1
parathyroid 1
SLPI (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 54 100.00 Very High Very High Very High
backache 10 93.84 High High
Pain 51 93.20 High High
cytokine 7 89.08 High High
Lasting pain 20 85.56 High High
cINOD 5 80.24 Quite High
ischemia 94 75.60 Quite High
Inflammation 9 75.28 Quite High
Chronic pancreatitis 2 74.16 Quite High
Myofascial pain syndrome 8 60.40 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 6 98.86 Very High Very High Very High
Bacterial Vaginosis 23 98.68 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

2 98.42 Very High Very High Very High
Enteropathy 1 98.32 Very High Very High Very High
Ovarian Cancer 122 98.00 Very High Very High Very High
Pathologic Constriction 164 95.68 Very High Very High Very High
Pancreatic Cancer 2 94.96 High High
Low Back Pain 12 93.84 High High
Pain 71 93.20 High High
Syndrome 6 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pancreatic juice GGT, alanine transaminase (ALT, EC 2.6.1.2), and alkaline phosphatase (ALP, EC 3.1.3.1) were measured and found to be present in all samples.
Gene_expression (present) of ALP
1) Confidence 0.75 Published 1980 Journal Dig. Dis. Sci. Section Abstract Doc Link 6102899 Disease Relevance 0.56 Pain Relevance 0.07
Serum type I collagen C-telopeptide (sCTX), urinary free-deoxypyridinoline (ufDPD), bone alkaline phosphatase (ALP) and serum osteocalcin levels were determined.
Gene_expression (levels) of ALP
2) Confidence 0.75 Published 2005 Journal J. Endocrinol. Invest. Section Abstract Doc Link 15952402 Disease Relevance 0.49 Pain Relevance 0.06
METHODS: We prospectively evaluated the levels of the serum concentration of liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), and total bilirubin (TBil), in 42 morbidly obese and 40 non obese patients who were scheduled for elective abdominal surgery under sevoflurane anesthesia at the Jordan University Hospital, Amman, Jordan.
Gene_expression (phosphatase) of ALP in liver
3) Confidence 0.65 Published 2009 Journal Middle East J Anesthesiol Section Body Doc Link 19583067 Disease Relevance 0.18 Pain Relevance 0
Serum osteocalcin, total and bone alkaline phosphatase (ALP, BALP, respectively), 25-hydroxyvitamin D (25-OHD), parathyroid hormone (PTH), urinary deoxypyridinoline (Dpyr), and pyridinoline (Pyr) were measured in the patients with AS and compared with 52 age and sex matched controls.
Gene_expression (measured) of ALP in parathyroid
4) Confidence 0.65 Published 1999 Journal J. Rheumatol. Section Body Doc Link 10529140 Disease Relevance 0.16 Pain Relevance 0
We also observed dyslipidemia and expected high HDL-c levels in C57BL/6 mice [22], with altered high plasma levels of ALT, AST and ALK.
Gene_expression (levels) of ALK in plasma associated with disorder of lipid metabolism
5) Confidence 0.58 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 0.58 Pain Relevance 0.07
METHODS: Serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBil), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GTP), and lactate dehydrogenase (LDH) were measured before and 1,2,3,7, and 14 days after anesthesia in each of 60 patients receiving either sevoflurane or isoflurane anesthesia for neurosurgery (tumor resection).
Gene_expression (levels) of ALP
6) Confidence 0.58 Published 1999 Journal Acta Anaesthesiol Scand Section Body Doc Link 10081544 Disease Relevance 0 Pain Relevance 0
The results show that BV CVF samples are deficient in antimicrobial activity due to lower expression levels of several antimicrobial peptides such as SLPI, defensins, lysozyme and lactoferrin [142-147].
Gene_expression (expression) of SLPI associated with bacterial vaginosis
7) Confidence 0.48 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3016264 Disease Relevance 1.05 Pain Relevance 0.13
The quality of SPECT-MPI images in five of these patients was suboptimal from motion or breast attenuation artifact and they were unable to undergo prone imaging.
Gene_expression (images) of SPECT-MPI associated with imagery
8) Confidence 0.11 Published 2010 Journal J Nucl Cardiol Section Body Doc Link PMC2940027 Disease Relevance 1.31 Pain Relevance 0.33
Exploratory and confirmatory factor analyses were used in determining the specific scales for the sections of the MPI.
Gene_expression (sections) of MPI
9) Confidence 0.09 Published 2006 Journal Head Face Med Section Body Doc Link PMC1764727 Disease Relevance 1.40 Pain Relevance 1.15
Development of the Spanish MPI version
Gene_expression (version) of MPI
10) Confidence 0.09 Published 2006 Journal Head Face Med Section Body Doc Link PMC1764727 Disease Relevance 0.19 Pain Relevance 0.11
Many of the markers expressed in other subtypes were either infrequently (<10%) expressed (p53, ER, PAX8, SLPI, K-Cadherin, and CA125), or completely absent (CRABP2, WT-1, and Mesothelin).
Neg (absent) Gene_expression (expressed) of SLPI
11) Confidence 0.08 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2592352 Disease Relevance 0.29 Pain Relevance 0
In this retrospective study we assessed the protein expression of 21 candidate tissue-based biomarkers (CA125, CRABP-II, EpCam, ER, F-Spondin, HE4, IGF2, K-Cadherin, Ki-67, KISS1, Matriptase, Mesothelin, MIF, MMP7, p21, p53, PAX8, PR, SLPI, TROP2, WT1) in a population-based cohort of 500 ovarian carcinomas that was collected over the period from 1984 to 2000.
Gene_expression (expression) of SLPI associated with ovarian cancer
12) Confidence 0.08 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2592352 Disease Relevance 0.55 Pain Relevance 0
The intake of aspirin by patients infected with H. pylori was associated with marked rise in the expression of HD5 and less expression of secretory leukocyte protease inhibitor.
Gene_expression (expression) of leukocyte protease in leukocyte
13) Confidence 0.05 Published 2005 Journal Dig Liver Dis Section Body Doc Link 15702860 Disease Relevance 0 Pain Relevance 0
BACKGROUND: Fecal alpha(1)-proteinase inhibitor (alpha(1)-PI) clearance is a reliable, noninvasive marker for protein-losing enteropathy (PLE) in human beings.
Gene_expression (clearance) of proteinase inhibitor associated with enteropathy
14) Confidence 0.05 Published 2003 Journal Vet Clin Pathol Section Abstract Doc Link 12966464 Disease Relevance 0.39 Pain Relevance 0.29
METHODS: We assessed the expression of epithelial secretory leukocyte protease inhibitor, human beta-defensins (HBD1 and HBD2), and alpha-defensin (HD5) in gastric biopsies taken from 52 patients, median age of 55 years.
Gene_expression (expression) of leukocyte protease in leukocyte
15) Confidence 0.04 Published 2005 Journal Dig Liver Dis Section Body Doc Link 15702860 Disease Relevance 0 Pain Relevance 0

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