INT40638

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 5.81
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (HRH1) plasma membrane (HRH1) nucleus (HRH1)
cytoplasm (HRH1) signal transducer activity (HRH1)
HRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 296 100.00 Very High Very High Very High
Antihistamine 42 100.00 Very High Very High Very High
antagonist 38 100.00 Very High Very High Very High
Opioid 4 99.36 Very High Very High Very High
Dopamine 3 99.20 Very High Very High Very High
Morphine 11 99.18 Very High Very High Very High
opiate 4 98.20 Very High Very High Very High
gABA 1 97.88 Very High Very High Very High
Serotonin 26 95.76 Very High Very High Very High
alcohol 5 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 9 99.20 Very High Very High Very High
Anxiety Disorder 3 98.20 Very High Very High Very High
Sleep Disorders 4 97.96 Very High Very High Very High
Hypoglycemia 172 97.16 Very High Very High Very High
Syndrome 23 96.64 Very High Very High Very High
Hallucination 1 95.92 Very High Very High Very High
Pulmonary Disease 22 93.28 High High
Asthma 47 92.92 High High
Body Weight 4 91.40 High High
Fungal Infection 1 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It can be concluded that the histamine system is involved in anxiety-like behavior, and repeated injections of morphine followed by five days free of the drugs interact with histamine receptor mechanism.
histamine receptor Binding (interact) of associated with anxiety disorder and morphine
1) Confidence 0.44 Published 2010 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 20093321 Disease Relevance 0.10 Pain Relevance 0.58
These results indicate that histamine H1 receptor antagonists such as mepyramine are potent inhibitors of P450 2D forms because of their high affinity for these enzymes.
histamine H1 receptor Binding (affinity) of associated with antagonist
2) Confidence 0.31 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7853212 Disease Relevance 0 Pain Relevance 0.23
The association of hyperglycaemia was most pronounced for antidepressants with corresponding binding properties for the 5-HT2c receptor, H1 receptor and NE reuptake transporter.
H1 receptor Binding (association) of associated with antidepressant
3) Confidence 0.21 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2668653 Disease Relevance 0.99 Pain Relevance 0.63
The association of hyperglycaemia was most pronounced for antidepressants with corresponding binding properties for the 5-HT2c receptor, H1 receptor and NE reuptake transporter.
H1 receptor Binding (binding) of associated with antidepressant
4) Confidence 0.21 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2668653 Disease Relevance 0.93 Pain Relevance 0.61
The association between antidepressant use and hyperglycaemia was most pronounced for antidepressants with high affinity for the NE reuptake transporter, 5-HT2c receptor and H1 receptor.
H1 receptor Binding (affinity) of associated with antidepressant
5) Confidence 0.21 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2668653 Disease Relevance 0.43 Pain Relevance 0.47
We found that the association between hyperglycaemia and use of antidepressants was most pronounced for antidepressants from cluster 2 and cluster 3 with corresponding binding properties for the NE reuptake transporter, 5-HT2c receptor and H1 receptor.
H1 receptor Binding (binding) of associated with antidepressant
6) Confidence 0.21 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2668653 Disease Relevance 0.78 Pain Relevance 0.33
DMH is an H(1) histamine receptor antagonist, but it interacts either directly or indirectly with other neurotransimitter systems, including those using acetylcholine, serotonin, norepinephrine, dopamine, opioids or adenosine.
histamine receptor Binding (interacts) of associated with adenocard, dopamine, antagonist, opioid and serotonin
7) Confidence 0.15 Published 2002 Journal Neurosci Biobehav Rev Section Abstract Doc Link 11835984 Disease Relevance 0.28 Pain Relevance 0.29
Other studies have shown that combining an H1 receptor blocker with an H2 receptor blocker such as cimetidine may help to prevent or reduce the risk of red man syndrome [5].
H1 receptor Binding (blocker) of associated with syndrome
8) Confidence 0.12 Published 2003 Journal Crit Care Section Body Doc Link PMC270616 Disease Relevance 1.05 Pain Relevance 0.31
The interaction of antihistamine with CNS receptors other than histamine receptor may explain, at least in part, the side effect of sedation.
histamine receptor Binding (interaction) of associated with antihistamine and sleep disorders
9) Confidence 0.11 Published 1981 Journal J. Lab. Clin. Med. Section Abstract Doc Link 6108979 Disease Relevance 0.18 Pain Relevance 0.41
This carboxylic acid then binds to the H1 histamine receptor and should relieve allergy symptoms.
H1 histamine receptor Binding (binds) of associated with hypersensitivity
10) Confidence 0.03 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2584094 Disease Relevance 0.25 Pain Relevance 0.14
These conditions are most likely never met for binding of antihistamines with the histamine receptor due to the transient nature of the response in comparison to the slow off rate for unbinding of antihistamines such as desloratadine [18].
histamine receptor Binding (binding) of associated with antihistamine
11) Confidence 0.01 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1079883 Disease Relevance 0 Pain Relevance 0.32
The present study investigated the effect of interactions between histamine receptor agents and the opioid peptidergic system on memory retention of passive avoidance learning in rats.
histamine receptor Binding (interactions) of associated with opioid
12) Confidence 0.01 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12354569 Disease Relevance 0 Pain Relevance 0.46
We also demonstrated that this phenomenon is very likely receptor mediated, since ascorbate binds to the histamine receptor with a Kd equal to its ability to enhance histamine activity [4].
histamine receptor Binding (binds) of
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0.46 Pain Relevance 0.11
In light of the receptor mechanism suggested above for Asc enhancement of adrenergic function, and since Asc modifies dopamine binding to its receptors [1], [18] and binds to the first extracellular loop of the histamine receptor [4], it was logical to search for an Asc binding site on the AR that could act allosterically to modify receptor sensitivity.
histamine receptor Binding (binds) of associated with dopamine
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0.36 Pain Relevance 0.20
RESULTS: Lidocaine (10-9-10-1 M) had no significant effects on agonist or antagonist binding to the hA1R or on receptor-G protein interactions.
hA1R Binding (binding) of
15) Confidence 0.00 Published 2003 Journal Anesthesiology Section Body Doc Link 14576545 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox