INT4067

Context Info Confidence 0.50 First Reported 1976 Last Reported 2011 Negated 2 Speculated 4 Reported most in Body Documents 97 Total Number 100 Disease Relevance 43.45 Pain Relevance 17.52

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1) cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)

Anatomy Link Frequency CPA 3 spinal 2 bridge 2 lumen 2 pseudotumor 1 Esr1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 380 100.00 Inflammatory marker 63 100.00 antagonist 151 99.96 anesthesia 72 99.92 Cannabinoid 10 99.92 Infliximab 403 99.82 abatacept 285 99.72 Serotonin 435 99.68 backache 7 99.40 Potency 33 99.36

Disease Link Frequency Relevance Heat INFLAMMATION 448 100.00 Cancer 813 99.96 Demyelinating Disease 9 99.92 Breast Cancer 232 99.84 Hypersensitivity 163 99.80 Anaerobic Bacterial Infections 31 99.80 Hypoxia 646 99.70 Diabetes Mellitus 89 99.52 Insulin Resistance 90 99.44 Disease 459 99.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When membranes are prepared in the presence of a water-soluble spin label, TEMPOcholine, ascorbate destroys the signal of untrapped label; when mixed phospholipid-tetracaine are formed by addition of micellar tetracaine, this leads to a complete loss of the ESR signal.

Negative_regulation (loss) of ESR

1) Confidence 0.50 Published 1986 Journal Biochim. Biophys. Acta Section Abstract Doc Link 3017421 Disease Relevance 0 Pain Relevance 0.17

In a portion of human tumors, decreased ER levels in tumors after tamoxifen treatment has been shown to predict tamoxifen resistance [25].

Negative_regulation (decreased) of ER associated with cancer

2) Confidence 0.48 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.19 Pain Relevance 0

The biological effects of raloxifene decrease the ER levels [8,31].

Negative_regulation (decrease) of ER

3) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.50 Pain Relevance 0

In the Tg(PyV-mT) model, relatively high numbers of ER-positive cells are found in the early MIN stage, but invasive tumorigenesis is associated with loss of ER [5].

Negative_regulation (loss) of ER associated with cancer

4) Confidence 0.42 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.72 Pain Relevance 0

Moreover, ER-receptor blockade using the ER antagonist ICI 182,780 triggered an earlier onset and increased severity of CIA [10].

Negative_regulation (blockade) of ER associated with antagonist and arthritis

5) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.53 Pain Relevance 0.55

-mediated inhibition of ER?

Negative_regulation (inhibition) of ER

6) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.68 Pain Relevance 0.19

expression in the Leydig cells and elongating spermatids of adult mice [24], others reporting a developmental decline in ER?

Negative_regulation (decline) of ER in spermatids

7) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0

CONCLUSION: Across all patients with AS, SSZ showed some benefit in reducing ESR and easing spinal stiffness, but no evidence of benefit in physical function, pain, spinal mobility, enthesitis, or patient and physician global assessment.

Negative_regulation (reducing) of ESR in spinal

8) Confidence 0.37 Published 2006 Journal J. Rheumatol. Section Body Doc Link 16583475 Disease Relevance 0 Pain Relevance 0

ESR was decreased on the opposite tender points of the abdominal walls as compared with those values of the healthy abdominal walls.

Negative_regulation (decreased) of ESR

9) Confidence 0.37 Published 1976 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 964022 Disease Relevance 0.76 Pain Relevance 0.67

ESR was decreased on the abdominal walls where visceral pain was induced by inflation of a balloon attached to the apex of a Miller-Abbott double lumen tube.

Negative_regulation (decreased) of ESR in lumen associated with visceral pain

10) Confidence 0.37 Published 1976 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 964022 Disease Relevance 0.77 Pain Relevance 0.69

Interestingly, after treatment with ERA-63, a more profound increase in uterus weight was observed in ER?

Negative_regulation (observed) of ER in uterus

11) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.54 Pain Relevance 0.12

-agonist ERA-63 decreased the DTH response in both wild type and ER?

Negative_regulation (decreased) of ERA-63 associated with hypersensitivity and agonist

12) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.88 Pain Relevance 0.18

ERA-63 inhibits the tetanus toxoid (TT)-specific DTH response in WT and ER?

Negative_regulation (inhibits) of ERA-63 associated with hypersensitivity and anaerobic bacterial infections

13) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.66 Pain Relevance 0.22

Differential effects of ER?

Negative_regulation (effects) of ER

14) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.35 Pain Relevance 0.36

While myelin and axons are preserved in the CNS, it cannot be discerned whether the effect of ER?

Spec (whether) Negative_regulation (effect) of ER associated with central nervous system

15) Confidence 0.35 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.23 Pain Relevance 0.60

HB carried out the tissue processing and stereological analyses on the seminiferous tubules, MOW carried out the in vivo studies and the Western Blot and ER immunohistochemistry, GRH and RAW carried out the immunostaining for 3?

Negative_regulation (immunohistochemistry) of ER in seminiferous tubules

16) Confidence 0.33 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0

Blockade of ER?

Negative_regulation (Blockade) of ER

17) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.14 Pain Relevance 0.03

Mice that lack ER?

Negative_regulation (lack) of ER

18) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.18 Pain Relevance 0.05

The purpose of the present study was to: (1) investigate whether Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and its analogs [Delta(8)-tetrahydrocannabinol (Delta(8)-THC), HU-210, CP 55,940, and WIN 55,212-2] can prevent the DOI-induced behaviors and (2) to see whether any correlation exists in the ID(50) potency order of these cannabinoids in inhibiting the DOI-induced HTR and ESR relative to their published ED(50) potency profiles in producing the tetrad of behaviors in mice.

Negative_regulation (inhibiting) of ESR associated with cannabinoid and potency

19) Confidence 0.32 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11267636 Disease Relevance 0 Pain Relevance 0.41

In our study, the E2 effect was mimicked by PPT, a highly selective agonist of ER?

Negative_regulation (agonist) of ER associated with agonist

20) Confidence 0.31 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.13

General Comments

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