INT40647

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.24
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ggh) extracellular space (Ggh) extracellular region (Ggh)
lysosome (Ggh)
Anatomy Link Frequency
plasma 1
blood 1
muscles 1
Ggh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 5 99.72 Very High Very High Very High
Analgesic 16 99.42 Very High Very High Very High
Raphe 3 99.32 Very High Very High Very High
Opioid 1 99.18 Very High Very High Very High
Morphine 4 97.52 Very High Very High Very High
Raphe magnus 3 86.00 High High
anesthesia 2 77.24 Quite High
Enkephalin 2 75.00 Quite High
tolerance 4 73.92 Quite High
Potency 4 60.96 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 2 88.08 High High
Apnoea 1 69.24 Quite High
Leukemia 1 18.68 Low Low
Aging 22 5.00 Very Low Very Low Very Low
Toxicity 7 5.00 Very Low Very Low Very Low
Stress 7 5.00 Very Low Very Low Very Low
Drug-induced Liver Injury 7 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Repression 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest a differential distribution of inhibitory and excitatory drives of DIA and GH muscles within distinct raphe nuclei.
Gene_expression (muscles) of GH in muscles associated with raphe
1) Confidence 0.59 Published 2009 Journal Respir Physiol Neurobiol Section Abstract Doc Link 19135182 Disease Relevance 0.24 Pain Relevance 0.32
These results suggest that the opioids play a modulating role, stimulating the synthesis and secretion of GH, which affects the ultrastructural features of the hypophyseal GH cells.
Gene_expression (synthesis) of GH associated with opioid
2) Confidence 0.56 Published 1993 Journal J. Submicrosc. Cytol. Pathol. Section Abstract Doc Link 8462066 Disease Relevance 0 Pain Relevance 0.32
These temporal differences in plasma GH levels influence the activity of transcription factors Stat5b (signal transducer and activator of transcription 5b), Hnf4?
Gene_expression (levels) of GH in plasma
3) Confidence 0.13 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
Effects of naloxone on the basal levels of prolactin, LH or GH were inverse to the effects seen with narcotics and endorphins, therefore endorphins may play a role in regulating the basal levels of these hormones.
Gene_expression (levels) of GH associated with narcan
4) Confidence 0.08 Published 1980 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6110621 Disease Relevance 0 Pain Relevance 0.89
Acute administration of narcotic analgesics to rats increases the blood levels of ACTH, GH and prolactin, and decreases levels of LH and TSH, however, there is no general consensus regarding changes in serum FSH, ADH and oxytocin as induced by narcotics in rats.
Gene_expression (levels) of GH in blood associated with analgesic
5) Confidence 0.08 Published 1980 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6110621 Disease Relevance 0 Pain Relevance 0.51

General Comments

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