INT40660

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Context Info
Confidence 0.27
First Reported 1981
Last Reported 1981
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn, Prl) plasma membrane (Pdyn)
Pdyn (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 45 100.00 Very High Very High Very High
narcan 20 99.60 Very High Very High Very High
antagonist 5 99.58 Very High Very High Very High
opiate 5 99.36 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of dynorphin and beta h-endorphin (beta h-EP) to stimulate prolactin (PRL) release in male rats was examined.
dynorphin Positive_regulation (stimulate) of Localization (release) of prolactin associated with dynorphin
1) Confidence 0.27 Published 1981 Journal Endocrinology Section Abstract Doc Link 6111448 Disease Relevance 0 Pain Relevance 0.48
NAL, a specific opiate antagonist, completely blocked dynorphin-induced PRL release.
dynorphin Positive_regulation (induced) of Localization (release) of PRL associated with dynorphin, antagonist, narcan and opiate
2) Confidence 0.20 Published 1981 Journal Endocrinology Section Abstract Doc Link 6111448 Disease Relevance 0 Pain Relevance 0.71
The ability of dynorphin and beta h-endorphin (beta h-EP) to stimulate prolactin (PRL) release in male rats was examined.
dynorphin Positive_regulation (stimulate) of Localization (release) of PRL associated with dynorphin
3) Confidence 0.20 Published 1981 Journal Endocrinology Section Abstract Doc Link 6111448 Disease Relevance 0 Pain Relevance 0.48
Dynorphin caused a dose-dependent release of PRL which was significant 10 min after injection but not at later sampling times. beta h-EP also increased serum PRL levels and maintained elevated PRL levels for at least 60 min.
Dynorphin Positive_regulation (caused) of Localization (release) of PRL associated with dynorphin
4) Confidence 0.18 Published 1981 Journal Endocrinology Section Abstract Doc Link 6111448 Disease Relevance 0 Pain Relevance 0.67
Furthermore, dynorphin's action is specific since NAL completely blocked dynorphin induced PRL release.
dynorphin Positive_regulation (induced) of Localization (release) of PRL associated with dynorphin and narcan
5) Confidence 0.18 Published 1981 Journal Endocrinology Section Abstract Doc Link 6111448 Disease Relevance 0 Pain Relevance 0.67

General Comments

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