INT4060

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 5.23
Pain Relevance 6.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Bche) endoplasmic reticulum (Bche)
Anatomy Link Frequency
brain 2
blood 1
spinal 1
Plasma 1
tail 1
Bche (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 3 100.00 Very High Very High Very High
analgesia 14 99.96 Very High Very High Very High
intrathecal 16 99.84 Very High Very High Very High
Clonidine 29 99.04 Very High Very High Very High
Morphine 8 98.56 Very High Very High Very High
Neurotransmitter 8 97.48 Very High Very High Very High
Opioid 4 97.28 Very High Very High Very High
agonist 6 96.56 Very High Very High Very High
headache 3 95.44 Very High Very High Very High
cerebral cortex 9 95.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 10 99.98 Very High Very High Very High
Congenital Anomalies 3 99.98 Very High Very High Very High
Cognitive Disorder 49 99.68 Very High Very High Very High
Drug Induced Neurotoxicity 6 99.06 Very High Very High Very High
Fatigue 3 98.96 Very High Very High Very High
Hepatotoxicity 4 98.70 Very High Very High Very High
Anxiety Disorder 1 97.04 Very High Very High Very High
Vomiting 12 96.84 Very High Very High Very High
Alzheimer's Dementia 9 95.92 Very High Very High Very High
Dizziness 2 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These included: physostigmine (PHY), heptyl-physostigmine (HEP) and 2,2-dichloro-vinyldimethyl phosphate (DDVP), at concentrations producing cholinesterase (ChE) inhibition ranging from 5% to 95%.
Gene_expression (producing) of cholinesterase
1) Confidence 0.70 Published 1995 Journal Neuroreport Section Abstract Doc Link 7605915 Disease Relevance 0.15 Pain Relevance 0.08
Protection afforded by clonidine from the acute and chronic behavioral toxicity produced by the cholinesterase inhibitor soman.
Gene_expression (produced) of cholinesterase associated with toxicity and clonidine
2) Confidence 0.68 Published 1989 Journal Neurotoxicol Teratol Section Title Doc Link 2725439 Disease Relevance 0.32 Pain Relevance 0.67
The three cholinesterase inhibitors produced profound analgesia on hot plate testing but incomplete analgesia using the tail immersion test.
Gene_expression (produced) of cholinesterase in tail associated with analgesia
3) Confidence 0.68 Published 1995 Journal Anesth. Analg. Section Abstract Doc Link 7653812 Disease Relevance 0 Pain Relevance 1.72
Long-term behavioral and learning abnormalities produced by the irreversible cholinesterase inhibitor soman: effect of a standard pretreatment regimen and clonidine.
Gene_expression (produced) of cholinesterase associated with congenital anomalies and clonidine
4) Confidence 0.67 Published 1990 Journal Toxicol. Lett. Section Title Doc Link 2389260 Disease Relevance 0.27 Pain Relevance 0.38
These included physostigmine (PHY), heptyl-physostigmine (HEP) and 2,2-dichlorovinyldimethyl phosphate (DDVP), at the concentrations producing cholinesterase (ChE) inhibition ranging from 5% to 95%.
Gene_expression (producing) of cholinesterase
5) Confidence 0.65 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8624119 Disease Relevance 0.15 Pain Relevance 0.08
By introduction of silent or non sense gene as in atypical cholinesterase, a given function was not operated.
Gene_expression (introduction) of cholinesterase
6) Confidence 0.65 Published 2009 Journal Masui Section Abstract Doc Link 19764429 Disease Relevance 0.22 Pain Relevance 0.43
We (1) characterized the cholinergic receptor system through which intrathecally applied cholinesterase inhibitors produce their antinociceptive effect and (2) examined their interaction with spinal mu opioid and alpha 2-adrenergic receptors.
Gene_expression (produce) of cholinesterase in spinal associated with opioid and antinociceptive
7) Confidence 0.64 Published 1994 Journal Anesthesiology Section Abstract Doc Link 8010479 Disease Relevance 0 Pain Relevance 0.23
Thus, marked reduction in the levels of brain ChE is not the only factor involved in the production of mAChR downregulation to cholinesterase inhibitors.
Gene_expression (production) of cholinesterase in brain
8) Confidence 0.62 Published 1993 Journal Brain Res. Bull. Section Abstract Doc Link 8221166 Disease Relevance 0 Pain Relevance 0.21
Intrathecal acetyl cholinesterase inhibitors produce analgesia that is synergistic with morphine and clonidine in rats.
Gene_expression (produce) of cholinesterase associated with clonidine, morphine, analgesia and intrathecal
9) Confidence 0.59 Published 1995 Journal Anesth. Analg. Section Title Doc Link 7653812 Disease Relevance 0 Pain Relevance 1.57
Differential expressions of the marker genes for hepatotoxicity and neurotoxicity were detectable in the blood earlier than the appearance of the commonly used clinical markers (serum transaminases and acetyl cholinesterase).
Gene_expression (appearance) of acetyl cholinesterase in blood associated with drug induced neurotoxicity and hepatotoxicity
10) Confidence 0.55 Published 2010 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19784758 Disease Relevance 0.86 Pain Relevance 0.31
For dosages of 2, 6, 10, and 12 mg/day mean AChE inhibition was 20%, 46%, 55.6%, and 61.7%, whereas BChE inhibition was 23.9%, 76.6%, 54.9%, and 61%, although wide variability among patients was observed for the BChE values.


Gene_expression (values) of BChE
11) Confidence 0.54 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684084 Disease Relevance 0 Pain Relevance 0.10
Significantly depressed cholinesterase activities were found in the farm workers, with 10.5% of the farm workers having values below the lower limit of normal.
Gene_expression (found) of cholinesterase
12) Confidence 0.49 Published 1976 Journal Sci. Total Environ. Section Abstract Doc Link 959812 Disease Relevance 0.39 Pain Relevance 0.10
Plasma cholinesterase changes during the puerperium.
Gene_expression (changes) of cholinesterase in Plasma
13) Confidence 0.27 Published 1986 Journal Anaesthesia Section Title Doc Link 3963327 Disease Relevance 0.16 Pain Relevance 0.28
Finally, other cholinesterase activities present in the brain such as BuChE may also contribute to ACh hydrolysis.
Gene_expression (present) of cholinesterase in brain
14) Confidence 0.24 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.24 Pain Relevance 0
The deficiency of acetylcholine can be partially remedied by cholinesterase inhibitors that produce modest cognitive and behavioral improvement.
Gene_expression (produce) of cholinesterase associated with cognitive disorder
15) Confidence 0.23 Published 1997 Journal Conn Med Section Abstract Doc Link 9334509 Disease Relevance 1.70 Pain Relevance 0.24
There was no change in their neurological status, and serum acetylcholinesterase and butyrylcholinesterase levels were raised significantly, whereas the other serum enzymes showed no significant change.
Gene_expression (raised) of butyrylcholinesterase
16) Confidence 0.13 Published 1985 Journal Toxicol. Lett. Section Abstract Doc Link 3983971 Disease Relevance 0.17 Pain Relevance 0.13
No correlation was found between levels of cholinesterase and type or severity of complaints.
Gene_expression (levels) of cholinesterase
17) Confidence 0.06 Published 1991 Journal Isr. J. Med. Sci. Section Abstract Doc Link 1757241 Disease Relevance 0.61 Pain Relevance 0.09

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