INT40620

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Context Info
Confidence 0.45
First Reported 1976
Last Reported 1997
Negated 3
Speculated 2
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 2.45
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
ganglia 5
brain 4
neurons 2
sympathetic 2
adrenal medulla 2
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 8 100.00 Very High Very High Very High
Dopamine 14 99.88 Very High Very High Very High
Neuropeptide 28 99.70 Very High Very High Very High
Ventral tegmentum 10 99.64 Very High Very High Very High
Clonidine 2 99.06 Very High Very High Very High
agonist 4 98.86 Very High Very High Very High
Enkephalin 8 98.28 Very High Very High Very High
tetrodotoxin 3 98.20 Very High Very High Very High
cocaine 5 97.98 Very High Very High Very High
Morphine 11 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 16 100.00 Very High Very High Very High
Middle Cerebral Artery Infarction 6 96.16 Very High Very High Very High
Stroke 8 93.00 High High
Hypoxia 1 83.28 Quite High
Urological Neuroanatomy 2 79.56 Quite High
Injury 2 76.56 Quite High
Toxicity 1 73.60 Quite High
Infarction 2 62.76 Quite High
Ganglion Cysts 1 62.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of dopamine, chlorisondamine and tetrodotoxin on the carbachol-induced 22Na uptake into superior cervical ganglia are similar to their effects on carbachol-mediated induction of tyrosine hydroxylase in superior cervical ganglia kept in tissue culture (Thoenen and Otten 1977b).
Regulation (effects) of in ganglia Positive_regulation (induction) of tyrosine hydroxylase in superior associated with tetrodotoxin and dopamine
1) Confidence 0.45 Published 1980 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6107866 Disease Relevance 0.06 Pain Relevance 0.34
We conclude that local cortical neurons are responsible for the increase in neuropeptide Y in the periinfarct region, that the cortical increase in tyrosine hydroxylase is not dependent on fast axonal transport, and that axonal transport of signals from the insular cortex to the amygdala is critical in mediating the amygdalar neuropeptide changes seen after stroke.
Neg (not) Regulation (dependent) of Positive_regulation (increase) of tyrosine hydroxylase in neurons associated with stroke, neuropeptide and amygdala
2) Confidence 0.44 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9331169 Disease Relevance 0.51 Pain Relevance 0.52
Here we examined the effect of immobilization stress and treatment with ACTH and glucocorticoids on messenger RNA (mRNA) levels for tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), preproneuropeptide Y (pre-NPY), and proenkephalin in rat superior cervical ganglia (SCG) and in stellate ganglia.
Spec (examined) Regulation (effect) of Positive_regulation (levels) of TH in ganglia associated with stress and dopamine
3) Confidence 0.40 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.47 Pain Relevance 0.27
Here we examined the effect of immobilization stress and treatment with ACTH and glucocorticoids on messenger RNA (mRNA) levels for tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), preproneuropeptide Y (pre-NPY), and proenkephalin in rat superior cervical ganglia (SCG) and in stellate ganglia.
Spec (examined) Regulation (effect) of Positive_regulation (levels) of tyrosine hydroxylase in ganglia associated with stress and dopamine
4) Confidence 0.40 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.47 Pain Relevance 0.27
Together, these findings support a scheme whereby chronic, systemic administration of morphine or cocaine leads to a sustained increase in ERK phosphorylation state and activity in the VTA, which, in turn, contributes to drug-induced increases in TH, and perhaps other drug-induced adaptations, elicited selectively in this brain region.
Regulation (contributes) of Positive_regulation (increases) of TH in brain associated with ventral tegmentum, cocaine and morphine
5) Confidence 0.34 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8764658 Disease Relevance 0.07 Pain Relevance 0.92
Thus, the birth-related increases in TH, DBH, NPY, and ENK mRNA levels in the rat adrenal medulla are dependent on postnatal oxygenation.
Regulation (dependent) of Positive_regulation (increases) of TH in adrenal medulla associated with medulla
6) Confidence 0.32 Published 1995 Journal Pediatr. Res. Section Abstract Doc Link 7651752 Disease Relevance 0.08 Pain Relevance 0.40
Injection of colchicine enhanced the periinfarct increase in neuropeptide Y but did not alter the increase in tyrosine hydroxylase.
Neg (not) Regulation (alter) of Positive_regulation (increase) of tyrosine hydroxylase associated with neuropeptide
7) Confidence 0.26 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9331169 Disease Relevance 0.62 Pain Relevance 0.64
Role of membrane depolarization in transsynaptic induction of tyrosine hydroxylase in organ cultures of sympathetic ganglia.
Regulation (Role) of Positive_regulation (induction) of tyrosine hydroxylase in sympathetic
8) Confidence 0.24 Published 1976 Journal Neurosci. Lett. Section Title Doc Link 19604822 Disease Relevance 0 Pain Relevance 0.34
The results bring into question the concept that brain Tyr is an important additional factor controlling catechol synthesis during increased tyrosine hydroxylase activity.
Regulation (controlling) of Positive_regulation (increased) of tyrosine hydroxylase in brain
9) Confidence 0.18 Published 1983 Journal J. Neurochem. Section Abstract Doc Link 6827272 Disease Relevance 0.15 Pain Relevance 0.42
The presence of the beta-blocker propranolol (0.1 microM), alpha-blockers phentolamine (0.31 microM) or yohimbine (0.3 microM) or the alpha-agonist clonidine (0.1 microM) in the incubation medium did not affect tyrosine hydroxylase activation by 50 mM K+.
Neg (not) Regulation (affect) of Neg (not) Positive_regulation (activation) of tyrosine hydroxylase associated with beta blocker, agonist and clonidine
10) Confidence 0.16 Published 1984 Journal Acta Physiol Pharmacol Latinoam Section Abstract Doc Link 6152372 Disease Relevance 0 Pain Relevance 0.28
Presynaptic adrenoceptors on the regulation of tyrosine hydroxylase activation by potassium.
Regulation (regulation) of Positive_regulation (activation) of tyrosine hydroxylase
11) Confidence 0.16 Published 1984 Journal Acta Physiol Pharmacol Latinoam Section Title Doc Link 6152372 Disease Relevance 0 Pain Relevance 0.28

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