INT40609

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Context Info
Confidence 0.36
First Reported 1980
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 3.42
Pain Relevance 9.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca) Golgi apparatus (Prkaca) plasma membrane (Prkaca)
nucleus (Prkaca) protein complex (Prkaca) kinase activity (Prkaca)
Anatomy Link Frequency
plasma 1
sensory neurons 1
hippocampus 1
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 225 100.00 Very High Very High Very High
Kinase C 89 100.00 Very High Very High Very High
opiate 5 100.00 Very High Very High Very High
Opioid 43 99.56 Very High Very High Very High
Morphine 127 99.20 Very High Very High Very High
Inflammation 143 98.98 Very High Very High Very High
qutenza 186 98.50 Very High Very High Very High
potassium channel 10 98.48 Very High Very High Very High
Hippocampus 13 97.48 Very High Very High Very High
Dopamine 489 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 156 98.98 Very High Very High Very High
Depression 50 96.16 Very High Very High Very High
Obesity 54 94.24 High High
Hyperalgesia 42 93.04 High High
Apoptosis 126 89.32 High High
Convulsion 2 86.72 High High
Ganglion Cysts 45 86.64 High High
Pulmonary Disease 31 84.40 Quite High
Anxiety Disorder 15 84.36 Quite High
Stress 12 83.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study aimed at determining the interaction between the PKC and PKA inhibitors and the morphine released "solely" from the pellet to reinstate the morphine-induced behavioral and physiological effects, 72h after implantation of morphine pellets.
PKA Binding (interaction) of associated with kinase c and morphine
1) Confidence 0.36 Published 2006 Journal Pharmacol. Res. Section Abstract Doc Link 17056270 Disease Relevance 0.13 Pain Relevance 1.67
AC produces the second messenger cyclic AMP, which can bind to the protein kinase A (PKA) regulatory subunit (Hanoune and Defer, 2001).
PKA Binding (bind) of
2) Confidence 0.25 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.05 Pain Relevance 0.34
These findings indicate that PDE4D controls the access of cAMP to PKA localized with the ?
PKA Binding (access) of
3) Confidence 0.21 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.09
cAMP binds to and activates PKA by binding to the regulatory subunit of PKA, releasing two catalytic subunits (PKAc).
PKA Binding (binding) of
4) Confidence 0.20 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.14
cAMP binds to and activates PKA by binding to the regulatory subunit of PKA, releasing two catalytic subunits (PKAc).
PKA Binding (binds) of
5) Confidence 0.19 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.13
Thus these two forms of bound PKA act as a sink for free PKAc, dampening the stimulatory effect of dopamine on the increase in the free PKAc levels.
PKA Binding (bound) of associated with dopamine
6) Confidence 0.19 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.16
In contrast, due to the much lower affinity of phosphoThr75 for PKA as well as the higher amount of phosphoThr75 in the system (basal level 13 ?
PKA Binding (affinity) of
7) Confidence 0.19 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0
Adenylyl cyclase activity increases cAMP, which then binds to PKA.
PKA Binding (binds) of
8) Confidence 0.18 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.26 Pain Relevance 0.34
Presynaptically, cAMP and cAMP-dependent protein kinase A (PKA) could target to presynaptic ion channels, such as potassium channels and the hyperpolarization-activated cation channel, or to presynaptic exocytosis machinery [14-16].
PKA Binding (target) of associated with potassium channel
9) Confidence 0.17 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.24 Pain Relevance 0.56
There has been extensive work demonstrating the activation of a PKA-dependent pathway by PGE2 that influences capsaicin- or heat-mediated actions in rat sensory neurons [20-22,37,38] as well as interactions between cloned TRPV1 and PKA [26,39-42].
PKA Binding (interactions) of in sensory neurons associated with qutenza
10) Confidence 0.14 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.59 Pain Relevance 0.44
In the normeperidine series, there was no apparent direct relationship between pKa and opiate receptor binding.
pKa Binding (binding) of associated with opiate
11) Confidence 0.10 Published 1980 Journal J. Med. Chem. Section Abstract Doc Link 6106064 Disease Relevance 0.09 Pain Relevance 0.80
The resulting cAMP levels influence the activity of PKA that in its activated state catalyzes phosphorylation of DARPP-32, a strong inhibitor of PP-1.
PKA Binding (activity) of
12) Confidence 0.09 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0
Our results present a novel molecular basis for the anti-inflammatory action of peripheral opioids through a functional interaction of the MOP and PKA-sensitized TRPV1.
PKA-sensitized Binding (interaction) of associated with inflammation, opioid receptor and opioid
13) Confidence 0.08 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 0.62 Pain Relevance 1.60
Indeed, ICC express PKA, PKC?
PKA Binding (Indeed) of
14) Confidence 0.08 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1779949 Disease Relevance 0 Pain Relevance 0.34
As the MOP is coupled negatively to adenylate cyclase and thus indirectly to PKA [18,51], direct activation of PKA and thus potentiation of capsaicin responses would negate the inhibitory effect of opioids on adenylate cyclase.
PKA Binding (indirectly) of associated with qutenza, opioid receptor and opioid
15) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 0.27 Pain Relevance 1.75
The kinase activated by BDNF is not known, but a candidate is protein kinase A (PKA), which can be transiently activated by BDNF signaling in the hippocampus [116].
PKA Binding (known) of in hippocampus associated with hippocampus
16) Confidence 0.07 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.23
Thus, estrogen binds to a specific receptor that activates PKA to rapidly uncouple the mu-opioid receptor from its K+ channel.
PKA Binding (binds) of associated with opioid receptor
17) Confidence 0.04 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9106625 Disease Relevance 0 Pain Relevance 0.40
Regulated exon 21 encodes a peptide cassette that modulates a variety of activities of the protein, including trafficking from the ER to the plasma membrane, phosphorylation by protein kinase C (PKC) and protein kinase A (PKA), interactions with yotiao, neurofilament L, and calmodulin, and activation of NMDAR-induced gene expression [3–7].
PKA Binding (interactions) of in plasma associated with kinase c
18) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0 Pain Relevance 0.08
Results showed that all treatment groups resulted in equal binding of Par4 to PKA (Figure 1E).
PKA Binding (binding) of
19) Confidence 0.03 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.19 Pain Relevance 0
Par-4 was immunoprecipitated and Western blot analysis on the immunoprecipitates was performed with PKA, NF?
PKA Binding (performed) of
20) Confidence 0.03 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.26 Pain Relevance 0

General Comments

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