INT40698

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Context Info
Confidence 0.32
First Reported 1980
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.84
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Aes)
Anatomy Link Frequency
brains 1
Aes (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 1 99.04 Very High Very High Very High
cva 34 87.52 High High
Enkephalin 1 82.48 Quite High
Acupuncture 2 75.00 Quite High
drug abuse 1 75.00 Quite High
Potency 7 68.84 Quite High
Inflammation 48 57.48 Quite High
Inflammatory response 2 16.84 Low Low
anesthesia 2 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Toxicity (including Many Sub-types) 96 100.00 Very High Very High Very High
Myeloid Leukemia 38 100.00 Very High Very High Very High
Ocular Hypertension 24 100.00 Very High Very High Very High
Thrombocytopenia 4 100.00 Very High Very High Very High
Neutropenia 1 100.00 Very High Very High Very High
Cataract 14 97.60 Very High Very High Very High
Disease Progression 8 92.24 High High
Retinal Perforations 12 91.92 High High
Death 4 87.72 High High
Cv General 3 Under Development 8 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fraction I of the opiate activity in the brains of mice was found to be increased after AES.
Positive_regulation (increased) of AES in brains associated with opiate
1) Confidence 0.32 Published 1980 Journal Am. J. Chin. Med. Section Abstract Doc Link 6113757 Disease Relevance 0.07 Pain Relevance 0.29
Vascular AEs
Positive_regulation (Vascular) of AEs associated with ocular toxicity (including many sub-types)
2) Confidence 0.21 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 1.33 Pain Relevance 0.04
In FOCUS, transient increased IOP AEs were reported in 16.2% of the ranibizumab plus PDT group versus 1.8% in the PDT-alone group (P=0.007) (Heier et al. 2006b).
Positive_regulation (increased) of AEs associated with ocular toxicity (including many sub-types) and ocular hypertension
3) Confidence 0.20 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 1.76 Pain Relevance 0.28
The most frequent grade 3/4 AEs in patients with CP CML were neutropenia (29%), thrombocytopenia (29%), asymptomatic serum lipase elevation (14%) and bilirubin elevation (9%) [42].
Positive_regulation (elevation) of AEs associated with neutropenia, myeloid leukemia and thrombocytopenia
4) Confidence 0.18 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2567340 Disease Relevance 0.68 Pain Relevance 0.03

General Comments

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